100% Original Cas No.26575-93-9 - Nochlorogenic acid；5-Caffeoylquinicacid – Yongjian
100% Original Cas No.26575-93-9 - Nochlorogenic acid；5-Caffeoylquinicacid – Yongjian Detail:
Application of Neochlorogenic Acid
Neochlorogenic acid is a natural polyphenol compound found in dried fruits and other plants. Neochlorogenic acid inhibits TNF- α And IL-1 β Produce. Neochlorogenic acid inhibited the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibits phosphorylated NF- κ B p65 and p38 MAPK activation.
Biological Activity of Neochlorogenic Acid
Description: eochlorogenic acid is a natural polyphenol compound found in dried fruits and other plants. Neochlorogenic acid inhibits TNF- α And IL-1 β Produce. Neochlorogenic acid inhibited the expression of iNOS and COX-2 proteins. Neochlorogenic acid also inhibits phosphorylated NF- κ B p65 and p38 MAPK activation.
Related Categories: signal pathway > > immunity and inflammation
> > interleukin related
signaling pathway > > apoptosis > > TNF receptor
natural Products > > benzoic acids
Research Field > > inflammation / immunity
Target:p65
IL-1β
TNF-α
COX-2
In Vitro Studies: neochlorogenic acid (NCA) inhibits the expression of iNOS and COX-2 proteins and proinflammatory cytokines (such as TNF) in BV2 microglia- α And IL-1 β） The production showed that lipopolysaccharide (LPS) – induced no production decreased. In addition, phosphorylated p38 MAPK and NF- κ Bp65 was also inhibited by neochloric acid in activated microglia. LPS induced elevated iNOS and COX-2 levels in BV2 cells, but with 50 and 100 μ This increase was significantly inhibited after m-hypochlorous acid treatment [1].
Cell Experiment: mouse BV2 microglia were maintained in DMEM, supplemented with 5% FBS and 1% antibiotic antifungal agent at 37 ℃ in a humid incubator containing 5% CO 2. Neochlorogenic acid and dexamethasone as positive controls were dissolved in DMSO until the final concentration of the stock solution was 10 mm. Treatment with LPS and / or neochlorogenic acid was performed under serum-free conditions. The effect of neochlorogenic acid on cell viability of BV2 microglia stimulated by lipopolysaccharide (LPS) was measured. With or without LPS (4) μ G / ml) and neochlorogenic acid (10, 50 and 100 μ M) Cells were treated for 24 hours. Dexamethasone (10) μ M) For positive control. Cell viability was confirmed by MTT assay. Remove the medium from the well, add MTT, and then incubate the sample at 37 ℃ for 3 hours. Methyl crystals were dissolved by adding DMSO, and the absorbance value was measured at 540 nm using an enzyme labeling instrument [1].
References: [1] Kim M, et al. Neochlorogenic Acid Inhibits Lipopolysaccharide-Induced Activation and Pro-inflammatory Responses in BV2 Microglial Cells. Neurochem Res. 2015 Sep; 40(9):1792-8.
Physicochemical Properties Of Neochlorogenic Acid
Density: 1.7 ± 0.1 g / cm3
Boiling Point: 665.0 ± 55.0 ° C at 760 mmHg
Molecular Formula: C16H18O9
Molecular Weight: 354.309
Flash Point: 245.5 ± 25.0 ° C
Accurate Mass: 354.095093
PSA:164.75000
LogP:-0.36
Appearance: white powder
Steam Pressure: 0.0 ± 2.1 mmHg at 25 ° C
Refractive Index: 1.690
Storage Conditions: 2-8 ° C
Stability: it exists in flue-cured tobacco, burley tobacco and flue gas.
Molecular Structure
1.Molar refractive index: 82.03
2. Molar volume (cm3 / mol): 214.5
3. Isotonic specific volume (90.2k): 681.7
4. Surface tension (dyne / cm): 101.9
5.Polarizability (10-24cm3): 32.52
Neochlorogenic Acid Safety Information
Transport code of dangerous goods: nonh for all modes of transport
Customs Code: 29182900
Preparation Of Neochlorogenic Acid
1. Tobacco：FC，53；FC，BU，6
Neochlorogenic Acid Literature
Physicochemical characterisation of four cherry species (Prunus spp.) grown in China.
Food Chem. 173 , 855-63, (2014)
The physicochemical characteristics of four cherry species (Prunus avium, Prunus cerasus, Prunus pseudocerasus and Prunus tomentosa) were evaluated. Inter-species variability was greater than intra-sp…
Chemical profiling and quantification of Gua-Lou-Gui-Zhi decoction by high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and ultra-performance liquid chromatography/triple quadrupole mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 986-987 , 69-84, (2015)
Gua-Lou-Gui-Zhi decoction (GLGZD) is a classical formula of traditional Chinese medicine, which has been commonly used to treat dysfunction after stroke, epilepsy and spinal cord injury. In this study…
Optimization of extraction parameters on the isolation of phenolic compounds from sour cherry (Prunus cerasus L.) pomace.
J. Food Sci. Technol. 52(5) , 2851-9, (2015)
There is an increasing interest to bio-components obtained from fruit & vegetable wastes. Anthocyanin is one of the components regained from fruits especially from red ones. Sour cherry is considered …
English Alias of Neochlorogenic Acid
(1R,3R,4S,5R)-3-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,4,5-trihydroxycyclohexane-1-carboxylic acid
3-{[3-(3,4-Dihydroxyphenyl)acryloyl]oxy}-1,4,5-trihydroxycyclohexanecarboxylic acid
4-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2-propenyl]oxy] 1,4,5-trihydroxycyclohexanecarboxylic acid
Cyclohexanecarboxylic acid, 3-[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,4,5-trihydroxy-
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., established in March 2012, is a high-tech enterprise integrating R & D, production and sales. It is mainly engaged in the production, customization and production process development of active components of natural products, traditional Chinese medicine reference materials and drug impurities. The company is located in China Pharmaceutical City, Taizhou City, Jiangsu Province, including a 5000 square meter production base and a 2000 square meter R & D base. It mainly serves major scientific research institutes, universities and decoction piece production enterprises across the country.
So far, we have developed more than 1500 kinds of natural compound reagents, and compared and calibrated more than 300 kinds of reference materials, which can fully meet the daily inspection needs of major scientific research institutes, university laboratories and decoction pieces production enterprises.
Based on the principle of good faith, the company hopes to sincerely cooperate with our customers. Our aim is to serve the modernization of traditional Chinese medicine.
Advantageous Business Scope Of The company
1. R & D, production and sales of chemical reference materials of traditional Chinese medicine;
2. Customized traditional Chinese medicine monomer compounds according to customer characteristics
3. Research on quality standard and process development of traditional Chinese medicine (plant) extract
4. Technology cooperation, transfer and new drug research and development.
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Our eternal pursuits are the attitude of "regard the market, regard the custom, regard the science" as well as the theory of "quality the basic, believe in the 1st and management the advanced" for 100% Original Cas No.26575-93-9 - Nochlorogenic acid；5-Caffeoylquinicacid – Yongjian , The product will supply to all over the world, such as: Jakarta, Croatia, Armenia, Based on our automatic production line, steady material purchase channel and quick subcontract systems have been built in mainland China to meet customer's wider and higher requirement in recent years. We are looking forward to cooperating with more clients worldwide for common development and mutual benefit!Your trust and approval are the best reward for our efforts. Keeping honest, innovative and efficient, we sincerely expect that we can be business partners to create our brilliant future!
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