Cheap price Hydroxysafflor yellow A - Isoliquiritin Apioside – Yongjian
Cheap price Hydroxysafflor yellow A - Isoliquiritin Apioside – Yongjian Detail:
Application of Isoliquiritin Apioside
Isoliquiritin apioside, a component isolated from glycorrhizae radio rhome, significantly reduced PMA induced increase in MMP9 activity and inhibited PMA induced MAPK and NF- κ B activation. Isoliquitin apioside inhibits the invasion and angiogenesis of cancer cells and endothelial cells.
Name of Isoliquiritin Apioside
Chinese Name: Isoliquiritin Apioside
English Name: (E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Bioactivity of Isoliquiritin Apioside
Description: isoliquitin apioside, a component isolated from glycorrhizae radio rhome, significantly reduced PMA induced increase in MMP9 activity and inhibited PMA induced MAPK and NF- κ B activation. Isoliquitin apioside inhibits the invasion and angiogenesis of cancer cells and endothelial cells.
Related Categories: research field > > cancer
Signal path > > MAPK / ERK signal path > > p38 MAPK
Signaling pathway > > metabolic enzyme / protease > > MMP
Target: MMP9
NF-κB
p38 MAPK
In vitro study: isorlicin could effectively inhibit the gelation MMP-9 activity of PMA induced HT1080 cells. Isoglycyrrhizin apigenin reduces the increase of MMP-9 production in HT1080 cells induced by PMA, has the ability of anti metastasis and anti angiogenesis in malignant tumor cells and endothelial cells, and has no cytotoxicity [1].
Reference: [1]. Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455.
Physicochemical properties of Isoliquiritin Apioside
Density: 1.6 ± 0.1 g / cm3
Boiling point: 901.0 ± 65.0 ° C at 760 mmHg
Molecular formula: c26h30o13
Molecular weight: 550.509
Flash point: 301.9 ± 27.8 ° C
Accurate mass: 550.168640
PSA:215.83000
LogP:1.96
Steam pressure: 0.0 ± 0.3 mmHg at 25 ° C
Refractive index: 1.709
English alias of Isoliquiritin Apioside
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
Product detail pictures:
Related Product Guide:
We usually continually offer you the most conscientious consumer services, along with the widest variety of designs and styles with finest materials. These initiatives include the availability of customized designs with speed and dispatch for Cheap price Hydroxysafflor yellow A - Isoliquiritin Apioside – Yongjian , The product will supply to all over the world, such as: Denver, Palestine, Slovak Republic, We strongly believe that technology and service is our base today and quality will create our reliable walls of future. Only we've got better and better quality , could we achieve our customers and ourselves, too. Welcome customers all over the word to contact us for getting further business and reliable relationships. We have been always here working for your demands whenever you require.
By John biddlestone from Borussia Dortmund - 2017.05.31 13:26
The company can keep up with the changes in this industry market, product updates fast and the price is cheap, this is our second cooperation, it's good.
By Matthew Tobias from Oman - 2017.09.26 12:12