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China Manufacturer for Kirenol - Dimethylfraxetin ;6,7,8-Trimethoxycoumarin – Yongjian

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China Manufacturer for Kirenol - Dimethylfraxetin ;6,7,8-Trimethoxycoumarin – Yongjian Detail:

Product Specification

Common Name: ash tree element
CAS No.: 6035-49-0
Density: 1.2 ± 0.1 g / cm3
Molecular Formula: C12H12O5
MSDS: N / A

English Name: dimethylfraxetin
Molecular Weight: 236.221
Boiling Point: 408.0 ± 45.0 ° C at 760 mmHg
Melting Point: 104-105 º C
Flash Point: 184.3 ± 28.8 ° C

Biological activity of dimethylfraxetin

Description: dimethylfraxetin is a carbonic anhydrase inhibitor with a Ki value of 0.0097 μ M。

Related Categories:
signal pathway > > metabolic enzyme / protease > > carbonic anhydrase

Research field > > cancer

Natural Products > > benzoic acids

Target: ki: 0.0097 μ M (Carbonic anhydrase)[1]

In vitro study: in CA I, one prominent compound is dimethylfluoxetine (compound 17), a nanomolar CA I inhibitor. This trimethoxycoumarin is the most effective of any NP coumarin among the six CA isozymes in this study [1].
Kinase: before determination, the inhibitor (including dimethylerythromycin) and the enzyme solution were pre incubated at room temperature for 6 hours to allow the formation of enzyme inhibitor complex [1]

References: [1]  Davis RA, et al. Natural product coumarins that inhibit human carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15; 21(6):1539-43.

Dimethylfraxetin

Density: 1.2 ± 0.1 g / cm3
Boiling Point: 408.0 ± 45.0 ° C at 760 mmHg
Melting Point: 104-105 º C
Molecular Formula: c12h12o5
Molecular Weight: 236.221
Flash Point: 184.3 ± 28.8 ° C
Accurate Mass: 236.068466
PSA:57.90000
LogP:1.75
Steam Pressure: 0.0 ± 1.0 mmHg at 25 ° C
Refractive index: 1.545

Dimethylfraxetin Safety Information

Risk statement (Europe): 22
Safety statement (Europe): 22-45
Customs Code: 293220990

Dimethylfraxetin Upstream And Downstream Products

DDimethylfraxetin Upstream Products

CAS 186581-53-3 Diazomethane
CAS No. 486-21-5 Isozinpidine
CAS 107078-01-3 6-hydroxy-7,8-d…
CAS No. 77-78-1 Dimethyl sulfate
DDimethylfraxetin Downstream Products
CAS No.72023-44-0 2,3,4,5-tetrame…

Dimethylfraxetin Customs

Customs Code: 293220990
Chinese overview: 293220990 Other lactones VAT rate: 17.0% Tax rebate rate: 13.0% Regulatory conditions: none MFN tariff: 6.5% General tariff: 20.0%
Declaration elements: product name, composition, content and purpose
Summary:2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

English Alias Of Dimethylfraxetin

6,7,8-trimethoxychromen-2-one
6,7,8-Trimethoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one, 6,7,8-trimethoxy-


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China Manufacturer for Kirenol - Dimethylfraxetin ;6,7,8-Trimethoxycoumarin –  Yongjian detail pictures


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  • The company leader recept us warmly, through a meticulous and thorough discussion, we signed a purchase order. Hope to cooperate smoothly
    5 Stars By Quintina from Sweden - 2017.09.26 12:12
    The customer service staff's answer is very meticulous, the most important is that the product quality is very good, and packaged carefully, shipped quickly!
    5 Stars By Gary from Somalia - 2018.02.12 14:52
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