Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Enw
Enw Saesneg:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-manopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Bioactifedd Ophiopogon Japonicus Saponin D
Disgrifiad:Mae Ophiopogon D yn glycosid steroidal C29 naturiol prin wedi'i ynysu o gloronen Ophiopogon japonicus.Mae Ophiopogonin D yn inducer CYP2J3 sy'n cynyddu CYP2J2 / eets a PPAR mewn celloedd endothelaidd gwythiennau umbilical dynol (HUVECs) α Mae mynegiant Ang II yn atal yn sylweddol Ang II ysgogwyd NF- κ B trawsleoli niwclear, I κ B α rheoliad Down, mewngellol Ca2 + gorlwytho ac actifadu cytocinau prolidiol.Mae Ophiopogonin D wedi cael ei ddefnyddio i drin llid a chlefydau cardiofasgwlaidd ers miloedd o flynyddoedd.
Categorïau Perthnasol
Llwybr signalau > > cludo trawsbilen > > sianel galsiwm
Maes ymchwil > > clefyd cardiofasgwlaidd
Llwybr signalau > > cylchred gell / difrod DNA > > PPAR
Maes ymchwil > > llid / imiwnedd
Targed
PPARα
NF-κB
Ca2+
Dogfennau Cyfeirio:[1].Wang L , et al.Homo-aro-cholestane, furostane a saponins spirostane o gloron Ophiopogonjaponicus.Ffytocemeg.2017 Ebrill; 136:125-132.
[2].Mae Huang X, et al.Mae Ophiopogonin D ac EETs yn lleddfu ymatebion llidiol a achosir gan Ang II trwy actifadu PPARα mewn HUVECs.Biochem Biophys Res Commun.2017 Awst 19; 490(2): 123-133.
Alias Saesneg Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-manopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Offiopogonin D
Deacetylophiopogonin C
