Esculetin; Aesculetin；Asculetine; Cichorigenin; Esculetol
Application of Esculetin
[purpose I]
Used as pharmaceutical intermediate
Name Of Esculetin
Chinese Name: 6,7-dihydroxycoumarin
English Name: esculetin
Chinesea Alias: Aesculetin, Aesculetin, Aesculetin B, Aesculetin a; Aescin; Horse millet bark glycoside; Aesculin, chestnut bark, Aesculetin B, 6,7-dihydroxylavender
Bioactivity Of Esculetin
Description: esculetin is an active ingredient mainly extracted from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF) - induced phenotypic transformation of airway smooth muscle cells (ASMCs) by inhibiting PI3K / Akt pathway. Esculetin has antioxidant, anti-inflammatory and anti-tumor effects.
Related categories: research field > > cancer
Signal pathway > > PI3K / Akt / mTOR signal pathway > > PI3K
Signal pathway > > PI3K / Akt / mTOR signal pathway > > Akt
Target: PI3K Akt
References: [1] Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytother Res. 2019 Aug 21.
Physicochemical Properties of Esculetin
Density: 1.6 ± 0.1 g / cm3
Boiling Point: 469.7 ± 45.0 ° C at 760 mmHg
Melting Point: 271-273 ° C (lit.)
Molecular Formula: c9h6o4
Molecular Weight: 178.141
Flash Point: flash point
Accurate Mass: 178.026611
PSA:70.67000
LogP:0.98
Appearance: yellow crystalline powder
Steam Pressure: 0.0 ± 1.2 mmHg at 25 ° C
Refractive Index: 1.689
Storage Conditions: 2-8 ° C
Stability
1 It exists in flue-cured tobacco and Burley tobacco.
2. It is used in the color filter to absorb ultraviolet light.
Water solubility: slightly soluble
Molecular Structure
1. Molar refractive index: 43.52
2. Molar volume (cm3 / mol): 113.9
3. Isotonic specific volume (90.2k): 336.0
4. Surface tension (dyne / cm): 75.6
5. Polarizability (10-24cm3): 17.25
Toxicological Data Of Esculetin
Toxicological data:
Acute toxicity: not available.
Aesculetin ecological data:
Ecological data:
Other harmful effects: the substance may be harmful to the environment, so special attention should be paid to the water body.
Esculetin Safety Information
Hazard statement: h315-h319-h335
Warning Statement: p261-p305 + P351 + P338
Personal Protective Equipment: dust mask type N95 (US); Eyeshields; Gloves
Hazard Code (Europe): Xi: iritant
Risk Statement (Europe): R36 / 37 / 38
Safety Statement (Europe): s26-s36-s37 / 39
Transport Code Of Dangerous Goods: nonh for all modes of transport
Wgk Germany: 3
RTECS No.: gn6382500
Packing Grade: I; II; III
Customs Code: 293220990
Preparation Of Esculetin
1.It is obtained by acylation and cyclization of benzoquinone.
2.Obtained by hydrolysis of aescin or cichorin.
Esculetin Customs
Customs Code: 293220990
Chinese overview: 293220990 Other lactones VAT rate: 17.0% Tax rebate rate: 13.0% Regulatory conditions: none MFN tariff: 6.5% General tariff: 20.0%]
Declaration Elements: product name, composition, content and purpose
Summary:2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Esculetin Literature
Coumarins as new matrices for matrix-assisted laser-desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of hydrophobic compounds.
Anal. Chim. Acta 882 , 49-57, (2015)
Hydrophobic compounds with hydroxyl, aldehyde or ketone groups are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), because these compounds...
The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor.
J. Insect Physiol. 57(4) , 501-7, (2011)
Eicosanoids are oxygenated metabolites of three C20 polyunsaturated fatty acids, mainly arachidonic acid (AA; 20:4n-6), but also 20:3n-6 and 20:5n-3. Aside from their importance in biomedicine, eicosa...
Zinc oxide nanoparticles induce lipoxygenase-mediated apoptosis and necrosis in human neuroblastoma SH-SY5Y cells.
Neurochem. Int. 90 , 204-14, (2015)
Zinc oxide nanoparticles (ZnO NPs) are known to induce oxidative stress and modulate an inflammatory process in various cell types. Although the cytotoxic effects of ZnO NPs in various cell types have...
English Alias Of Esculetin
Aesculetin
Cryptotanshinone
ESCULETOL
CICHERINGENIN
Cichorigenin
Asculetine
Esculatin
6,7-Dihydroxycoumarin
Esculetin
2H-1-Benzopyran-2-one, 6,7-dihydroxy-
6,7-dihydroxy-2H-1-benzopyran-2-one
Coumarin, 6,7-dihydroxy-
MFCD00006874
EINECS 206-161-5
