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Biological Activity of Panaxadiol

Description: Panaxadiol is a novel antitumor drug isolated from ginseng.

Related categories: signal path > > other > > other

Research field > > cancer

Natural Products > > terpenoids and glycosides

Reference: [1]. Xiaojun C, et al. An UFLC-MS/MS method for quantification of panaxadiol in rat plasma and its application to a pharmacokinetic study. Planta Med. 2013 Sep;79(14):1324-8.

[2]. Tae-Hoon Kim, et al. The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart. Food and Chemical ToxicologyVolume 48, Issue 6, June 2010, Pages 1516–1520

Physicochemical Properties Of Panaxadiol

Density: 1.0 ± 0.1 g / cm3

Boiling Point: 531.3 ± 45.0 ° C at 760 mm

HgMolecular Formula: C30H52O3

Molecular Weight: 460.732

Flash Point: 275.1 ± 28.7 ° C

Accurate Mass: 460.391632

PSA: 49.69000

LogP: 7.64

Vapor Pressure: 0.0 ± 3.2 mmHg at 25 ° C

Refractive Index: 1.515

1. Character: uncertain

2. Density (g / ml, 25 / 4 ℃): uncertain

3. Relative vapor density (g / ml, air = 1): uncertain

4. Melting point (º C): 250

5. Boiling point (º C, atmospheric pressure): uncertain

6. Boiling point (º C, 5.2kpa): uncertain

7. Refractive index: uncertain

8. Flash point (º C): uncertain

9. Specific rotation (º): uncertain

10. Spontaneous combustion point or ignition temperature (º C): uncertain

11. Vapor pressure (kPa, 25 º C): uncertain

12. Saturated vapor pressure (kPa, 60 º C): uncertain

13. Heat of combustion (kJ / mol): uncertain

14. Critical temperature (º C): uncertain

15. Critical pressure (kPa): uncertain

16. Logarithm of oil-water (octanol / water) partition coefficient: uncertain

17. Upper explosion limit (%, V / V): uncertain

18. Lower explosive limit (%, V / V): uncertain

19. Solubility: uncertain

Preparation of Panaxadiol

The latest preparation method of ginseng extract is as follows: 100g of 5 ~ 6-year-old people are crushed and stirred into mud, 400ml of 90% ethanol is added, soaked and stirred for one day and night, filtered, and 300ml of 90% ethanol is added to the filter residue for the second extraction. Combine the two filtrates and evaporate the ethanol in the evaporator, leaving about 4G of concentrate. Add 150ml of 60% in the concentrate, stir to dissolve, filter and remove the insoluble matter. Concentrate the filtrate to 5-10ml, add 60ml of water, extract it with 80ml of ether for 3 times in the separating funnel, combine the ether layer, add 50ml of 6% sodium bicarbonate solution, shake fully, stand for layering, take the ether layer and wash it with distilled water to neutral. Then the ether is removed by evaporator until the ether is completely distilled, and the obtained ginseng extract.

English Alias Of Panaxadiol

PALMITIC ACID METHYLESTER(RG) (SEE METHYL PALMITATE)

(3β,12β,20R)-20,25-Epoxydammarane-3,12-diol

Panaxaidol

DAMMARANE-3BETA,12BETA-DIOL

Dammarane-3,12-diol, 20,25-epoxy-, (3β,12β,20R)-

Panaxadio