Factory wholesale Eriocalyxin B - Glabridin – Yongjian
Factory wholesale Eriocalyxin B - Glabridin – Yongjian Detail:
Application of Glabridin
Glucoridin is an isoflavane from glycorrhiza glabra, which can bind and activate PPAR γ， The EC50 value is 6115 nm. Glabridin has antioxidant, antibacterial, anti glomerulonephritis, anti diabetes, anti-tumor, anti-inflammatory, anti osteoporosis, protect cardiovascular, protect the nerves, scavenge free radicals and other functions.
Bioactivity of Glabridin
Description: glucoridin is an isoflavane from glycorrhiza glabra, which can bind and activate PPAR γ， The EC50 value is 6115 nm. Glabridin has antioxidant, antibacterial, anti glomerulonephritis, anti diabetes, anti-tumor, anti-inflammatory, anti osteoporosis, protect cardiovascular, protect the nerves, scavenge free radicals and other functions.
Related Categories: research field > > cancer
Signaling pathway > > cell cycle / DNA damage > > PPAR
Research field > > inflammation / immunity
In Vitro Study: glabridin binds and activates PPAR γ， EC50 is 6115 nm [1]. Glabridin（40,80 μ M) The proliferation of SCC-9 and SAS cell lines was inhibited in a dose and time-dependent manner after 24 and 48 hours of treatment [2]. Glabridin（0-80 μ M) It also induces apoptosis, leading to sub G1 cell cycle arrest in SCC-9 and SAS cell lines [2]. Glabridin (0,20,40 and 80 μ M) Dose dependently activated Caspase-3, – 8 and – 9 and increased PARP cleavage, significantly phosphorylating ERK1 / 2, JNK1 / 2 and P-38 MAPK in SCC-9. Cells [2].
In Vivo Study: glabridin (50 mg / kg, Po once daily) showed strong anti-inflammatory activity and improved the inflammatory changes induced by dextran sodium sulfate (DSS) [3]
References: [1] Rebhun JF, et al. Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPAR γ). Fitoterapia. 2015 Oct; 106:55-61.
[2]. Chen CT, et al. Glabridin induces apoptosis and cell cycle arrest in oral cancer cells through the JNK1/2 signaling pathway. Environ Toxicol. 2018 Jun; 33(6):679-685.
[3]. El-Ashmawy NE, et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr; 26(2):551-559.
Physicochemical Properties Of Glabridin
Density: 1.3 ± 0.1 g / cm3
Boiling Point: 518.6 ± 50.0 ° C at 760 mmHg
Melting Point: 154-155 º C
Molecular Formula: c20h20o4
Molecular Weight: 324.37
Flash Point: 267.4 ± 30.1 ° C
Exact Mass: 324.136169
PSA:58.92000
LogP:4.26
Appearance: Light yellow powder
Refractive Index: 1.623
Storage Condition: room temp
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