Fraxetin; Fraxetol; 7,8-Dihydroxy-6-methoxycoumarin CAS No: 574-84-5
Summary
Alias: Qinpi Pavilion; Fraxinus lactone
English Name: fraxetin;fraxetol
It belongs to coumarin compounds. It is flake crystal (ethanol), melting point 228 ℃, turns yellow at 150 ℃, and turns brown at melting point. It is the hydrolysate of aesculin, soluble in ethanol and hydrochloric acid aqueous solution, slightly soluble in boiling water and insoluble in ether.
It comes from Fraxinus brngeana DC Bark, leaves of F. floribunda wall, etc.
It has the effect of anti dysentery bacilli and is clinically used to treat acute bacillary dysentery in children.
Products supply fraxetin: Qinpi Pavilion
Product parameters: CAS No: 574-84-5
Effective content (%): 98.5%
Application: content determination, pharmacological reagent, etc
Product specification: 10mg, 20mg, 1g
Supply fraxetin: Qinpiting, also known asFraxinus lactone
English Name: fraxetin; Fraxetol； Fraxexin； Coumarin, 7,8-dihydroxy-6-methoxy-
CAS No: 574-84-5
Pure natural extraction, after NMR structure confirmation and HPLC purity detection, the content is more than 98.5%.
Chinese alias: 7,8-dihydroxy-6-methoxycoumarin English Name: 7,8-dihydroxy-6-methoxycoumarin English alias: EINECS No.: 209-376-2 molecular formula: c10h8o5 molecular weight: 208.1675inchi: Inchi = 1 / c10h8o5 / c1-14-6-4-5-2-3-7 (11) 15-10 (5) 9 (13) 8 (6) 12 / h2-4,12-13h, 1h3 density: 1.508g/cm boiling point: 472 ° C at 760 mmHg flash point: 196 ° C
Physicochemical Properties Of Fraxetin
Density: 1.5 ± 0.1 g / cm3
Boiling Point: 472.0 ± 45.0 ° C at 760 mmHg
Melting Point: 230-232 ° C
Molecular Formula: c10h8o5
Molecular Weight: 208.167
Flash Point: 196.0 ± 22.2 ° C
Accurate Mass: 208.037170
PSA:79.90000
LogP:0.59
Appearance: light yellow crystal tablet
Stability: pale yellow flake crystal, the color becomes darker when heated, and becomes Brown near the melting point. Slightly soluble in ether and boiling waterThe light yellow flake crystal turns dark when heated, and turns brown near the melting point. Slightly soluble in ether and boiling water,It appears blue-green in the presence of ferric chloride. Stable under normal temperature and pressure.
Computational Chemistry
1. Reference value for hydrophobic parameter calculation (xlogp): 1.2
2. Number of hydrogen bond donors: 2
3. Number of hydrogen bond receptors: 5
4. Number of rotatable chemical bonds: 1
5. Number of tautomers: 16
6. Topological molecular polarity surface area 76
7. Number of heavy atoms: 15
8. Surface charge: 0
9. Complexity: 288
10. Number of isotopic atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Number of uncertain atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of indeterminate chemical bond stereocenters: 0
15. Number of covalent bond units: 1
