Ophiopogonin D Cas No.945619-74-9
Ainm Ophiopogon Saponin D
Ainm Beurla:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-manopyranosyl-(1-> 2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Bith-ghnìomhachd Ophiopogon Japonicus Saponin D
Tuairisgeul:Tha Ophiopogon D na glycoside steroidal C29 nàdarra tearc air a sgaradh bho thubair Ophiopogon japonicus.Tha Ophiopogonin D na inducer CYP2J3 a tha ag àrdachadh CYP2J2 / eets agus PPAR ann an ceallan endothelial vein umbilical daonna (HUVECs) α Chuir abairt Ang II bacadh mòr air gluasad niùclasach NF- κ B air a bhrosnachadh le Ang II, riaghladh I κ B α Down, Ca2 + intracellular cus luchd agus gnìomhachadh cytokines proinflammatory.Chaidh Ophiopogonin D a chleachdadh airson sèid agus galairean cardiovascular airson mìltean de bhliadhnaichean.
Roinnean-seòrsa iomchaidh
Slighe comharran >> còmhdhail transmembrane >> sianal calcium
Raon rannsachaidh > > galar cardiovascular
Slighe comharran >> cearcall cealla / milleadh DNA >> PPAR
Raon rannsachaidh >> sèid / dìonachd
Targaid
PPARα
NF- κB
Ca2+
Sgrìobhainnean iomraidh:[1].Wang L , et al.Homo-aro-cholestane, furostane agus saponins spirostane bho na tubers de Ophiopogonjaponicus.Phytochemistry.2017 Giblean; 136: 125-132.
[2].Huang X, et al.Bidh Ophiopogonin D agus EETs a’ lughdachadh freagairtean sèidteach Ang II tro bhith a’ cur an gnìomh PPARα ann an HUVECn.Biochem Biophys Res Commun.2017 Lùnastal 19; 490(2): 123-133.
Alias Beurla de Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-manopyranosyl-(1-> 2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- > 2) -O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b, 6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
