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Description: glucoridin is an isoflavane from glycorrhiza glabra, which can bind and activate PPAR γ， The EC50 value is 6115 nm. Glabridin has antioxidant, antibacterial, anti glomerulonephritis, anti diabetes, anti-tumor, anti-inflammatory, anti osteoporosis, protect cardiovascular, protect the nerves, scavenge free radicals and other functions.

Related Categories: research field > > cancer
Signaling pathway > > cell cycle / DNA damage > > PPAR
Research field > > inflammation / immunity

In Vitro Study: glabridin binds and activates PPAR γ， EC50 is 6115 nm [1]. Glabridin（40,80 μ M) The proliferation of SCC-9 and SAS cell lines was inhibited in a dose and time-dependent manner after 24 and 48 hours of treatment [2]. Glabridin（0-80 μ M) It also induces apoptosis, leading to sub G1 cell cycle arrest in SCC-9 and SAS cell lines [2]. Glabridin (0,20,40 and 80 μ M) Dose dependently activated Caspase-3, - 8 and - 9 and increased PARP cleavage, significantly phosphorylating ERK1 / 2, JNK1 / 2 and P-38 MAPK in SCC-9. Cells [2].

In Vivo Study: glabridin (50 mg / kg, Po once daily) showed strong anti-inflammatory activity and improved the inflammatory changes induced by dextran sodium sulfate (DSS) [3]

References: [1]  Rebhun JF, et al. Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPAR γ). Fitoterapia. 2015 Oct; 106:55-61.
[2].  Chen CT, et al. Glabridin induces apoptosis and cell cycle arrest in oral cancer cells through the JNK1/2 signaling pathway. Environ Toxicol. 2018 Jun; 33(6):679-685.
[3]. El-Ashmawy NE, et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr; 26(2):551-559.