Good Quality Astragaloside IV - Isoliquiritin Apioside – Yongjian
Good Quality Astragaloside IV - Isoliquiritin Apioside – Yongjian Detail:
Application of Isoliquiritin Apioside
Isoliquiritin apioside, a component isolated from glycorrhizae radio rhome, significantly reduced PMA induced increase in MMP9 activity and inhibited PMA induced MAPK and NF- κ B activation. Isoliquitin apioside inhibits the invasion and angiogenesis of cancer cells and endothelial cells.
Name of Isoliquiritin Apioside
Chinese Name: Isoliquiritin Apioside
English Name: (E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Bioactivity of Isoliquiritin Apioside
Description: isoliquitin apioside, a component isolated from glycorrhizae radio rhome, significantly reduced PMA induced increase in MMP9 activity and inhibited PMA induced MAPK and NF- κ B activation. Isoliquitin apioside inhibits the invasion and angiogenesis of cancer cells and endothelial cells.
Related Categories: research field > > cancer
Signal path > > MAPK / ERK signal path > > p38 MAPK
Signaling pathway > > metabolic enzyme / protease > > MMP
Target: MMP9
NF-κB
p38 MAPK
In vitro study: isorlicin could effectively inhibit the gelation MMP-9 activity of PMA induced HT1080 cells. Isoglycyrrhizin apigenin reduces the increase of MMP-9 production in HT1080 cells induced by PMA, has the ability of anti metastasis and anti angiogenesis in malignant tumor cells and endothelial cells, and has no cytotoxicity [1].
Reference: [1]. Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455.
Physicochemical properties of Isoliquiritin Apioside
Density: 1.6 ± 0.1 g / cm3
Boiling point: 901.0 ± 65.0 ° C at 760 mmHg
Molecular formula: c26h30o13
Molecular weight: 550.509
Flash point: 301.9 ± 27.8 ° C
Accurate mass: 550.168640
PSA:215.83000
LogP:1.96
Steam pressure: 0.0 ± 0.3 mmHg at 25 ° C
Refractive index: 1.709
English alias of Isoliquiritin Apioside
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl)-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
Product detail pictures:
Related Product Guide:
We've been convinced that with joint efforts, the enterprise between us will bring us mutual benefits. We could guarantee you item excellent and aggressive price tag for Good Quality Astragaloside IV - Isoliquiritin Apioside – Yongjian , The product will supply to all over the world, such as: Argentina, United States, Macedonia, Our R&D department always designs with new fashion ideas so we could introduce up-to-date fashion styles every month. Our strict production management systems always ensure stable and high quality products. Our trade team provides timely and efficient services. If there are any interest and inquiry about our products, please contact us in time. We would like to establish a business relationship with your honored company.
By Dominic from Paraguay - 2018.06.09 12:42
The company's products very well, we have purchased and cooperated many times, fair price and assured quality, in short, this is a trustworthy company!
By Abigail from Leicester - 2018.11.02 11:11