page_head_bg

Products

Good User Reputation for Glycitein - Salvianolic acid C – Yongjian

Short Description:


Product Detail

Product Tags

Related Video

Feedback (2)

All we do is usually connected with our tenet " Consumer initial, Rely on 1st, devoting around the food stuff packaging and environmental safety for Cas No.604-80-8 Narcissin , Forsythin , Glychionide A , We have been normally seeking forward to forming profitable company relationships with new clientele around the environment.
Good User Reputation for Glycitein - Salvianolic acid C – Yongjian Detail:

Purpose

Salvianolic acid C is a non competitive inhibitor of cytochrome p4502c8 (cyp2c8) and a mixed inhibitor of cytochrome P4502J2 (CYP2J2) with medium intensity. Its Ki values for cyp2c8 and CYP2J2 are 4.82 respectively μ M and 5.75 μ M

English Name

(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2-propenoyl}oxy)propanoic acid

English Alias

(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2-enoyl}oxy)propanoic acid
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2-propenoyl}oxy)propanoic acid
Benzenepropanoic acid, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3,4-dihydroxy-, (αR)-
Salvianolic acid C

Physicochemical Properties Of Salvianolic Acid C

Density: 1.6 ± 0.1 g / cm3

Boiling Point: 844.2 ± 65.0 ° C at 760 mmHg

Molecular Formula: C26H20O10

Molecular Weight: 492.431

Flash point: 464.4 ± 34.3 ° C

Exact Mass: 492.105652

PSA:177.89000

LogP: 3.12

Steam Pressure: 0.0 ± 3.3 mmHg at 25 ° C

Refractive index: 1.752

Bioactivity Of Salvianolic Acid C

Description:
Salvianolic acid C is a non competitive inhibitor of cytochrome p4502c8 (cyp2c8) and a mixed inhibitor of cytochrome P4502J2 (CYP2J2) with medium intensity. Its Ki values for cyp2c8 and CYP2J2 are 4.82 respectively μ M and 5.75 μ M。

Relevant categories:
Signaling pathway > > metabolic enzyme / protease > > cytochrome P450
Research field > > cancer
Natural Products > > others

Target:
CYP2C8:4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)

In Vitro Study:
Salvianolic acid C is a moderate mixed inhibitor of non competitive cyp2c8 inhibitor and CYP2J2. The KIS of cyp2c8 and CYP2J2 are 4.82 and 5.75 respectively μ M[1]。 1 and 5 μ M salvianolic acid C (SALC) can significantly inhibit LPS induced no production. Salvianolic acid C significantly reduced the expression of iNOS. Salvianolic acid C inhibits LPS induced TNF- α, IL-1 β, IL-6 and IL-10 were overproduced. Salvianolic acid C inhibits LPS induced NF- κ B activation. Salvianolic acid C also increased the expression of Nrf2 and HO-1 in BV2 microglia [2].

In Vivo Studies:
Salvianolic acid C (20mg / kg) treatment significantly reduced the escape latency. In addition, SALC (10 and 20 mg / kg) treatment significantly increased the number of platform crossings compared with LPS model group. Compared with the model group, systemic administration of salvianolic acid C down regulated brain TNF- α, IL-1 β And IL-6 levels. The levels of iNOS and COX-2 in the cerebral cortex and hippocampus of rats were higher than those in the control group, while salvianolic acid C treatment significantly down regulated the cortex and hippocampus. Salvianolic acid C (5, 10 and 20 mg / kg) treatment increased p-ampk, Nrf2, HO-1 and NQO1 levels in rat cerebral cortex and hippocampus in a dose-dependent manner [2].

Reference:
[1].  Xu MJ, et al. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. Chem Biol Interact. 2018 Jun 1; 289:15-22.
[2].  Song J, et al. Activation of Nrf2 signaling by salvianolic acid C attenuates NF κ B mediated inflammatory response both in vivo and in vitro. Int Immunopharmacol. 2018 Oct; 63:299-310.


Product detail pictures:

Good User Reputation for Glycitein - Salvianolic acid C –  Yongjian detail pictures


Related Product Guide:

Our corporation insists all along the quality policy of "product top quality is base of organization survival; purchaser pleasure will be the staring point and ending of an company; persistent improvement is eternal pursuit of staff" plus the consistent purpose of "reputation very first, purchaser first" for Good User Reputation for Glycitein - Salvianolic acid C – Yongjian , The product will supply to all over the world, such as: panama, Turkey, Uzbekistan, We are confident that we are able to provide you with opportunities and will be a valuable business partner of you. We look forward to working with you soon. Learn more about the types of products that we work with or contact us now directly with your inquiries. You are welcome to contact us anytime!
  • Speaking of this cooperation with the Chinese manufacturer, I just want to say"well dodne", we are very satisfied.
    5 Stars By Amelia from Pakistan - 2017.08.18 11:04
    This company conforms to the market requirement and joins in the market competition by its high quality product, this is an enterprise that have Chinese spirit.
    5 Stars By Jean from Bulgaria - 2017.12.31 14:53
    Write your message here and send it to us