3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin.
Amfani da Methylnissolin
Methylnisolin (strapterocarpan) an ware shi daga Astragalus membranaceus kuma zai iya hana yaduwar kwayar halitta ta hanyar haɓakar haɓakar platelet (PDGF) - BB, tare da IC50 na 10 μ M. Methylnisolin yana hana phosphorylation na siginar extracellular / 1 kinaseeric1 2) furotin da aka kunna mitogen (taswira) kinase wanda PDGF-BB ya jawo.Methylnisolin yana hana PDGF-BB haifar da haɓakar ƙwayoyin tsoka mai santsi na jijiyoyin jini ta hanyar hana ERK1 / 2 MAP kinase cascade.
Sunan mahaifi Methylnissolin
Sunan Ingilishi:
(- -6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c] [1] - benzopyran
Laƙabin Sinanci: 3-hydroxy-9,10-dimethoxy jan sandalwood |Astragalus ja
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy jan sandalwood
Ayyukan Halittu na Methylnissolin
Bayani: methylnisolin (astrapterocarpan) an ware shi daga Astragalus membranaceus
kuma zai iya hana yaduwar kwayar halitta wanda aka haifar ta hanyar haɓakar haɓakar platelet (PDGF) - BB.
IC50 shine 10 μM. Methylnisolin yana hana phosphorylation na siginar salula
tsarin kinase 1/2 (eric1/2) furotin da aka kunna mitogen (taswira) kinase wanda ya jawo ta
PDGF-BB.Methylnisolin yana hana PDGF-BB haifar da yaduwa na jijiyoyin jini santsi
Kwayoyin tsoka ta hanyar hana ERK1 / 2 MAP kinase cascade.
Categories masu alaƙa: filin bincike > > cututtukan zuciya
Hanyar sigina > > furotin tyrosine kinase > > PDGFR
Hanyar sigina > > MAPK / Hanyar siginar ERK > > ERK
Hanyar sigina > > sel mai tushe da hanyar Wnt > > ERK
Bala'i: PDGFR: 10 μM (IC50)
ERK1
ERK2
Magana:[1].Ohkawara S, et al.Astrapterocarpan ware daga Astragalus membranaceus yana hana yaduwar ƙwayoyin tsoka mai santsi.Farashin J Pharmacol.2005 Nuwamba 21; 525 (1-3): 41-7.
Physicochemical Properties na Methylnissolin
Girma: 1.3 ± 0.1 g / cm3
Tushen tafasa: 428.9 ± 45.0 ° C a 760 mmHg
Molecular Formula: c17h16o5
Nauyin Kwayoyin: 300.306
Wutar Wuta: 213.2 ± 28.7 ° C
Madaidaicin Mass: 300.099762
Saukewa: 57.15000
Shafin: 2.45
Matsin lamba: 0.0 ± 1.1 mmHg a 25 ° C
Shafin Farko: 1.612
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., kafa a watan Maris 2012, ne a high-tech sha'anin hadawa R & D, samarwa da kuma tallace-tallace.Ya fi tsunduma cikin samarwa, gyare-gyare da kuma samar da tsarin samar da abubuwa masu aiki na samfuran halitta, kayan tuntuɓar magungunan gargajiya na kasar Sin da ƙazantattun magunguna.Kamfanin yana cikin birnin kasar Sin Pharmaceutical City, birnin Taizhou, lardin Jiangsu, ciki har da samar da murabba'in mita 5000 da kuma 2000 murabba'in mita R & D tushe.Ya fi ba da hidima ga manyan cibiyoyin bincike na kimiyya, jami'o'i da masana'antun sarrafa kayan kwalliya a duk faɗin ƙasar.
Ya zuwa yanzu, mun ɓullo da fiye da 1500 iri na halitta fili reagents, kuma idan aka kwatanta da calibrated fiye da 300 nau'i na tunani kayan, wanda zai iya cika cika da yau da kullum dubawa bukatun na manyan kimiyya cibiyoyin bincike, jami'a dakunan gwaje-gwaje da decoction guda samar Enterprises.
Dangane da ka'idar bangaskiya mai kyau, kamfanin yana fatan yin aiki tare da abokan cinikinmu da gaske.Manufarmu ita ce hidimar zamanantar da magungunan gargajiya na kasar Sin.
Amfanin Kasuwancin Kasuwancin Kamfanin
1. R & D, samarwa da tallace-tallace na kayan bincike na magungunan gargajiya na kasar Sin;
2. Keɓaɓɓen magungunan gargajiya na kasar Sin monomer mahadi bisa ga halayen abokin ciniki
3. Bincike a kan ingancin ma'auni da tsarin ci gaba na maganin gargajiya na kasar Sin (shuka).
4. Haɗin gwiwar fasaha, canja wuri da sabon bincike da ci gaba na miyagun ƙwayoyi.
