Kayayyaki

Bayani:monoammonium glycyrrhizinate hydrate yana da ayyukan harhada magunguna kamar su anti-mai kumburi, antiallergic, anti-gastrointestinal ulcer da anti hepatitis.

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Filin bincike > > kumburi / rigakafi

A cikin Nazarin Vivo:karuwar huhu w / D nauyi rabo ya ragu sosai ta hanyar gudanar da manyan allurai da matsakaici na mag (10 da 30 mg / kg).Pretreatment da mag (10 da 30 mg / kg) yadda ya kamata rage TNF- α Da IL-1 β Generation na.Mag (10,30 mg / kg) ya rage NF sosai idan aka kwatanta da LPS-κ Bp65 furcin furotin.Sabanin haka, LPS ya rage ni sosai idan aka kwatanta da ƙungiyar kulawa κ B- α Protein magana, yayin da mag (10 da 30 mg / kg) ya karu sosai I κ B- α Expression [1].Idan aka kwatanta da ƙungiyoyin RIF da INH, ƙananan ƙwayar cuta da kuma maganin MAG mai mahimmanci sun rage ast, alt, TBIL da matakan TBA a 14 da 21 kwanakin, yana nuna tasirin kariya na MAG akan RIF - da INH -.Sanya raunin hanta.Ƙungiyar kula da MAG ta karu matakin GSH hanta a 7, 14 da 21 days, kuma an rage girman matakin MDA a 14 da 21 kwanaki a RIF da INH da aka kula da berayen, yana nuna tasirin kariya na MAG a cikin RIF - da.INH ta haifar da raunin hanta [2].

Gwajin Dabbobi:mice [1] a cikin wannan binciken, BALB / c mice (namiji, 6-8 makonni, 20-25g) an yi amfani da su.An raba berayen bazuwar zuwa ƙungiyoyi 5: ƙungiyar kulawa, ƙungiyar LPS da LPS + monoammonium glycyrrhizinate (Mag: 3,10 da 30mg / kg).Kowane rukuni ya ƙunshi mice 8.An yi wa beraye maganin alurar riga kafi tare da allurar intraperitoneal na pentobarbital sodium (50 mg / kg).An yi wa beraye allura ta ciki tare da mag (3, 10 da 30 mg / kg) kafin haifar da mummunan rauni na huhu.Bayan awa 1, an yi wa LPS (5 mg / kg) allura a cikin intracheal don haifar da mummunan rauni na huhu.An ba da beraye na yau da kullun PBS [1].Berayen [2] sun yi amfani da berayen Wistar maza (180-220g).An raba berayen bazuwar zuwa ƙungiyoyin 4: ƙungiyar kulawa, RIF da ƙungiyar INH, ƙungiyar ƙarancin ƙima da MAG, tare da berayen 15 a kowace ƙungiya.An ba da berayen a cikin RIF da ƙungiyoyin INH RIF (60mg / kg) da INH (60mg / kg) ta hanyar gavage sau ɗaya a rana;Rats a cikin rukunin MAG an riga an yi musu maganin MAG a kashi na 45 ko 90 mg / kg, kuma RIF (60 mg / kg) da INH (60 mg / kg) an ba su sa'o'i 3 bayan gudanar da MAG;An bi da berayen da ke cikin rukunin kulawa da saline na yau da kullun.Don kimanta tasirin tasirin maganin, an kashe berayen a kowane rukuni 7, 14 da 21 kwanaki bayan gudanarwa [2].

Magana:1].Huang X, et al.Hanyoyin Anti-inflammatory na Monoammonium Glycyrrhizinate akan Lipopolysaccharide-Induced Mummunan Raunin Huhu a cikin Mice ta Hanyar Gudanar da Nukiliya-Kappa B Hanyar Siginar.Evid Based Complement Alternat Med.2015;2015:272474.
[2].Zhou L, et al.Monoammonium glycyrrhizinate yana kare rifampicin- da isoniazid-induced hepatotoxicity ta hanyar daidaita maganganun jigilar Mrp2, Ntcp, da Oatp1a4 a cikin hanta.Pharm Biol.2016;54 (6): 931-7.