Astragaloside IV CAS Lamba 84687-43-4
Takaitaccen Gabatarwa
Harshen Turanci:Astragaloside IV;beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R) -20,24-epoxy-16,25-dihydroxy-3- (beta-D-xylopyranosyloxy) -9,19-cyclolanostan-6-yl;(3beta,6alpha,9beta,16beta,20R,24S) -16,25-dihydroxy-3-(beta-D-xylopyranosyloxy) -20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-threo - hexopyranoside
Tsarin kwayoyin halitta:Saukewa: C41H68O14
Sunan Sinadari:17-[5- (1-Hydroxyl-1-methyl-ethyl)- 2methyl-tetrahydro- furan-2-yl] -4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10] cyclopenta[a] phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D- glucoside
Mp:200-204 ℃
[a]D:-56.6(c,0.13 in DMF)
UV:max 203 nm
tsarki:98%
Source:Legume Astragalus membranaceus, Astragalus pubescens.
Tsarin tsarin sinadarai na astragaloside IV
Properties na Physicochemical
[bayani]:farin crystalline foda
[tsarki]:sama da 98%, hanyar ganowa: HPLC
[tushen shuka]:Tushen Astragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) Tushen Bungede, Astragalus sieversianus Pall Tushen Astragalus spinosus Vahl, ɓangaren iska na Astragalus spinosus Vahl.
[kayan samfurin]:Astragalus membranaceus tsantsa shine launin ruwan rawaya foda.
[ƙaddamar da abun ciki]:ƙayyade ta HPLC (Shafi VI D, Juzu'i na I, Pharmacopoeia na Sinanci, 2010 Edition).
Yanayi na chromatographic da gwajin aikace-aikacen tsarin} octadecyl silane bonded silica gel Ana amfani dashi azaman filler, ruwan acetonitrile (32:68) ana amfani dashi azaman lokacin wayar hannu, kuma ana amfani da mai gano watsawar haske don ganowa.Yawan faranti na ka'idar ba zai zama ƙasa da 4000 ba bisa ga astragaloside IV kololuwa.
Shirye-shiryen bayani mai mahimmanci, ɗauki adadin da ya dace na astragaloside IV tunani, auna shi daidai, kuma ƙara methanol don shirya wani bayani mai dauke da 0.5mg a kowace 1ml.
Shirye-shiryen maganin gwaji:a dauki kamar 4G na foda daga wannan samfurin, auna shi daidai, saka shi a cikin Soxhlet extractor, ƙara 40ml na methanol, jiƙa shi cikin dare, ƙara adadin methanol da ya dace, zafi da reflux na 4 hours, dawo da sauran ƙarfi daga tsantsa kuma mayar da hankali. sai a bushe sai a zuba ruwa 10ml a narkar da ragowar sai a girgiza a cire shi da cikakken n-butanol sau 4, 40ml kowane lokaci, sai a hada maganin n-butanol, sannan a wanke shi da maganin ammonia har sau 2, 40ml kowanne. lokaci, jefar da maganin ammonia, zubar da maganin n-butanol, ƙara 5ml ruwa don narkar da ragowar, da kuma kwantar da shi, Ta hanyar D101 macroporous adsorption resin ginshiƙi (diamita na ciki: 37.5px, shafi tsawo: 300px), elute tare da 50ml na ruwa. , jefar da maganin ruwan, a zubar da 30ml na 40% ethanol, jefar da eluent, elute tare da 80ml na 70% ethanol, tattara eluent, kwashe shi zuwa bushewa, narkar da ragowar da methanol, canja shi zuwa 5ml volumetric flask, ƙara. methanol zuwa sikelin, girgiza da kyau, kumato samu.
Hanyar tantancewa:daidai sha 10% na bayani bayani bi da bi μl, 20 μl.Gwajin maganin 20 kowane μl.Allurar da shi a cikin chromatograph na ruwa, tantance shi, da lissafta shi tare da ma'aunin logarithm na daidaitaccen hanya mai maki biyu na waje.
An ƙididdige shi azaman samfurin busassun, abun ciki na astragaloside IV (c41h68o14) bazai zama ƙasa da 0.040%
Ayyukan Pharmacological
Babban tasiri na Astragalus shine polysaccharides da astragaloside.An raba Astragaloside zuwa astragaloside I, astragaloside II da astragaloside IV.Daga cikin su, astragaloside IV, astragaloside IV, yana da mafi kyawun aikin ilimin halitta.Astragaloside IV ba wai kawai yana da tasirin Astragalus polysaccharides ba, har ma da wasu abubuwan da ba su misaltuwa na Astragalus polysaccharides.Ƙarfin ƙarfinsa ya fi sau biyu fiye da na al'ada astragalus polysaccharides, kuma tasirin antiviral shine sau 30 na Astragalus polysaccharides.Saboda ƙarancin abun ciki da sakamako mai kyau, ana kuma san shi da "super astragalus polysaccharide".
1.Ingantattun rigakafi da juriya na cututtuka.
Yana iya keɓance na musamman da ba na musamman ba na waje waɗanda ke mamaye jiki, haɓaka takamaiman, rigakafi da ƙayyadaddun rigakafi, da haɓaka juriya na cuta na jiki.Yana iya haɓaka samar da maganin rigakafi, kuma yana haɓaka yawan adadin ƙwayoyin da ke haifar da ƙwayoyin cuta da ƙimar gwajin haemolysis.Astragaloside IV na iya inganta haɓaka matakin canjin lymphocyte da ƙimar samuwar E-rosette na kajin rigakafin coccidia.Yana da tasiri mai kunnawa na tsarin macrophage monocyte.Astragaloside IV kuma na iya inganta haɓakar iskar oxygen, GSH-Px da ayyukan SOD a cikin gabobin na rigakafi, da haɓaka ayyukan tsaro na rigakafi da ayyukan kulawa na rigakafi.
2.Antiviral sakamako.
Its antiviral ka'idar: ta da aiki na macrophages da T Kwayoyin, ƙara yawan E-ring forming Kwayoyin, sa cytokines, inganta shigar da interleukin, da kuma sa jikin dabba samar da endogenous interferon, don cimma manufar antiviral.Sakamakon ya nuna cewa jimlar adadin kariya na astragaloside IV akan IBD shine 98.33%, wanda zai iya hanawa da kuma bi da IBD yadda ya kamata, kuma babu wani bambanci mai mahimmanci idan aka kwatanta da babban maganin kwai gwaiduwa.Astragaloside na iya haɓaka aikin enzymes antioxidant a cikin jiki, rage abun ciki na LP0, rage lalacewar nau'in oxygen mai amsawa, don haka rage yawan abin da ya faru da mace-mace na MD.Zai iya inganta ƙananan aikin rigakafi da ƙwayar cuta ta haifar, inganta kunnawa na ƙwayoyin cuta, saki abubuwan da ke cikin jiki, da kuma hana kashewa da hana ƙwayar ƙwayar cuta ta hanyar peroxidation;Astragaloside a na iya hana ci gaban cutar mura da aikin sialidase.Yana da tasiri mai mahimmanci akan aikin ƙwayar ƙwayar ƙwayar cuta ta ƙwayar ƙwayar cuta da kuma tallatawa da shigar da ƙwayoyin cuta zuwa ƙwayoyin cuta.Yawan mace-mace da kwai na kaji ya ragu sosai, kuma yawan zubar da kwai da kuma dawo da ingancin kwai sun fi na amantadine kawai mai kula da su, kuma tasirin Astragalus polysaccharide bai fito fili ba;Astragaloside IV yana da karfi kisa da tasirin hanawa akan kwayar cutar.Jigon shi ne cewa yin amfani da astragaloside IV shine kafin gano kamuwa da cuta tare da Nd virus, don haka yana da kyau a yi amfani da astragaloside IV na dogon lokaci, Avian myeloblastic leukemia (AMB) 3 days old AA broilers ciyar da astragaloside IV tare da kamuwa da cuta. Kwayar cutar AMB, na iya rage yawan aukuwa da mace-mace na AMB, ƙara yawan abun ciki na LPO a cikin gabobin rigakafi kamar su splin da thymus, yana haɓaka tasirin ɓarnawar ƙwayar cuta da thymus da sauran gabobin rigakafi akan ƙwayoyin tumor da aka samu myeloid.Abu na biyu, astragaloside IV yana da tabbataccen rigakafi da tasirin warkewa akan cututtukan numfashi kamar laryngotracheitis mai kamuwa da cuta.Amfani.
3. Anti danniya sakamako.
Astragaloside IV na iya hana hyperplasia na adrenal da thymus atrophy a cikin lokacin gargadi na amsawar damuwa, da kuma hana canje-canje mara kyau a cikin lokacin juriya da kuma lokacin gazawar amsawar damuwa, don yin taka rawar anti danniya, musamman ma yana da mahimman tsari guda biyu. tasiri a kan enzymes a cikin tsarin tafiyar da abinci mai gina jiki, kuma yana ragewa da kuma kawar da tasirin zafi a kan aikin physiological na jiki zuwa wani matsayi.
4. A matsayin mai bunkasa girma.
Yana iya haɓaka haɓakar ƙwayoyin cuta na physiological na sel, haɓaka zagayawa na jini, haɓaka metabolism na jikin dabba, kuma yana taka rawar abinci mai gina jiki da kula da lafiya.Bincike ya nuna cewa zai iya inganta ci gaban bifidobacteria da kwayoyin lactic acid kuma yana da tasirin probiotics.
5. Astragaloside IV na iya inganta aikin zuciya na zuciya.
Ƙarfafa ƙaddamarwar zuciya, kare myocardium da tsayayya da gazawar zuciya.Hakanan yana da tasirin kare hanta, maganin kumburi da analgesic.Ana iya amfani da shi azaman maganin adjuvant don cututtuka daban-daban na ƙwayoyin cuta da ƙwayoyin cuta.
