Chlorogenic Acid CAS No.327-97-9
Bayani mai mahimmanci
Chlorogenic acid yana da nau'ikan tasirin ƙwayoyin cuta, amma ana iya kashe shi ta hanyar sunadaran a vivo.Mai kama da caffeic acid, na baka ko allurar intraperitoneal na iya inganta haɓakar tsakiyar berayen.Yana iya ƙara ɓarnar hanji na berayen da beraye da tashin hankalin mahaifar bera.Yana da tasirin cholagogic kuma yana iya haɓaka ƙwayar bile a cikin berayen.Yana da tasiri a kan mutane.Asthma da dermatitis na iya faruwa bayan shakar ƙurar shuka mai ɗauke da wannan samfur.
Sunan Sinanci: Chlorogenic acid
Sunan waje: Chlorogenic acid
Tsarin Sinadarai: C16H18O9
Nauyin Kwayoyin Halitta: 354.31
Lambar CAS: 327-97-9
Matsayin narkewa: 208 ℃;
Tushen tafasa: 665 ℃;
Maɗaukaki: 1.65 g / cm ³
Wutar Wuta: 245.5 ℃
Fihirisar Rarraba: - 37 °
Bayanan Toxicology
Mummunan guba: ƙarancin kisa (bera, rami na ciki) 4000mg/kg
Bayanan Halitta
Sauran illa masu illa: abu na iya zama cutarwa ga muhalli, kuma ya kamata a ba da kulawa ta musamman ga ruwa.
Source
Eucommia ulmoides Oliv Lonicera dasytyla Rehd Busassun furen fure ko tare da furanni masu fure, 'ya'yan itacen Hawthorn na Biritaniya a cikin Rosaceae, farin kabeji a cikin dioscoreaceae, Salix mandshurica a cikin Apocynaceae, Polypodiaceae shuka Eurasian ruwa keel rhizomenia da tsire-tsire masu tsire-tsire masu tsire-tsire. , Polygonaceae shuka lebur ajiya dukan ciyawa, Rubiaceae shuka tarpaulin dukan ciyawa, honeysuckle shuka capsule Zhai Dukan ciyawa.Ganyen dankalin turawa a cikin dangin Convolvulaceae.Tsaba na ƙananan kofi na 'ya'yan itace, kofi na 'ya'yan itace matsakaici da babban kofi na 'ya'yan itace.Ganyayyaki da tushen Arctium lappa
Amfani da Chlorogenic Acid
Chlorogenic acid yana da kewayon ayyukan nazarin halittu.Bincike kan ayyukan nazarin halittu na chlorogenic acid a kimiyyar zamani ya zurfafa a fannoni da dama, kamar abinci, kiwon lafiya, magani, masana'antar sinadarai ta yau da kullun da sauransu.Chlorogenic acid wani abu ne mai mahimmanci na bioactive, wanda yana da ayyuka na antibacterial, antiviral, ƙara leukocyte, kare hanta da gallbladder, anti-tumor, rage karfin jini, rage yawan lipid jini, zubar da radicals kyauta da kuma ban sha'awa ga tsarin kulawa na tsakiya.
Antibacterial da antiviral
Eucommia ulmoides chlorogenic acid yana da tasiri mai karfi na antibacterial da anti-inflammatory, aucubin da polymers suna da tasirin kwayoyin cuta a fili, kuma aucubin yana da tasirin hanawa akan kwayoyin Gram-negative da tabbatacce.Aucubin yana da tasirin bacteriostatic da diuretic, kuma yana iya inganta warkar da raunuka;Aucubin da glucoside kuma na iya haifar da tasirin rigakafin cutar sankara a bayyane bayan al'adar farko, amma ba ta da aikin rigakafin cutar.Cibiyar Kimiyyar Kiwon Lafiya ta tsufa, Jami'ar Kiwon Lafiya ta Aichi, ta tabbatar da cewa sinadarin alkaline da aka fitar daga Eucommia ulmoides Oliv.Yana da ikon lalata ƙwayoyin cuta na tsarin garkuwar jikin ɗan adam.Ana iya amfani da wannan abu don rigakafi da kuma magance cutar kanjamau.
Antioxidation
Chlorogenic acid ne mai tasiri phenolic antioxidant antioxidant.Ƙarfin antioxidant ɗin sa ya fi ƙarfin caffeic acid, p-hydroxybenzoic acid, ferulic acid, syringic acid, butyl hydroxyanisole (BHA) da tocopherol.Chlorogenic acid yana da sakamako na antioxidant saboda ya ƙunshi wani adadin R-OH radical, wanda zai iya samar da hydrogen radical tare da tasirin antioxidant, don kawar da ayyukan hydroxyl radical, superoxide anion da sauran free radicals, don kare kyallen takarda daga oxidative. lalacewa.
Free radical scavenging, anti-tsufa, anti musculoskeletal tsufa
Chlorogenic acid da abubuwan da suka samo asali suna da sakamako mai ƙarfi na radical kyauta fiye da ascorbic acid, caffeic acid da tocopherol (bitamin E), na iya lalata DPPH kyauta mai kyau, hydroxyl free radical da superoxide anion free radical, kuma yana iya hana iskar shaka na low-yawa. lipoprotein.Chlorogenic acid yana taka muhimmiyar rawa wajen kawar da radicals kyauta, kiyaye tsarin al'ada da aikin kwayoyin jikin mutum, hanawa da jinkirta faruwar maye gurbi da tsufa.Eucommia chlorogenic acid yana ƙunshe da wani sashi na musamman wanda zai iya inganta haɓakawa da bazuwar collagen a cikin fata, kashi da tsoka.Yana da aikin haɓaka metabolism da hana raguwa.Ana iya amfani da shi don hana raguwar kashi da tsoka da rashin nauyin sararin samaniya ke haifarwa.A lokaci guda, an gano cewa Eucommia chlorogenic acid yana da tasirin anti-free radical a fili duka a cikin vivo da in vitro.
Hana maye gurbi da antitumor
Gwaje-gwajen harhada magunguna na zamani sun tabbatar da cewa Eucommia ulmoides chlorogenic acid yana da tasirin maganin ciwon daji da kuma ciwon daji.Masanan Jafananci sun yi nazarin antimutagenicity na Eucommia ulmoides chlorogenic acid kuma sun gano cewa wannan tasirin yana da alaƙa da abubuwan anti mutagenic kamar chlorogenic acid, yana bayyana mahimmancin chlorogenic acid a cikin rigakafin ƙari.
Polyphenols a cikin kayan lambu da 'ya'yan itatuwa, irin su chlorogenic acid da caffeic acid, na iya hana mutagenicity na carcinogens aflatoxin B1 da benzo [a] - pyrene ta hanyar hana enzymes da aka kunna;Chlorogenic acid kuma zai iya cimma maganin cutar kansa da kuma maganin cutar kansa ta hanyar rage amfani da carcinogens da jigilar su a cikin hanta.Chlorogenic acid yana da tasiri mai mahimmanci na hanawa akan ciwon daji na colorectal, ciwon hanta da ciwon makogwaro.Ana la'akari da shi azaman madaidaicin sinadari mai kariya daga cutar kansa.
Tasirin kariya akan tsarin zuciya da jijiyoyin jini
A matsayin mai ɓarna mai ɓacin rai da antioxidant, chlorogenic acid an tabbatar da shi ta babban adadin gwaje-gwaje.Wannan aikin nazarin halittu na chlorogenic acid zai iya kare tsarin zuciya da jijiyoyin jini.Isochlorogenic acid B yana da tasiri mai karfi a kan inganta sakin prostacyclin (PGI2) da kuma antiplatelet aggregation a cikin berayen;Adadin hanawa na sakin SRS-A wanda antibody ya haifar da tarkacen huhun alade shine 62.3%.Isochlorogenic acid C kuma ya inganta sakin PGI2.Bugu da ƙari, isochlorogenic acid B yana da tasirin hanawa mai ƙarfi akan platelet thromboxane biosynthesis da raunin endothelin wanda hydrogen peroxide ya haifar.
Tasirin hypotensive
An tabbatar da shekaru da yawa na gwaje-gwaje na asibiti cewa Eucommia chlorogenic acid yana da tasirin antihypertensive a fili, ingantaccen maganin warkewa, mara guba kuma babu illa.Jami'ar Wisconsin ta gano cewa ingantattun abubuwan Eucommia ulmoides kore don rage hawan jini sune terpineol diglucoside, aucubin, chlorogenic acid, da Eucommia ulmoides chlorogenic acid polysaccharides.[5]
Sauran ayyukan halitta
Saboda chlorogenic acid yana da tasirin hanawa na musamman akan hyaluronic acid (HAase) da glucose-6-phosphatase (gl-6-pase), chlorogenic acid yana da wani tasiri akan warkar da rauni, lafiyar fata da wetting, lubricating gidajen abinci, hana kumburi da daidaita ma'auni na glucose na jini a cikin jiki.Chlorogenic acid yana da tasirin hanawa mai ƙarfi da kuma kisa akan nau'ikan cututtuka da ƙwayoyin cuta.Chlorogenic acid yana da tasirin magunguna na rage karfin jini, antibacterial, antiviral, anti-inflammatory, kara yawan farin jini, hana ciwon sukari, haɓaka motsin gastrointestinal da inganta ƙwayar ciki.Nazarin ya nuna cewa chlorogenic acid na baka na iya kara kuzari sosai da fitar bile kuma yana da tasirin amfanar gallbladder da kare hanta;Hakanan yana iya hana hemolysis na erythrocytes na berayen da H2O2 ke haifarwa.