Cycloastragenol CAS Lamba 78574-94-4
Ƙayyadaddun samfur
[suna]:cycloastragalus barasa
[lalata]:triterpenoid cyclic flavonol
[Sunan Turanci]:cycloastragenol
[Molecular formula]:Saukewa: C30H50O5
[nauyin kwayoyin halitta]:490.71
[CAS No.]:78574-94-4
[hanyar ganowa]:HPLC ≥ 98%
[Kayyadewa]:20mg 50mg 100mg 500mg 1g (za a iya kunshe bisa ga abokin ciniki bukatun)
[kayayyaki]:wannan samfurin crystal acicular mara launi
[aiki da amfani]:Ana amfani da wannan samfurin don tantance abun ciki, ganowa, gwajin harhada magunguna, tantance ayyuka da sauran gwaje-gwajen bincike na kimiyya.Kamar sarrafa kwayar halitta, gwajin ciki, gwajin ingancin ciki na masana'antar harhada magunguna, da sauransu.Source: Astragalus membranaceus (Fisch.) Bge.Bushewar cirewar tushen
Hanyar Ajiya
2-8 ° C, an rufe shi daga haske kuma an adana shi a ƙananan zafin jiki.
Lura
Ya kamata a adana wannan samfurin a ƙananan zafin jiki.Idan an fallasa shi zuwa iska na dogon lokaci, za a rage abun ciki.
Yanayi na chromatographic} shafi na chromatographic: Zorbax rx-c18 (4.6mm) × 150mm), 5 μ m; Lokacin wayar hannu: ruwan acetonitrile (30:70);Yawan gudu: 1.0ml/min, shafi zafin jiki: 35 ℃, ELSD sigogi: drift tube zazzabi: 105 ℃, nitrogen kwarara kudi: 2.70ml/min.
Kaddarorin Physicochemical: yawa 1.20
Bioactivity na cycloastragenol
Cycloastragalol wani fili ne na triterpene saponin, wanda shine Astragalus membranaceus (Fisch.) Hydrolyzate na kayan aiki mai aiki a Bunge).Astramembrangenin yana da aminci na baka kuma yana da nau'ikan tasirin harhada magunguna, gami da kunna telomerase, tsawaita telomere, anti-mai kumburi da kaddarorin antioxidant.Astramembrangenin yana da kaddarorin anti-tsufa.CAG yana ƙarfafa ayyukan telomerase a cikin keratinocytes jarirai na ɗan adam da ƙwayoyin jijiya na bera kuma yana haifar da kunna CREB.Astramembrangenin na iya samun sabon tasirin warkewa a cikin baƙin ciki
Abubuwan da suka dace:
Hanyar sigina > > apoptosis > > apoptosis
Filin bincike > > kumburi / rigakafi
Filin bincike > cututtukan jijiya
A cikin Nazarin Vitro:
Idan aka kwatanta da sarrafawar mai ɗaukar kaya a cikin al'adun HEK, furotin tauraro (0-10 μ M; 3-6 days) yana haɓaka haɓakar tantanin halitta [1].Astramembrangenin (0.3 μM;Minti 5-90) ya haifar da phosphorylation CREB a cikin ƙananan ƙwayoyin cuta na farko, kuma bayyanar jimillar CREB a cikin nau'ikan tantanin halitta ba ta shafi CAG [1].Tauraro membrane furotin (3) μ M;6-48 hours) na iya haɓakawa a cikin siginar siginar vivo a cikin neurons, haɓaka maganganun TERT mRNA, da nuna ƙarar bcl 2 mRNA magana [1].Ƙididdigar iyawar salula [1] layin tantanin halitta: HEK tantanin halitta: 1 μ M ， 3 μ M ， 10 μ M al'ada lokacin: Sakamakon kwanaki 3-6: haɓakar tantanin halitta ya ninka a kwanaki 6.Binciken ɓangarorin Yammacin Yamma [1] layin tantanin halitta: ƙaddamarwar ƙwayoyin neuron: 0.3 μM lokacin al'ada: mintuna 5, mintuna 15, mintuna 30, mintuna 90.Sakamako: CAG ya haifar da kunna CREB a cikin neurons.RT-PCR [1] layin tantanin halitta: ƙaddamarwar ƙwayoyin neuron: 3 μM lokacin al'ada: Sakamakon sa'o'i 6-48: bayyanar TERT da Bcl 2 mRNA sun karu.
Magana:
[1].Ip FC, da dai sauransu.Cycloastragenol shine mai kunnawa telomerase mai ƙarfi a cikin sel neuronal: abubuwan da ke haifar da sarrafa baƙin ciki.Neurosignals.2014; 22 (1): 52-63.
[2].Yu Y, et al.Cycloastragenol: Dan takarar littafi mai ban sha'awa don cututtuka masu alaƙa da shekaru.Exp Ther Med.2018 Satumba; 16 (3): 2175-2182.
[3].Sun C, et al.Cycloastragenol yana ƙaddamar da kunnawa da haɓakawa a cikin concanavalin A-induced linzamin kwamfuta lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Juni; 39 (3): 131-139.
Physicochemical Properties na Cycloastragenol
Yawan yawa:1.2 ± 0.1 g / cm3
Wurin tafasa:617.2 ± 55.0 ° C a 760 mmHg
Wurin narkewa:241.0 zuwa 245.0 ° C
Tsarin kwayoyin halitta:c30h50o
Nauyin kwayoyin halitta:490.715
Wurin walƙiya:327.1 ± 31.5 ° C
Daidaitaccen taro:490.365814
PSA:90.15000
LogP:3.82
Matsin tururi:0.0 ± 4.0 mmHg a 25 ° C
Indexididdigar raɗaɗi:1.582
Bayanin Tsaro na Cycloastragenol
Lambar sufuri na kaya masu haɗari: nonh don duk hanyoyin sufuri
Lambar RTECS;Saukewa: GX8265000
Lambar Kwastam: 2942000000
Cycloastragalol Kwastam
Lambar Kwastam: 2942000000
Littattafan Cycloastragalol
Cycloastragenol shine mai kunnawa telomerase mai ƙarfi a cikin sel neuronal: abubuwan da ke haifar da sarrafa baƙin ciki.
Neurosignals 22 (1), 52-63, (2014)
Cycloastragenol (CAG) shine aglycone na astragaloside IV.An fara gano shi lokacin da ake nunawa Astragalus membranaceus tsantsa don abubuwan da ke aiki tare da abubuwan hana tsufa.Binciken da aka yi a yanzu ya...
Wani labari mai kunnawa telomerase yana hana lalacewar huhu a cikin ƙirar murine na fibrosis na huhu na idiopathic.
PLoS DAYA 8 (3), e58423, (2013)
Bayyanar cututtuka da ke da alaƙa da rashin aiki na telomere, ciki har da AIDS, anemia aplastic da fibrosis na huhu, ya ƙarfafa sha'awar masu kunnawa telomerase.Mun bayar da rahoton gano wani n...
Telomerase na tushen kayan haɓaka kayan aikin antiviral na CD8+ T lymphocytes na ɗan adam.
J. Immunol.181 (10), 7400-6, (2008)
Telomerase reverse yana rubuta DNA telomere zuwa ƙarshen chromosomes na layi kuma yana jinkirta tsufa na salula.Ya bambanta da yawancin ƙwayoyin somatic na al'ada, waɗanda ke nuna kaɗan ko babu aikin telomerase, rigakafi ...
Sunan Ingilishi na Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)
Astramembrangenin
(3β,6α,9β,16β,20R,24R) -20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S) -20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin
