Fraxin;Paviin;Fraxoside;Fraxetol-8-glucoside CAS No.524-30-1
Bayani mai mahimmanci
Lambar CAS:524-30-1 [1]
EINECS Lamba:208-355-5
Tsarin kwayoyin halitta:c16h18o10
Nauyin Kwayoyin Halitta:370.3081
Tsarin Kwayoyin Halitta:(Hoto na 1)
Kaddarori:Hasken rawaya acicular crystal ko flake crystal.
Yawan yawa:1.634g/cm 3
Wurin Tafasa:722.2 ° C a 760 mmHg
Wurin Filashi:267 ° C
Matsin lamba:6.87e-22mmhg a 25 ° C
Bioactivity na Fraxin
Bayani:Ana iya ware Fraxin daga Acer tegmentosum, F. ornus da a.hippocastanum.Yana da glycoside na fraxine [1] kuma yana da antioxidant, anti-mai kumburi da kuma ayyukan metastasis.Fraxin yana nuna ayyukan antioxidant ta hanyar hana adenylate phosphodiesterase cyclic [2].
Manufar:cyclo AMP phosphodiesterase enzyme [2]
A cikin Nazarin Vitro:Fraxin (100 μM) Ba shi da cytotoxicity ga ƙwayoyin Hep G2.Fraxin a cikin abubuwan da ba na cytotoxic ba sun rage haɓakar t-BHP da ke haifar da ROS ta hanyar dogaro da kashi [1].Fraxin (0.5 mm) na iya lalata radicals kyauta a babban taro kuma yana da tasirin cytoprotective akan damuwa na oxyidative mai matsakaici na H2O2 [2].
Nazarin vivo:Fraxin (50 mg / kg, PO) yana toshe CCl4 haɓaka haɓakar ALT da AST.Fraxin (10 da 50 mg / kg, PO) sun rage girman matakan GSSG (1.7 ± 0.3 da 1.5 ± 0.2 nm / g hanta, bi da bi) idan aka kwatanta da matakan GSSG a cikin rukunin da aka kula da CCl4
Magana:.Fraxin (50 mg/kg, po) yana toshe haɓakar CCl4 da aka haifar da ALT da AST.Fraxin (10 da 50 mg / kg, po) yana rage girman matakan GSSG (1.7 ± 0.3 da 1.5 ± 0.2 nM / g hanta, bi da bi) idan aka kwatanta da matakan GSSG na ƙungiyar CCl4-magance [1].
[2].Whang WK, et al.Mahalli na halitta, fraxin da sinadarai da ke da alaƙa da tsarin fraxin suna kare sel daga damuwa na oxidative.Exp Mol Med.2005 Oktoba 31; 37 (5): 436-46.
