Galangin CAS Lamba 548-83-4
Jiki da sinadarai Properties
Laƙabi:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
Sunan Ingilishi:galangin,
Laƙabin Ingilishi:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-phenylchromen-4-daya
Tsarin Kwayoyin Halitta
1. Molar refractive index: 69.55
2. Molar girma (m3 / mol): 171.1
3. Isotonic takamaiman girma (90.2k): 519.4
4. Tashin hankali (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Kimiyyar Lissafi
1. Ƙimar magana don lissafin ma'auni na hydrophobic (xlopp): Babu
2. Yawan masu ba da gudummawar haɗin gwiwar hydrogen: 3
3. Adadin masu karɓar iskar hydrogen: 5
4. Adadin abubuwan da za'a iya jujjuyawan sinadarai: 1
5. Yawan masu yin tauta: 24
6. Topological kwayoyin polarity surface area 87
7. Yawan atom masu nauyi: 20
8. Cajin saman: 0
9. Hadawa: 424
10. Yawan atom na isotopic: 0
11. Ƙayyade adadin abubuwan sitiriyo atom: 0
12. Adadin abubuwan da ba su da tabbas na atomic stereocenters: 0
13. Ƙayyade adadin haɗin gwiwar sitiriyon sinadarai: 0
14. Adadin indeterminate chemical bond stereocenters: 0
15. Yawan raka'o'in haɗin gwiwa: 1
Ayyukan Pharmacological
Galangin na iya canza Salmonella typhimurium TA98 da TA100 kuma yana da tasirin antiviral.
A cikin Nazarin Vitro
Galangin ya hana catabolism na DMBA ta hanyar dogaro da kashi.Galangin kuma ya hana samuwar DMBA-DNA adducts kuma ya hana DMBA haifar da haɓakar ƙwayoyin cuta.A cikin sel marasa lafiya da microsomes waɗanda ke ware daga sel na DMBA da aka kula da su, galangin ya samar da ingantaccen hanawa na dogaro da kashi na ayyukan CYP1A1 wanda aka auna ta aikin ethoxypurine-o-deacetylase.Binciken hana motsin motsi ta hanyar zane-zane biyu ya nuna cewa galangin ya hana ayyukan CYP1A1 ta hanyar da ba ta gasa ba.Galangin yana haifar da haɓaka matakin CYP1A1 mRNA, yana nuna cewa yana iya zama agonist na mai karɓar hydrocarbon aromatic, amma yana hana CYP1A1 mRNA (TCDD) wanda DMBA ko 2,3,5,7-tetrachlorodibenzo-p-dioxin ya jawo.Galangin kuma yana hana DMBA ko TCDD da aka haifar da rubutun ra'ayoyin masu ba da rahoto wanda ya ƙunshi mai tallata CYP1A1 [1].Maganin Galangin ya hana yaduwar kwayar halitta da kuma haifar da autophagy (130) μM) da kuma apoptosis (370 μM) . 3, da (3) ƙara yawan adadin sel tare da vacuoles. P53 magana kuma ya karu. Galangin ya haifar da autophagy an rage shi ta hanyar hana p53 a cikin kwayoyin HepG2, da kuma yawan p53 a cikin kwayoyin Hep3B ya mayar da kashi mafi girma na kwayoyin vacuoles da galangin ya haifar da galangin zuwa matakan al'ada. [2].
Gwajin Kwayoyin Halitta
Kwayoyin (5.0 × 103) an yi musu allura kuma ana bi da su tare da nau'ikan galangin daban-daban a cikin faranti 96 rijiya na lokuta daban-daban.Ta hanyar ƙara 10 μ L na 5 mg / ml MTT bayani don ƙayyade adadin ƙwayoyin rai a kowace rijiya.Bayan shiryawa a 37 ℃ na 4 hours, an narkar da kwayoyin a cikin 100% bayani dauke da 20% SDS da 50% dimethylformamide μL bayani.An ƙididdige ƙimar gani ta amfani da varioskan flash reader spectrophotometer a tsayin gwajin 570 nm da tsayin nuni na 630 nm.
