Isoliquiritin Apioside
Aikace-aikacen Isoliquiritin Apioside
Isoliquiritin apioside, wani ɓangaren da aka keɓe daga glycorrhizae rediyo rhome, ya rage yawan karuwar PMA a cikin ayyukan MMP9 kuma ya hana PMA haifar da MAPK da NF-κ B kunnawa.Isoliquitin apioside yana hana mamayewa da angiogenesis na ƙwayoyin ciwon daji da ƙwayoyin endothelial.
Sunan Isoliquiritin Apioside
Sunan Sinanci:Isoliquiritin Apioside
Sunan Ingilishi:(E) -3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6- (hydroxymethyl) oxan-2-yl] oxyphenyl] -1- (2,4-dihydroxyphenyl) prop-2-en-1-one
Bioactivity na Isoliquiritin Apioside
Bayani:isoliquitin apioside, wani ɓangaren da aka ware daga glycorrhizae rediyo rhome, ya rage yawan karuwar PMA a cikin ayyukan MMP9 kuma ya hana PMA haifar da MAPK da NF-κ B kunnawa.Isoliquitin apioside yana hana mamayewa da angiogenesis na ƙwayoyin ciwon daji da ƙwayoyin endothelial.
Masu alaƙaCdarussa:filin bincike > > ciwon daji
Hanyar sigina > > MAPK / Hanyar siginar ERK > > p38 MAPK
Hanyar sigina > > Metabolism enzyme / protease > > MMP
manufa:MMP9
NF-κB
p38 MAPK
Nazarin in vitro:isorlicin zai iya hana aikin gelation MMP-9 da kyau na sel HT1080 da PMA suka haifar.Isoglycyrrhizin apigenin yana rage haɓakar samar da MMP-9 a cikin ƙwayoyin HT1080 da PMA ke haifar da shi, yana da ikon anti metastasis da anti angiogenesis a cikin ƙwayoyin tumor ƙwayar cuta da ƙwayoyin endothelial, kuma ba shi da cytotoxicity [1].
Magana:[1].Kim A1, et al.Isoliquiritin Apioside Yana hana in vitro Invasiveness da Angiogenesis na Ciwon daji da Kwayoyin Endothelial.Pharmacol na gaba.2018 Dec 10;9:1455.
Abubuwan Physicochemical na Isoliquiritin Apioside
Girma: 1.6 ± 0.1 g / cm3
Matsayin tafasa: 901.0 ± 65.0 ° C a 760 mmHg
Tsarin kwayoyin halitta: c26h30o13
Nauyin Kwayoyin: 550.509
Matsayin walƙiya: 301.9 ± 27.8 ° C
Daidaitaccen taro: 550.168640
PSA: 215.83000
Shafin: 1.96
Matsin lamba: 0.0 ± 0.3 mmHg a 25 ° C
Shafin: 1.709
Sunan Ingilishi na Isoliquiritin Apioside
2-Propen-1-daya,1- (2,4-dihydroxyphenyl) -3-[4-[[2-O-[(2S,3R,4R) -tetrahydro-3,4-dihydroxy-4- (hydroxymethyl). -2-furanyl] -β-D-glucopyranosyl] oxy] phenyl] -, (2E)
3-[(1E) -3- (2,4-Dihydroxyphenyl) -3-oxo-1-propen-1-yl] phenyl 2-O-[(2S,3R,4R) -3,4-dihydroxy-4 (hydroxymethyl) tetrahydro-2-furanyl]-β-D-glucopyranoside.
Neolicuroside
