Salvianolic acid
Manufar
Salvianolic acid C shine mai hana gasa mara gasa na cytochrome p4502c8 (cyp2c8) da kuma mai hanawa na cytochrome P4502J2 (CYP2J2) tare da matsakaicin matsakaici.Kimar sa na cyp2c8 da CYP2J2 sune 4.82 bi da bi μ M da 5.75 μM
Sunan Turanci
(2R) -3- (3,4-Dihydroxyphenyl) -2-({(2E) -3-[2- (3,4-dihydroxyphenyl) - 7-hydroxy-1-benzofuran-4-yl]-2- propanoyl oxy) propanoic acid
Laƙabin Ingilishi
(2R) -3- (3,4-Dihydroxyphenyl) -2-({(2E) -3-[2- (3,4-dihydroxyphenyl) -7-hydroxy-1-benzofuran-4-yl] prop-2 -enoyl}oxy) propanoic acid
(2R) -3- (3,4-Dihydroxyphenyl) -2-({(2E) -3-[2- (3,4-dihydroxyphenyl) -7-hydroxy-1-benzofuran-4-yl]-2- propanoyl oxy) propanoic acid
Benzenepropanoic acid, α-[[(2E) -3-[2- (3,4-dihydroxyphenyl) -7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl] oxy]-3, 4-dihydroxy-, (αR)-
Salvianolic acid
Properties na Physicochemical na Salvianolic Acid C
Girma: 1.6 ± 0.1 g / cm3
Tushen tafasa: 844.2 ± 65.0 ° C a 760 mmHg
Tsarin kwayoyin halitta: C26H20O10
Nauyin Kwayoyin: 492.431
Matsayin walƙiya: 464.4 ± 34.3 ° C
Daidai Mass: 492.105652
PSA: 177.89000
Shafin: 3.12
Matsin lamba: 0.0 ± 3.3 mmHg a 25 ° C
Shafin: 1.752
Bioactivity na Salvianolic Acid C
Bayani:
Salvianolic acid C shine mai hana gasa mara gasa na cytochrome p4502c8 (cyp2c8) da kuma mai hanawa na cytochrome P4502J2 (CYP2J2) tare da matsakaicin matsakaici.Kimar sa na cyp2c8 da CYP2J2 sune 4.82 bi da bi μ M da 5.75 μM.
Rukunin da suka dace:
Hanyar sigina > > enzyme na rayuwa / protease > > cytochrome P450
Filin bincike > > ciwon daji
Kayayyakin halitta > > wasu
Manufar:
CYP2C8: 4.82 μM (Ki)
CYP2J2: 5.75 μM (Ki)
A cikin Nazarin Vitro:
Salvianolic acid C shine matsakaicin gauraye mai hanawa na mai hana cyp2c8 mara gasa da CYP2J2.KIS na cyp2c8 da CYP2J2 sune 4.82 da 5.75 bi da bi μ M[1] .Salvianolic acid C ya rage girman bayyanar iNOS.Salvianolic acid C yana hana LPS haifar da TNF-a, IL-1 β, IL-6 da IL-10 sun yi yawa.Salvianolic acid C yana hana LPS kunna NF-κ B.Salvianolic acid C kuma ya karu da bayyanar Nrf2 da HO-1 a cikin BV2 microglia [2].
A cikin Nazarin Vivo:
Jiyya na Salvianolic acid C (20mg / kg) ya rage jinkirin tserewa.Bugu da ƙari, jiyya na SALC (10 da 20 mg / kg) ya ƙaru da yawan ƙetare dandamali idan aka kwatanta da ƙungiyar ƙirar LPS.Idan aka kwatanta da ƙungiyar ƙirar, tsarin gudanarwa na salvianolic acid C saukar da tsarin kwakwalwar TNF-a, IL-1 β da matakan IL-6.Matakan iNOS da COX-2 a cikin kwakwalwar kwakwalwa da hippocampus na berayen sun kasance mafi girma fiye da waɗanda ke cikin ƙungiyar kulawa, yayin da maganin salvianolic acid C ya rage mahimmancin tsarin cortex da hippocampus.Salvianolic acid C (5, 10 da 20 mg / kg) magani ya karu p-ampk, Nrf2, HO-1 da matakan NQO1 a cikin ratsan cerebral cortex da hippocampus ta hanyar dogaro da kashi [2].
Magana:
[1].Xu MJ, et al.Tasirin hanawa na abubuwan Danshen akan CYP2C8 da CYP2J2.Kamfanin Chem Biol Interact.2018 Yuni 1;289:15-22.
[2].Song J, et al.Kunna siginar Nrf2 ta hanyar salvianolic acid C attenuates NF κ B ta hanyar mayar da martani mai kumburi a cikin vivo da in vitro.Int Immunopharmacol.2018 Oct;63:299-310.
