3-Hydroxy-9,10-dimethoxyptercarpan,Methylnissolin
Ka hoʻohana ʻana i ka Methylnissolin
Hoʻokaʻawale ʻia ʻo Methylnisolin (astrapterocarpan) mai Astragalus membranaceus a hiki ke kāohi i ka hoʻonui ʻana o ka cell i hoʻoulu ʻia e ka platelet-derived growth factor (PDGF) - BB, me kahi IC50 o 10 μ M. Methylnisolin inhibits the phosphorylation of extracellular signal regulated kinase 1 / 2 (ericic 1 / 2 (eric eric). 2) mitogen activated protein (map) kinase i hoʻokomo ʻia e PDGF-BB.Kāohi ʻo Methylnisolin i ka PDGF-BB i hoʻoulu ʻia i ka hoʻonui ʻana o nā ʻiʻo ʻiʻo maʻemaʻe vascular ma ke kāohi ʻana i ka ERK1 / 2 MAP kinase cascade.
Ka inoa o Methylnissolin
inoa Pelekania:
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Alias Pākē: 3-hydroxy-9,10-dimethoxy ʻiliahi ʻulaʻula |ʻulaʻula ʻo Astragalus
ʻiliahi |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy ʻiliahi ʻulaʻula
Ka Hana Ola o Methylnissolin
Hōʻike: methylnisolin (astrapterocarpan) ua hoʻokaʻawale ʻia mai Astragalus membranaceus
a hiki ke pale i ka hoʻonui ʻana o ke kelepona i hoʻoulu ʻia e ka platelet-derived growth factor (PDGF) - BB.
ʻO ka IC50 ka 10 μ M. Methylnisolin ke kāohi i ka phosphorylation o ka hōʻailona extracellular
regulated kinase 1/2 (eric1/2) mitogen activated protein (map) kinase i hoʻokomo ʻia e
PDGF-BB.Kāohi ʻo Methylnisolin i ka PDGF-BB i hoʻoulu ʻia i ka hoʻonui ʻana o ka maʻemaʻe vascular
nā ʻiʻo ʻiʻo ma ke kāohi ʻana i ka ERK1 / 2 MAP kinase cascade.
Nā Māhele e pili ana: kahua noiʻi > > maʻi maʻi puʻuwai
ala hōʻailona > > protein tyrosine kinase > > PDGFR
ala hōʻailona > > MAPK / ERK ala hōʻailona > > ERK
ala hōʻailona > > pūnaewele a me ke ala Wnt > > ERK
Traget:PDGFR:10 μM (IC50)
ERK1
ERK2
Kuhikuhi:[1].Ohkawara S, et al.Hoʻokaʻawale ʻia ʻo Astrapterocarpan mai Astragalus membranaceus i ka hoʻonui ʻana o nā ʻiʻo ʻiʻo maʻemaʻe.Eur J Pharmacol.2005 Nov 21;525(1-3):41-7.
Nā waiwai kino o ka Methylnissolin
Māmā: 1.3 ± 0.1 g / cm3
Puni paila: 428.9 ± 45.0 ° C ma 760 mmHg
Ke Kumu Molekala: c17h16o5
Kaumaha Molekala: 300.306
Kaila Uila: 213.2 ± 28.7 ° C
Nuipa pololei: 300.099762
PSA:57.15000
LogP:2.45
Pumi mahu: 0.0 ± 1.1 mmHg ma 25 ° C
Hōʻike Hōʻikeʻike: 1.612
ʻO Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
ʻO Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., i hoʻokumu ʻia ma Malaki 2012, he ʻoihana ʻenehana kiʻekiʻe e hoʻohui ana i ka R&D, ka hana a me ke kūʻai aku.Hoʻohana nui ʻia ia i ka hana ʻana, hana maʻamau a me ka hoʻomohala ʻana i ke kaʻina hana o nā mea ikaika o nā huahana kūlohelohe, nā mea kuhikuhi lāʻau lapaʻau Kina kuʻuna a me nā haumia lāʻau.Aia ka hui ma China Pharmaceutical City, Taizhou City, Jiangsu Province, me kahi kumu hana 5000 square meter a me kahi kumu 2000 square meter R & D.Hoʻohana nui ia i nā keʻena noiʻi ʻepekema nui, nā kulanui a me nā ʻoihana hana ʻāpana decoction a puni ka ʻāina.
I kēia manawa, ua hoʻomohala mākou ma mua o 1500 mau ʻano o nā reagents kūlohelohe, a hoʻohālikelike ʻia a hoʻohālikelike ʻia ma mua o 300 mau ʻano mea kuhikuhi, hiki ke hoʻokō piha i nā pono nānā i kēlā me kēia lā o nā keʻena noiʻi ʻepekema nui, nā hale hana kulanui a me nā ʻāpana decoction.
Ma muli o ke kumu o ka manaʻoʻiʻo maikaʻi, manaʻolana ka hui e hui pū me kā mākou mea kūʻai.ʻO kā mākou pahuhopu ka lawelawe ʻana i ka hana hou o ka lāʻau lapaʻau Kina.
ʻO ka pāʻoihana maikaʻi o ka hui
1. R & D, hana a kūʻai aku i nā mea hoʻohālikelike kemika o ka lāʻau lapaʻau Kina;
2. Hoʻopilikino ʻia ka lāʻau lapaʻau Kina kuʻuna monomer e like me nā ʻano mea kūʻai aku
3. E noiʻi e pili ana i ke kūlana maikaʻi a me ka hoʻomohala ʻana o ka lāʻau lapaʻau Kina (mea kanu).
4. Hoʻohui ʻenehana, hoʻololi a me ka noiʻi a me ka hoʻomohala lāʻau hou.
