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wehewehe:He mau hana pharmacological ka monoammonium glycyrrhizinate hydrate e like me ka anti-inflammatory, anti allergic, anti gastric ulcer and anti hepatitis.

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Ma ke aʻo ʻana ma Vivo:ʻO ka hoʻonui ʻana o ka māmā w / D ua hoʻemi nui ʻia e ka hoʻohana ʻana i nā kiʻekiʻe a me ka waena o ka mag (10 a me 30 mg / kg).Pretreatment me mag (10 a me 30 mg / kg) hoemi pono TNF- α A me IL-1 β Generation o.ʻO Mag (10,30 mg / kg) i hoʻemi nui i ka NF i hoʻohālikelike ʻia me ka ʻōlelo protein LPS-κ Bp65.I ka hoʻokaʻawale ʻana, ua hoʻohaʻahaʻa nui ʻo LPS i ka I i hoʻohālikelike ʻia me ka pūʻulu mana κ B-α Protein expression, ʻoiai ka mag (10 a me 30 mg / kg) i hoʻonui nui i ka I κ B-α Expression [1].Hoʻohālikelike ʻia me RIF a me INH pūʻulu, haʻahaʻa haʻahaʻa a me kiʻekiʻe-dose MAG lapaʻau nui hoemi ast, alt, TBIL a me TBA pae ma 14 a me 21 lā, e hōʻike ana i ka pale o MAG ma RIF - a me INH -.Hoʻoulu i ka ʻeha ate.MAG lapaau pūʻulu mahuahua akepaʻa GSH pae ma 7, 14 a me 21 lā, a me ka nui hoemi MDA pae ma 14 a me 21 lā ma RIF a me INH mālama 'iole, e hōʻike ana i ka hopena pale o MAG i RIF - a.INH i hoʻokomo ʻia i ka ʻeha o ka ate [2].

Nā hoʻokolohua holoholona:ʻiole [1] i kēia haʻawina, ua hoʻohana ʻia nā ʻiole BALB / c (kāne, 6-8 mau pule, 20-25g).Ua hoʻokaʻawale ʻia nā ʻiole i nā pūʻulu 5: pūʻulu mana, pūʻulu LPS a me LPS + monoammonium glycyrrhizinate (Mag: 3,10 a me 30mg / kg).Loaʻa i kēlā me kēia hui he 8 mau ʻiole.Ua hoʻomaʻamaʻa ʻia nā ʻiole me ka intraperitoneal injection o ka pentobarbital sodium (50 mg / kg).Ua hoʻokomo ʻia nā ʻiole intraperitoneally me ka mag (3, 10 a me 30 mg / kg) ma mua o ka hoʻoulu ʻana i ka ʻeha ʻeha.Ma hope o 1 hola, ua hoʻokomo ʻia ʻo LPS (5 mg / kg) i loko o ka intratracheal no ka hoʻoulu ʻana i ka ʻeha ʻeha.Hāʻawi ʻia nā ʻiole maʻamau i ka PBS [1].Ua hoʻohana nā ʻiole [2] i nā ʻiole Wistar kāne (180-220g).Ua hoʻokaʻawale ʻia nā ʻiole i nā pūʻulu 4: pūʻulu mana, RIF a me INH pūʻulu, hui haʻahaʻa MAG a me ka hui kiʻekiʻe MAG, me nā ʻiole 15 i kēlā me kēia hui.Ua hāʻawi ʻia nā ʻiole ma RIF a me INH pūʻulu RIF (60mg / kg) a me INH (60mg / kg) ma ka gavage hoʻokahi manawa i ka lā;Ua hoʻomaʻamaʻa mua ʻia nā ʻiole ma ka hui MAG me MAG ma ke ʻano o 45 a i ʻole 90 mg / kg, a ua hāʻawi ʻia ʻo RIF (60 mg / kg) a me INH (60 mg / kg) i 3 mau hola ma hope o ka lawelawe ʻana o MAG;Ua mālama ʻia nā ʻiole ma ka hui hoʻomalu me ka paʻakai maʻamau.I mea e loiloi ai i ka hopena ikaika o ka lāʻau lapaʻau, ua pepehi ʻia nā ʻiole i kēlā me kēia hui i 7, 14 a me 21 mau lā ma hope o ka lawelawe ʻana [2].

Kuhikuhi:1].Huang X, et al.Nā hopena anti-inflammatory o Monoammonium Glycyrrhizinate ma luna o Lipopolysaccharide-Induced Acute Lung Injury i loko o nā ʻiole ma o ka hoʻoponopono ʻana i ka Nuclear Factor-Kappa B Signaling Pathway.Evid Based Complement Alternat Med.2015;2015:272474.
[2].Zhou L, et al.Mālama ʻo Monoammonium glycyrrhizinate i ka rifampicin- a me ka isoniazid-induced hepatotoxicity ma o ka hoʻoponopono ʻana i ka ʻōlelo o transporter Mrp2, Ntcp, a me Oatp1a4 i loko o ke ake.Pharm Biol.2016;54(6):931-7.