Astragaloside IV CAS No. 84687-43-4
Hoʻolauna pōkole
ʻŌlelo Pelekane:Astragaloside IV;beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R) -20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy) -9,19-cyclolanostan-6-yl;(3beta,6alpha,9beta,16beta,20R,24S)-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-threo -hexopyranoside
ʻO ke ʻano molekala:C41H68O14
Inoa Kimia:17-[5-(1-Hydroxyl-1-methyl-ethyl)- 2methyl-tetrahydro- furan-2-yl]-4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a] phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D- glucoside
Mp:200~204 ℃
[α]D:-56.6（c,0.13 i DMF）
UV:λmax203 nm
maemae:98%
Puna:legume Astragalus membranaceus, Astragalus pubescens.
ʻO ke kumu hoʻohālike kiʻekiʻe o ka astragaloside IV
Na Waiwai Kinohi
[nānā]:pauda kristal keʻokeʻo
[maemae]:ma luna o 98%, ke ala ʻike: HPLC
[mea kanu kumu]:nā aʻa o Astragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) Aʻa Bungede, Astragalus sieversianus Pall Root o Astragalus spinosus Vahl, ʻāpana lewa o Astragalus spinosus Vahl.
[huahana waiwai]:ʻO Astragalus membranaceus extract ka pauka melemele ʻeleʻele.
[hoʻoholo maʻiʻo]:hoʻoholo e HPLC (Appendix VI D, Volume I, Chinese Pharmacopoeia, 2010 Edition).
Hoʻohana ʻia nā kūlana Chromatographic a me ka hoʻohana ʻana i ka ʻōnaehana} hoʻohana ʻia ʻo octadecyl silane bonded silica gel i mea hoʻopihapiha, hoʻohana ʻia ka wai acetonitrile (32:68) ma ke ʻano paʻa, a hoʻohana ʻia ka mea ʻike hoʻoheheʻe kukui evaporative no ka ʻike.ʻAʻole emi ka helu o nā papa manaʻo ma mua o 4000 e like me ka astragaloside IV peak.
No ka hoʻomākaukau ʻana i ka hāʻina kuhikuhi, e lawe i ka nui kūpono o ka astragaloside IV kuhikuhi, e kaupaona pono iā ia, a hoʻohui i ka methanol e hoʻomākaukau ai i kahi hopena i loaʻa ka 0.5mg no 1ml.
Hoʻomākaukau i ka hoʻonā hoʻāʻo:e lawe ma kahi o 4G o ka pauka mai kēia huahana, e kaupaona pololei, e hoʻokomo i loko o ka Soxhlet extractor, e hoʻohui i ka 40ml o ka methanol, e hoʻomoʻi i ka pō, e hoʻohui i ka nui kūpono o ka methanol, ka wela a me ka reflux no 4 mau hola, e hoʻihoʻi i ka mea hoʻoheheʻe mai ka extract a hoʻopaʻa. a maloʻo, hoʻohui i 10ml o ka wai e hoʻoheheʻe i ke koena, lulu a unuhi me ka n-butanol saturated no 4 mau manawa, 40ml i kēlā me kēia manawa, hui pū i ka wai n-butanol, a holoi piha me ka solution test ammonia no 2 mau manawa, 40ml kēlā me kēia. manawa, e hoolei i ka ammonia solution, e evaporate i ka n-butanol solution, e hoonui i ka wai 5ml e hoopau i ke koena, a hooluolu ia, Ma o D101 macroporous adsorption resin kolamu (i loko anawaena: 37.5px, kolamu kiekie: 300px), elute me 50ml o ka wai. , e hoolei i ka wai wai, elute me 30ml o 40% ethanol, e hoolei i ka eluent, elute me 80ml o 70% ethanol, e ohi i ka eluent, e evaporate ia a maloo, e hoopau i ke koena me ka methanol, e hooili ia i ka 5ml volumetric flask, e hoonui. methanol i ka unahi, lulu maikaʻi, aalaila kii.
ʻano hoʻoholo:e hoʻopaʻa pono i ka 10% o ka hopena kuhikuhi i kēlā me kēia μ l, 20 μ l.Haʻina hoʻāʻo 20 kēlā me kēia μl.E hoʻokomo i loko o ka chromatograph wai, e hoʻoholo iā ia, a e helu me ka hoʻohālikelike logarithm o ke ʻano kumu ʻelua maʻamau maʻamau.
E helu ʻia ma ke ʻano he hua maloʻo, ʻaʻole e emi ka ʻike o ka astragaloside IV (c41h68o14) ma lalo o 0.040%
Hana lāʻau lapaʻau
ʻO nā mea nui o ka Astragalus he polysaccharides a me ka astragaloside.Hoʻokaʻawale ʻia ʻo Astragaloside i astragaloside I, astragaloside II a me astragaloside IV.I waena o lākou, ʻo ka astragaloside IV, astragaloside IV, ka hana olaola maikaʻi loa.ʻO Astragaloside IV ʻaʻole wale ka hopena o Astragalus polysaccharides, akā kekahi mau hopena like ʻole o Astragalus polysaccharides.ʻOi aku ka ikaika o kona ikaika ma mua o ʻelua o ka polysaccharides astragalus maʻamau, a ʻo kāna hopena antiviral he 30 mau manawa ma mua o ka Astragalus polysaccharides.Ma muli o kona haʻahaʻa haʻahaʻa a me ka hopena maikaʻi, ʻike ʻia ʻo ia ʻo "super astragalus polysaccharide".
1.Enhance i ka palekana a me ka maʻi kū'ē.
Hiki iā ia ke hoʻokaʻawale i nā kino ʻē aʻe e hoʻopiʻi ana i ke kino, e hoʻoikaika i ka pale ʻokoʻa, pale a me ka ʻole, a hoʻomaikaʻi i ke kūʻē ʻana o ke kino.Hiki iā ia ke hoʻoikaika i ka hana ʻana o ka antibody, a hoʻonui nui i ka helu o nā antibody e hana ana i nā cell a me ka waiwai hoʻāʻo hemolysis.Hiki i ka Astragaloside IV ke hoʻomaikaʻi nui i ka pae hoʻololi lymphocyte a me ka helu E-rosette o nā moa i hoʻopaʻa ʻia i ka coccidia.He mea hoʻoikaika pono ia o ka ʻōnaehana macrophage monocyte.Hiki i ka Astragaloside IV ke hoʻomaikaʻi i ka oxidation, GSH-Px a me nā hana SOD i loko o nā ʻāpana pale, a me ka hoʻomaikaʻi ʻana i nā hana pale pale a me ka nānā ʻana.
2.Ativiral hopena.
ʻO kāna kumu antiviral: hoʻoulu i ka hana o nā macrophages a me nā pūnae T, hoʻonui i ka nui o nā pūnaewele E-ring, hoʻoulu i nā cytokines, hoʻoikaika i ka induction o interleukin, a hana i ke kino holoholona e hana i ka interferon endogenous, i mea e hoʻokō ai i ke kumu o ka antiviral.Ua hōʻike ʻia nā hopena he 98.33% ka nui o ka pale pale o ka astragaloside IV ma IBD, hiki ke pale a mālama pono i ka IBD, a ʻaʻohe ʻokoʻa koʻikoʻi ke hoʻohālikelike ʻia me ka solution yolk egg immune kiʻekiʻe.Hiki i ka Astragaloside ke hoʻonui i ka hana o nā enzyme antioxidant i loko o ke kino, hoʻemi i ka ʻike o ka LP0, hoʻemi i ka pōʻino o nā ʻano oxygen reactive, a pēlā e hoʻemi ai i ka nui o ka hopena a me ka make o MD.Hiki iā ia ke hoʻomaikaʻi i ka hana haʻahaʻa haʻahaʻa i hoʻokumu ʻia e ka maʻi maʻi, hoʻoikaika i ka hoʻoulu ʻana o nā cell immune, hoʻokuʻu i nā mea endogenous, a pale i ka pepehi ʻana a me ka pale ʻana i nā cell tumor i hana ʻia e ka peroxidation;Hiki i ka Astragaloside a ke pale i ka ulu ʻana o ka maʻi influenza a me ka hana o sialidase.He hopena koʻikoʻi ia i ka hana o ka membrane cell virus influenza a me ka adsorption a me ke komo ʻana o ka maʻi i nā cell sensitive.Ua emi loa ka make a me ka hoomoe ana o ka moa, a ua oi aku ka maikai o ka hoomoe ana o ka hua manu a me ka maikai o ka oho manu ma mua o ka hui hoomalu wale o amantadine, a aole i maopopo ka hopena o Astragalus polysaccharide;Loaʻa i ka Astragaloside IV ka hopena pepehi a me ka pale ʻana i ka maʻi virus.ʻO ka manaʻo o ka hoʻohana ʻana i ka astragaloside IV ma mua o ka loaʻa ʻana o ka maʻi me ka maʻi Nd, no laila ʻoi aku ka maikaʻi o ka hoʻohana ʻana i ka astragaloside IV no ka manawa lōʻihi, Avian myeloblastic leukemia (AMB) 3 mau lā AA broilers hānai ʻia astragaloside IV me ka maʻi. ʻO ka maʻi AMB, hiki ke hoʻemi i ka nui o ka maʻi a me ka make o AMB, e hoʻonui i ka maʻi LPO i loko o nā kino immune e like me ka spleen a me ka thymus, e hoʻonui nui i ka hopena scavenging o ka spleen a me ka thymus a me nā mea pale ʻē aʻe ma nā cell tumor i loaʻa mai i ka myeloid.ʻO ka lua, loaʻa i ka astragaloside IV nā hopena pale a me ka therapeutic i nā maʻi hanu e like me ka laryngotracheitis infectious.Hoʻohana.
3. Anti stress hopena.
Hiki i ka Astragaloside IV ke pale aku i ka hyperplasia adrenal a me ka atrophy thymus i ka wā ʻōlelo aʻoaʻo o ka pane ʻana o ke kaumaha, a pale i nā hoʻololi kūlohelohe i ka wā kūʻē a me ka wā ʻole o ka pane ʻana i ke kaumaha, i mea e pāʻani ai i kahi kuleana anti stress, ʻoi aku ka nui o ka hoʻoponopono ʻelua ala. ka hopena i nā enzymes i ke kaʻina hana o ka metabolism nutrient, a hoʻemi a hoʻopau i ka hopena o ke kaumaha wela i ka hana physiological o ke kino i kekahi ʻano.
4. Ma keʻano he mea hoʻoulu ulu.
Hiki iā ia ke hoʻonui i ka metabolism physiological o nā cell, hoʻoikaika i ke kahe koko, hoʻomaikaʻi i ka metabolism o ke kino holoholona, a pāʻani i ka hana o ka meaʻai a me ka mālama olakino.Hōʻike ka noiʻi hiki iā ia ke hoʻoikaika i ka ulu ʻana o ka bifidobacteria a me ka lactic acid bacteria a loaʻa ka hopena o nā probiotics.
5. Hiki i ka Astragaloside IV ke hoʻomaikaʻi i ka hana cardiopulmonary.
E hoʻoikaika i ka contractility cardiac, pale i ka myocardium a pale aku i ka hāʻule o ka naʻau.Loaʻa iā ia nā hopena o ka pale ʻana i ka ate, anti-inflammatory a me analgesic.Hiki ke hoʻohana ʻia ma ke ʻano he adjuvant therapy no nā maʻi viral a me nā maʻi bacterial.
