Cycloastragenol CAS No. 78574-94-4
Huahana Huahana
[inoa]:cycloastragalus waiʻona
[alias]:triterpenoid cyclic flavonol
[inoa Pelekania]:cycloastragenol
[kumu molekula]:C30H50O5
[kaumaha molekula]:490.71
[CAS No.]:78574-94-4
[ʻano ʻike]:HPLC ≥ 98%
[Hōʻike]:20mg 50mg 100mg 500mg 1g (hiki ke hoʻopili ʻia e like me nā koi o ka mea kūʻai aku)
[nā waiwai]:ʻO kēia huahana he aniani acicular kala ʻole
[hana a hoʻohana]:Hoʻohana ʻia kēia huahana no ka hoʻoholo ʻana i ka ʻike, ʻike, hoʻokolohua lāʻau lapaʻau, kānana hana a me nā hoʻokolohua noiʻi ʻepekema ʻē aʻe.E like me ka hoʻokele cell, intragastric test, internal quality inspection of pharmaceutical factory, etc.Source: Astragalus membranaceus (Fisch.) Bge.Wehe aʻa maloʻo
Keʻano mālama
2-8 ° C, hoʻopaʻa ʻia mai ka mālamalama a mālama ʻia ma kahi haʻahaʻa haʻahaʻa.
Nānā
Pono e mālama ʻia kēia huahana ma kahi haʻahaʻa haʻahaʻa.Inā lōʻihi ka ʻike ʻana i ka ea, e hoʻemi ʻia ka ʻike.
Nā kūlana Chromatographic} kolamu chromatographic: Zorbax rx-c18 (4.6mm) × 150mm), 5 μm ； Māhele kelepona: wai acetonitrile (30:70);Kahe kahe: 1.0ml/min, kolamu wela: 35 ℃, ELSD nā palena: drift tube mahana: 105 ℃, nitrogen kahe ana: 2.70ml/min.
Nā waiwai kikinokino: mānoanoa 1.20
Bioactivity o cycloastragenol
ʻO Cycloastragalol kahi pūhui triterpene saponin, ʻo ia hoʻi ʻo Astragalus membranaceus (Fisch.) ʻO ka hydrolyzate o ka mea hana ma Bunge.Loaʻa iā Astramembrangenin ka palekana o ka waha a he nui nā hopena pharmacological, e komo pū me ka telomerase activation, telomere prolongation, anti-inflammatory and antioxidant properties.Loaʻa iā Astramembrangenin nā waiwai anti-kahiko.Hoʻoulu ʻo CAG i ka hana telomerase i nā keratinocytes hānau hou o ke kanaka a me nā pūnaʻi nerve ʻiole a hoʻoulu i ka hoʻoulu ʻana o CREB.Loaʻa paha i ka Astramembrangenin kahi hopena therapeutic hou i ke kaumaha
Māhele Pili:
Alanui hōʻailona > > apoptosis > > apoptosis
Kahua noiʻi > > ʻeha / ʻaʻa
Kahua noiʻi > > maʻi neʻe
Haʻawina In Vitro:
Ke hoʻohālikelike ʻia me ka mana o ka mea lawe i ka moʻomeheu HEK, hoʻonui ʻia ka ulu ʻana o ka cell membrane star (0-10 μM; 3-6 mau lā) [1].Astramembrangenin（0.3 μ M;5-90 mau minuke) i hoʻokomo i ka phosphorylation CREB i nā neuron cortical mua, a ʻaʻole i hoʻopilikia ʻia ka hōʻike ʻana o ka CREB holoʻokoʻa i nā ʻano cell ʻelua e CAG [1].ʻO ka protein membrane hōkū (3) μ M;6-48 hola) hiki ke hoʻoikaika i ka transduction hōʻailona vivo i nā neurons, hoʻonui i ka hōʻike TERT mRNA, a hōʻike i ka hoʻonui ʻana i ka hōʻike bcl 2 mRNA [1].Ke ho'āʻo ola ola pūnaewele [1] laina kelepona: HEK cell concentration: 1 μ M，3 μ M，10 μ M moʻomeheu manawa: 3-6 lā hopena: ʻelua ka ulu ʻana o ke kelepona ma 6 lā.Ka nānā 'ana i ka Western blot [1] laina kelepona: neuron cell concentration: 0.3 μ M moʻomeheu manawa: 5 minuke, 15 minuke, 30 minuke, 90 minuke.Nā hualoaʻa: CAG i hoʻokomo i ka CREB activation i nā neurons.RT-PCR [1] laina kelepona: neuron cell concentration: 3 μ M moʻomeheu manawa: 6-48 hola hopena: ua hoʻonui ka hōʻike o TERT a me Bcl 2 mRNA.
Kuhikuhi:
[1].Ip FC, et al.ʻO Cycloastragenol kahi mea hoʻoulu telomerase ikaika i nā cell neuronal: nā hopena no ka hoʻokele kaumaha.Nā hōʻailona neuro.2014;22(1):52-63.
[2].Yu Y, et al.Cycloastragenol: He moho hou hoihoi no nā maʻi pili makahiki.Exp Ther Med.2018 Sep;16(3):2175-2182.
[3].ʻO Sun C, et al.Hoʻopili ʻo Cycloastragenol i ka hoʻoulu ʻana a me ka hoʻomāhuahua ʻana i ka concanavalin A-induced mouse lymphocyte pan-activation model.Immunopharmacol Immunotoxicol.2017 Jun;39(3):131-139.
ʻO nā waiwai kino o ka Cycloastragenol
ʻO ka mānoanoa:1.2 ± 0.1 g / knm3
Lae paila:617.2 ± 55.0 ° C ma 760 mmHg
Lae hehee:241.0 a i 245.0 ° C
ʻAno molekala:c30h50o5
kaumaha molekala:490.715
Kuhikuhi uila:327.1 ± 31.5 ° C
Nuipa pololei:490.365814
PSA:90.15000
LogP:3.82
Pumi mahu:0.0 ± 4.0 mmHg ma 25 ° C
Hōʻike hōʻikeʻike:1.582
ʻIkepili Palekana Cycloastragenol
Ke code transport o nā waiwai pōʻino: nonh no nā ʻano o ka halihali
Helu RTECS;GX8265000
Code Dute: 2942000000
Cycloastragalol Customs
Code Dute: 2942000000
Palapala Cycloastragalol
ʻO Cycloastragenol kahi mea hoʻoulu telomerase ikaika i nā cell neuronal: nā hopena no ka hoʻokele kaumaha.
Nā Neurosignals 22 (1), 52-63, (2014)
ʻO Cycloastragenol (CAG) kahi aglycone o ka astragaloside IV.Ua ʻike mua ʻia i ka nānā ʻana i nā ʻāpana Astragalus membranaceus no nā mea hana me nā waiwai antiaging.ʻO ka haʻawina o kēia manawa de...
Hoʻopau ka mea hana telomerase novel i ka pōʻino o ka māmā i loko o kahi hiʻohiʻona murine o ka idiopathic pulmonary fibrosis.
PLoS ONE 8(3) , e58423, (2013)
ʻO ka puka ʻana mai o nā maʻi e pili ana i ka telomere dysfunction, me ka AIDS, aplastic anemia a me ka pulmonary fibrosis, ua hoʻoikaika i ka hoihoi i nā mea hana telomerase.Hōʻike mākou i ka ʻike ʻana o kahi n...
ʻO ka hoʻonui ʻana i ka pharmacologic e pili ana i Telomerase i ka hana antiviral o nā lymphocytes CD8 + T kanaka.
J. Immunol.181(10), 7400-6, (2008)
Hoʻopili ʻo Telomerase reverse i ka telomere DNA ma nā wēlau o nā chromosomes linear a hoʻopaneʻe i ka ʻelemakule kelepona.He ʻokoʻa i ka hapa nui o nā cell somatic maʻamau, e hōʻike ana i ka hana telomerase liʻiliʻi a i ʻole, immun...
ʻŌlelo Pelekane ʻo Cycloastragalol
9,19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24S)-
Astramembrangenin
(3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
19-Cyclolanostane-3,6,16,25-tetrol,20,24-epoxy-,(3β,6α,9β,16β,20R,24R)-
(3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol
Cyclosieversigenin
Cyclogalegigenin
