Nā huahana

wehewehe:ʻO Danshensu kahi mea kūpono o Salvia miltiorrhiza, hiki ke hoʻoikaika i ke ala hōʻailona Nrf2 a pale i ka ʻōnaehana cardiovascular.
Nā Māhele e pili ana: ke ala hōʻailona > > autophagy > > autophagy
Alanui hōʻailona > > NF- κ B ala hōʻailona > > keap1-nrf2
Kahua noiʻi > > maʻi naʻau
Nā Huahana Kūlohelohe > > nā ʻakika benzoic

Haʻawina In Vitro:Ua hoʻemi nui ʻo Danshensu (DSS) i nā kiʻekiʻe o nā enzyme marker (creatine kinase a me lactate dehydrogenase) o ke kahe o ke coronary a me ka nui o ka myocardial infarction.Hiki i kēia ke hoʻoikaika nui i ka hoʻihoʻi ʻana i ka hana naʻau ma hope o ka hōʻeha I / R.Loaʻa i ka DSS ka hana scavenging ROS a hoʻoikaika i ka hana o nā antioxidants endogenous e like me SOD, cat, MDA, GSH-Px a me HO-1 ma o ka hoʻoulu ʻana i ka mea nuclear factor erythrocyte-2 pili 2 (Nrf2) ala hōʻailona i hoʻopili ʻia e Akt a me ERK1.2 ma ke kālailai Western blot [2].

Ma ke aʻo ʻana ma Vivo:ʻAʻole i hoʻololi ka lāʻau lapaʻau me ka nui o Danshensu i ka plasma tHcy i nā ʻiole me ka thcy maʻamau.ʻO ka ʻokoʻa, ua hoʻemi nui ʻo Danshensu i ka tHcy i nā ʻiole me ka tHcy kiʻekiʻe.ʻO nā kiʻekiʻe kiʻekiʻe o ka cysteine ​​a me ka glutathione ma hope o ka mālama ʻana me Danshensu e hōʻike ana i ka hopena o ka hōʻemi ʻana i ka thcy ma o ka hoʻonui ʻana i ka hana o ke ala trans vulcanization [1].

Nā hoʻokolohua holoholona:ua hoʻoheheʻe ʻia nā kinikini a pau i loko o ka paʻakai koe wale nō ka tolcapone i hoʻoheheʻe ʻia i loko o ka paʻakai i loaʻa ka 20% (V / V) peg 200. I ka wā o ka hoʻokolohua, hoʻokē ʻai ʻia nā ʻiole i ka pō a hāʻawi wale ʻia i nā hui like ʻole.Ma hope o ka ether anesthesia, ma kahi o 200 i wehe ʻia mai ka orbital sinus μ L koko, a laila hoʻomaʻemaʻe koke me ka waiʻona a kaomi me ka pulupulu.Ua hōʻiliʻili koke ʻia nā koko koko i loko o nā paipu polypropylene i loaʻa ka sodium heparin a centrifuged ma 5000 g ma 5 ° C no 3 mau minuke.Mālama ʻia nā laʻana plasma i hoʻomākaukau ʻia ma - 20 ℃ a nānā ʻia i loko o 48 mau hola.

Kuhikuhi:[1] YG Cao, et al.Nā hopena maikaʻi o danshensu, he mea ikaika o Salvia miltiorrhiza, ma ka homocysteine ​​metabolism ma o ke ala trans-sulphuration i nā ʻiole.Br J Pharmacol.2009 Iune;157(3): 482–490.

[2].Yu J, et al.Mālama ʻo Danshensu i ka puʻuwai kaʻawale mai ka hōʻeha reperfusion ischemia ma o ka hoʻāla ʻana o ka hōʻailona Akt/ERK1/2/Nrf2.Int J Clin Exp Med.2015 Sep 15;8(9):14793-804.