Fraxin;Paviin;Fraxoside;Fraxetol- 8-glucoside CAS No.524-30-1
ʻIke Pono
Helu CAS:524-30-1 [1]
EINECS Helu.:208-355-5
ʻAno Molekala:c16h18o10
Kaumaha Molekala:370.3081
Hoʻolālā Molekala:(Kiʻi 1)
Nā waiwai:ʻO ke aniani acicular melemele māmā a i ʻole ke aniani flake.
ʻO ka mānoanoa:1.634g/cm3
Lae paila:722.2 ° C ma 760 mmHg
Lae Flash:267 ° C
Pumi mahu:6.87e-22mmhg ma 25 ° C
Bioactivity o Fraxin
wehewehe:Hiki ke hoʻokaʻawale ʻia ka Fraxin mai Acer tegmentosum, F. ornus a me a.hippocastanum.He glycoside ia o ka fraxine [1] a he mau hana antioxidant, anti-inflammatory a me anti metastasis.Hōʻike ʻo Fraxin i ka hana antioxidant ma ke kāohi ʻana i ka cyclic adenylate phosphodiesterase [2].
Pahuhopu:cyclo AMP phosphodiesterase enzyme [2]
Haʻawina In Vitro:ʻO Fraxin (100 μ M) ʻAʻohe ona cytotoxicity i nā pūnaewele Hep G2.ʻO ka Fraxin ma nā ʻano cytotoxic ʻole i hoʻemi nui i ka hana ROS i hoʻokomo ʻia i ka t-BHP ma kahi ʻano i hilinaʻi ʻia [1].Hiki i ka Fraxin (0.5 mm) ke hōʻiliʻili i nā radical manuahi ma ke ʻano kiʻekiʻe a loaʻa ka hopena cytoprotective ma ka H2O2 mediated oxidative stress [2].
ʻO ke aʻo ʻana ma vivo:ʻO Fraxin (50 mg / kg, PO) i pāpā nui i ka CCl4 i hoʻoulu ʻia i ke kiʻekiʻe o ALT a me AST.ʻO Fraxin (10 a me 50 mg / kg, PO) i hoʻemi nui i nā pae GSSG (1.7 ± 0.3 a me 1.5 ± 0.2 nm / g ate, kēlā me kēia) i hoʻohālikelike ʻia me nā pae GSSG i ka hui CCl4 mālama ʻia.
Kuhikuhi:.ʻO Fraxin (50 mg/kg, po) kaohi nui i ka hoʻokiʻekiʻe ʻana o CCl4 o ALT a me AST.ʻO Fraxin (10 a me 50 mg / kg, po) e hoʻemi nui i nā pae GSSG (1.7 ± 0.3 a me 1.5 ± 0.2 nM / g ate, i kēlā me kēia) i hoʻohālikelike ʻia me nā pae GSSG o ka hui CCl4-treated [1].
[2].ʻO Whang WK, et al.ʻO nā pūhui kūlohelohe, fraxin a me nā kemika pili i ka fraxin e pale i nā cell mai ke kaumaha oxidative.Exp Mol Med.2005 ʻOkakopa 31;37(5):436-46.
