Nā huahana

wehewehe:ʻO ka glucoridin he isoflavane mai ka glycorrhiza glabra, hiki ke hoʻopaʻa a hoʻoikaika i ka PPAR γ， ʻO ka waiwai EC50 he 6115 nm.ʻO Glabridin he antioxidant, antibacterial, anti glomerulonephritis, anti diabetes, anti-tumor, anti-inflammatory, anti osteoporosis, pale cardiovascular, pale i nā aʻalolo, scavenge free radical a me nā hana ʻē aʻe.

Māhele pili:kahua noiʻi > > maʻi 'aʻai
Alanui hōʻailona > > pōʻaiapuni pūnaewele / pōʻino DNA > > PPAR
Kahua noiʻi > > ʻeha / ʻaʻa

Haʻawina In Vitro:ʻO ka glabridin e hoʻopaʻa a hoʻoikaika i ka PPAR γ, ʻo EC50 ka 6115 nm [1].ʻO Glabridin (40,80 μ M) Ua kāohi ʻia ka hoʻonui ʻana o nā laina kelepona SCC-9 a me SAS ma kahi ʻano a me ke ʻano o ka manawa ma hope o 24 a me 48 mau hola o ka mālama ʻana [2].ʻO Glabridin (0-80 μ M) Hoʻokomo pū ia i ka apoptosis, e alakaʻi ana i ka hopu ʻana i ka pōʻai cell G1 ma nā laina kelepona SCC-9 a me SAS [2].ʻO Glabridin (0,20,40 a me 80 μ M) i hoʻohana ʻia i ka Caspase-3, - 8 a me - 9 a hoʻonui i ka cleavage PARP, nui ka phosphorylating ERK1 / 2, JNK1 / 2 a me P-38 MAPK ma SCC-9.Nā pūnaewele [2].

Ma ke aʻo ʻana ma Vivo:ʻO glabridin (50 mg / kg, Po hoʻokahi manawa i kēlā me kēia lā) hōʻike i ka hana anti-inflammatory ikaika a hoʻomaikaʻi i nā loli inflammatory i hoʻoulu ʻia e dextran sodium sulfate (DSS) [3]

Kuhikuhi:[1] ʻO Rebhun JF, et al.ʻO ka ʻike ʻana i ka glabridin ma ke ʻano he mea bioactive i loko o ka licorice (Glycyrrhiza glabra L.) extract e hoʻāla ai i ke kanaka peroxisome proliferator-activated receptor gamma (PPAR γ).Fitoterapia.2015 ʻOkakopa;106:55-61.
[2].ʻO Chen CT, et al.Hoʻokomo ʻo Glabridin i ka apoptosis a me ka hopu ʻana i ka pōʻai cell i loko o nā keʻena maʻi maʻi waha ma o ke ala hōʻailona JNK1/2.Toxicol puni.2018 Iune;33(6):679-685.
[3].ʻO El-Ashmawy NE, et al.ʻO ka hoʻohaʻahaʻa ʻana o ka iNOS a me ke kiʻekiʻe o ka cAMP e hoʻopili i ka hopena anti-inflammatory o glabridin i nā ʻiole me ka ulcerative colitis.Inflammopharmacology.2018 Apr;26(2):551-559.