ʻO Isoliquiritin Apioside
Ka hoʻohana ʻana o Isoliquiritin Apioside
ʻO Isoliquiritin apioside, kahi mea i hoʻokaʻawale ʻia mai ka glycorrhizae radio rhome, ua hoʻemi nui ʻia ka PMA i hoʻonui i ka hoʻonui ʻana i ka hana MMP9 a kāohi i ka PMA i hoʻoulu ʻia i ka MAPK a me ka NF-κ B hoʻoulu.Hoʻopili ʻo Isoliquitin apioside i ka hoʻouka ʻana a me ka angiogenesis o nā maʻi maʻi a me nā cell endothelial.
Ka inoa o Isoliquiritin Apioside
Inoa Pākē:ʻO Isoliquiritin Apioside
inoa Pelekania:(E)-3-[4-[(2S,3R,4S,5S,6R)-3-[(2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl] oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Bioactivity o Isoliquiritin Apioside
wehewehe:ʻO isoliquitin apioside, kahi mea i hoʻokaʻawale ʻia mai ka glycorrhizae radio rhome, hoʻemi nui i ka PMA i hoʻonui i ka hoʻonui ʻana i ka hana MMP9 a kāohi i ka PMA i hoʻoulu ʻia i ka MAPK a me ka NF-κ B hoʻoulu.Hoʻopili ʻo Isoliquitin apioside i ka hoʻouka ʻana a me ka angiogenesis o nā maʻi maʻi a me nā cell endothelial.
PiliCnā ʻāpana:kahua noiʻi > > maʻi 'aʻai
Ala hōʻailona > > MAPK / ERK ala hōʻailona > > p38 MAPK
Alanui hōʻailona > > metabolic enzyme / protease > > MMP
Kuhikuhi:MMP9
NF-κB
p38 MAPK
Haʻawina in vitro:Hiki i ka isorlicin ke pale pono i ka hana gelation MMP-9 o ka PMA i hoʻokomo ʻia i nā cell HT1080.Hoʻemi ʻo Isoglycyrrhizin apigenin i ka hoʻonui ʻana o ka hana MMP-9 i nā cell HT1080 i hoʻoiho ʻia e PMA, loaʻa ka mana o ka anti metastasis a me ka anti angiogenesis i loko o nā pūnaewele maʻi maʻi a me nā cell endothelial, a ʻaʻohe cytotoxicity [1].
Kuhikuhi:[1].Kim A1, et al.Hoʻopau ʻo Isoliquiritin Apioside i ka invasiveness in vitro a me ka Angiogenesis o nā maʻi maʻi maʻi a me nā cell endothelial.Front Pharmacol.2018 Dec 10;9:1455.
Nā waiwai kino o ka Isoliquiritin Apioside
Māmā: 1.6 ± 0.1 g / knm3
Ka helu paila: 901.0 ± 65.0 ° C ma 760 mmHg
Kumu molekala: c26h30o13
Kaumaha molekula: 550.509
Kekahi uila: 301.9 ± 27.8 ° C
Nuipa pololei: 550.168640
PSA:215.83000
LogP:1.96
Pumi mahu: 0.0 ± 0.3 mmHg ma 25 ° C
Hōʻike hoʻohālikelike: 1.709
ʻO ka inoa Pelekane o Isoliquiritin Apioside
2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-[4-[[2-O-[(2S,3R,4R)-tetrahydro-3,4-dihydroxy-4-(hydroxymethyl )-2-furanyl]-β-D-glucopyranosyl]oxy]phenyl]-, (2E)-
3-[(1E)-3-(2,4-Dihydroxyphenyl)-3-oxo-1-propen-1-yl]phenyl 2-O-[(2S,3R,4R)-3,4-dihydroxy-4 -(hydroxymethyl)tetrahydro-2-furanyl]-β-D-glucopyranoside
Neolicuroside
