Methylophiopogonanone A;Opogonanone A
ʻO ka hoʻohana ʻana i ka Methylophiopogonanone A
ʻO Methylophiopogonanone A he flavonoids i lawe ʻia mai Ophiopogon japonicas, nona nā hopena antioxidant a me nā anti-inflammatory.
Ka inoa o Methylophiopogonanone A
inoa Pelekania:
(3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one
Nā inoa Pākē:
Ophiopogon methyl flavanone a |methyl Ophiopogon dihydrohomoisoflavone a |methyl Ophiopogon flavanone a
ʻO ka hana olaola o Methylophiopogonanone A
ʻO ka wehewehe: ʻo methylophiopogonanone A he flavonoids i lawe ʻia mai Ophiopogon japonicas, nona ka
antioxidant a me nā hopena anti-inflammatory.
Nā Māhele Pili: ke ala hōʻailona > > apoptosis > > apoptosis
kahua noiʻi > > ʻeha / immunity
In Vitro Study: methyl aspartate a (mo-a; 10 μ Mo (L / L) ua emi loa ka apoptosis a me ka hōʻike Caspase-3, hoʻonui Bcl-2 / Bax ratio a hoʻihoʻi ʻole i ka hana. Methylaspartate a (mo-a) pretreatment
Ua hoʻonui nui ʻia ka hoʻoulu ʻana o ke ala PI3K / Akt / eNOS i nā cell H9c2 ma lalo o H / R, ʻoiai ua hoʻopau ʻia ka hopena pale o ka mo-a i mua o ka PI3K inhibitor wortmannin (100 nmol / L) [1].
Ma Vivo Study: ka hopena pale o ka methylaspartate a (mo-a; 10mg / kg / D, PO) ma ka hana naʻau ma hope o ka hōʻeha ʻana o ka myocardial I / R [1].
Nānā: [1] He F, et al.Hoʻopau ʻo Methylophiopogonanone A i ka ischemia / reperfusion-induced myocardial apoptosis i nā ʻiole ma o ka hoʻoulu ʻana i ke ala hōʻailona PI3K / Akt / eNOS.Acta Pharmacol Sin.2016 Iune;37(6):763-71.
Nā waiwai kino o ka Methylophiopogonanone A
Māmā: 1.4 ± 0.1 g / cm3
Puni paila: 580.1 ± 50.0 ° C ma 760 mmHg
Ke Kumu Molekala: c19h18o6
Kaumaha Molekala: 342.343
Kaila Uila: 212.9 ± 23.6 ° C
Nuipa pololei: 342.110352
PSA:85.22000
LogP:5.16
Pumi mahu: 0.0 ± 1.7 mmHg ma 25 ° C
Hōʻike Hōʻikeʻike: 1.654
ʻŌlelo Pelekane ʻo Methylophiopogonanone A
(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-
N1002
Methylophiopogonanone A
lawelawe ʻo Yongjian
ʻO ka lawelawe maʻamau o nā mea kuhikuhi Kemika o ka lāʻau lapaʻau Kina
ʻO Jiangsu Yongjian Pharmaceutical Technology Co., Ltd. ke hana nui nei i ka noiʻi kumu o nā mea ikaika o ka lāʻau lapaʻau Kina kahiko no nā makahiki he ʻumi.I kēia manawa, ua hana ka hui i ka noiʻi hohonu ma mua o 100 mau ʻano lāʻau lapaʻau Kina maʻamau, a unuhi ʻia nā tausani o nā mea kemika.
Loaʻa i ka hui nā limahana R&D kiʻekiʻe a me nā lako hoʻāʻo a me ka nānā ʻana i ka ʻoihana, a ua lawelawe i nā haneli o nā keʻena noiʻi ʻepekema.Hiki iā ia ke hoʻokō wikiwiki a kūpono i nā pono o nā mea kūʻai
ʻO ka hoʻokaʻawale ʻana i ka lāʻau maʻemaʻe, ka lawelawe hoʻomākaukau a me ka hoʻopaʻa ʻana i ka hale
ʻO nā haumia i loko o nā lāʻau lapaʻau e pili kokoke ana i ka maikaʻi, palekana a me ka paʻa o nā lāʻau.ʻO ka hoʻomākaukau ʻana a me ka hōʻoia ʻana o nā mea haumia i loko o nā lāʻau lapaʻau hiki ke kōkua iā mākou e hoʻomaopopo i ke ʻano o ka haumia a hāʻawi i kumu no ka hoʻomaikaʻi ʻana i ke kaʻina hana.No laila, ʻo ka hoʻomākaukau ʻana a me ka hoʻokaʻawale ʻana i nā mea haumia he mea nui ia i ka noiʻi a me ka hoʻomohala ʻana i ka lāʻau.
Eia nō naʻe, he haʻahaʻa ka ʻike o nā mea haumia i loko o ka lāʻau lapaʻau, ākea ke kumu, a ʻo ke ʻano o ka hoʻolālā e like me ka mea nui.He aha ka ʻenehana hiki ke hoʻohana ʻia e hoʻokaʻawale a hoʻomaʻemaʻe i nā haumia a pau o ka lāʻau lapaʻau i kēlā me kēia a me ka wikiwiki?He aha nā ʻenehana a me nā ʻano hana i hoʻohana ʻia e hōʻoia i ke ʻano o kēia mau haumia?ʻO kēia ka paʻakikī a me ka paʻakikī e kū nei e nā ʻāpana lāʻau lapaʻau he nui, ʻoi aku ka nui o nā ʻoihana lāʻau lapaʻau o ka lāʻau lapaʻau a me ka lāʻau patent Kina.
Ma muli o ia mau pono, ua hoʻokumu ka hui i ka hoʻokaʻawale ʻana i ka haumia lāʻau a me nā lawelawe hoʻomaʻemaʻe.Ke hilinaʻi nei i ka nuclear magnetic resonance, mass spectrometry a me nā mea hana a me nā ʻenehana ʻē aʻe, hiki i ka hui ke ʻike koke i ke ʻano o nā pūhui i hoʻokaʻawale ʻia, i mea e hoʻokō ai i nā pono o nā mea kūʻai aku.
SPF Hoao Holoholona
ʻO ka wahi kūkulu o ka wahi hoʻāʻo holoholona he 1500 mau mika square, me 400 mau mika square o ka wahi hoʻokolohua SPF pae a me 100 mau mika square o ka hale keʻena cell level P2.Alakaʻi ʻia e nā ʻepekema o China Pharmaceutical University, hana ia i kahi hui ʻenehana koʻikoʻi me ka nui o ka poʻe i hoʻi mai.Hāʻawi i nā hiʻohiʻona holoholona kiʻekiʻe, ka hoʻolālā hoʻokolohua, nā papahana holoʻokoʻa a me nā lawelawe ʻē aʻe no ka noiʻi ʻepekema biomedical, ke aʻo ʻana a me ka hoʻomohala ʻenehana.
Lai o ka oihana
1. ʻAi holoholona liʻiliʻi
2. Hoʻohālike maʻi holoholona
3. Ka ho'opuka 'ana i ka papahana kulanui
4. ʻO ka loiloi Pharmacodynamic i vivo
5. ʻO ka loiloi Pharmacokinetic
6. ʻO ka lawelawe hoʻokolohua tumor cell
Ko makou mau ikaika
1. E nānā i nā hoʻokolohua maoli
2. Hoʻohālikelike pono i ke kaʻina hana
3. E kakau inoa i ka aelike huna
4. Keʻena hana ponoʻī me ka ʻole o nā loulou waena
5. Ke hōʻoiaʻiʻo nei ka hui ʻenehana loea i ka maikaʻi hoʻokolohua
Kaiapuni hoʻokolohua SPF, hāʻawi ʻia i ka hānai kanaka, ka nānā ʻana i ka holomua hoʻokolohua manawa maoli
