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Nā huahana

Naringenin Cas No. 480-41-1

ʻO ka wehewehe pōkole:

ʻO ka Naringenin kahi hui kūlohelohe maoli me ka molecular formula c15h12o5.He pauda melemele, hiki ke hoʻoheheʻe ʻia i ka ethanol, ether a me benzene.ʻO ka ʻaʻahu ʻanoʻano mai ka cashew nuts o lacqueraceae.Hoʻohana ʻia ia no ka loiloi qualitative a me ka quantitative o ka lāʻau lapaʻau Kina i loaʻa i ka naringin [1].Ma ke kūlana kalapona 7, hana ia i kahi glycoside me neohesperidin, i kapa ʻia ʻo naringin.He ʻawaʻawa loa.Ke hoʻokumu ʻia nā pūhui dihydrochalcone e ka wehe ʻana o ke apo a me ka hydrogenation ma lalo o nā kūlana alkaline, he mea ʻono ia me ka ʻono a hiki i 2000 mau manawa o ka sucrose.Nui ka Hesperidin i ka ʻili ʻalani.Hoʻokumu ia i ka glycoside me ka rutin ma ke kūlana kalapona 7, i kapa ʻia hesperidin, a hana i ka glycoside me ka rutin ma ke kūlana kalapona 7 β- Neohesperidin ka glycoside o neohesperidin.


Huahana Huahana

Huahana Huahana

Hoʻolauna pōkole

Kaʻina hana:ua hoʻopau nui ʻia e ka ʻili ʻana i ka waiʻona, ka unuhi ʻana, ka chromatography, crystallization a me nā kaʻina hana ʻē aʻe.

Cas No.480-41-1

maʻiʻo kikoʻī:98%

ʻano hoʻāʻo:HPLC

ʻano huahana:keokeo acicular crystal, pauda maikai.

Nā waiwai kino a me kemika:hiki ke hoʻoheheʻe ʻia i ka acetone, ethanol, ether a me benzene, aneane hiki ʻole ke hoʻoheheʻe ʻia i ka wai.He ʻulaʻula ka hopena o ka pauda magnesium hydrochloride, ʻulaʻula ka hopena o ka sodium tetrahydroborate, a ʻaʻole maikaʻi ka hopena o ka molish.

Ola ola:2 makahiki (tentative)

Puna Huahana

Amacardi um occidentale L. kumu a me ka pūpū o ka hua, a pela aku;Prunus yedoensis mats Bud, Mei P. mumesiebet Zucc Bud.

Hana lāʻau lapaʻau

ʻO Naringin ka aglycone o naringin a no ka dihydroflavonoids.Loaʻa iā ia nā hana o ka antibacterial, anti-inflammatory, free radical scavenging, antioxidant, cough and expectorant, blood lipid lowering, anti-cancer, anti-tumor, antispasmodic a me cholagogic, pale a me ka mālama ʻana i nā maʻi o ka ate, inhibition of platelet coagulation, anti atherosclerosis a pēlā aku.Hiki ke hoʻohana nui ʻia i ka lāʻau lapaʻau, ka meaʻai a me nā māla ʻē aʻe.

ʻAiʻiliʻili
Loaʻa iā ia ka hopena antibacterial ikaika ma Staphylococcus aureus, Escherichia coli, dysentery a me typhoid bacillus.He hopena nō hoʻi ʻo Naringin i nā fungi.ʻO ka pīpī ʻana i ka 1000ppm ma ka laiki hiki ke hōʻemi i ka maʻi o Magnaporthe grisea e 40-90%, a ʻaʻohe mea ʻona i nā kānaka a me nā holoholona.

Antiinflammatory
Hoʻokomo ʻia nā ʻiole intraperitoneally me 20mg / kg i kēlā me kēia lā, ka mea i pale nui i ke kaʻina inflammatory i hoʻokumu ʻia e ka hoʻokomo ʻana i ka pōpō hulu hipa.Galati et al.Ua ʻike ʻia ua loaʻa ka hopena anti-inflammatory o kēlā me kēia hui o ka naringin ma o ka hoʻokolohua ʻo ka pepeiao pepeiao ʻiole, a ua hoʻonui ʻia ka hopena anti-inflammatory me ka piʻi ʻana o ka nui.ʻO ka helu inhibition o ka hui kiʻekiʻe he 30.67% me ka ʻokoʻa mānoanoa a me 38% me ka ʻokoʻa kaumaha.[4] Feng Baomin et al.Hoʻokomo ʻia ka papa 3 dermatitis i nā ʻiole e ke ʻano DNFB, a laila hāʻawi i ka naringin ma ka waha no 2 ~ 8 mau lā e nānā i nā helu inhibition o ka manawa koke (IPR), ka hopena hope (LPR) a me ka ultra late phase (VLPR).Hiki iā Naringin ke pale pono i ka edema pepeiao o IPR a me VLPR, a loaʻa kekahi waiwai hoʻomohala i ka anti-inflammatory.

Hoʻoponopono palekana
Mālama ʻo Naringin i kahi kaulike kūpono o ke kaomi oxidative i ka manawa kikoʻī a me nā wahi kikoʻī ma o ka hoʻoponopono ʻana i ke kahe o nā electrons i ka mitochondria.No laila, ʻokoʻa ka hana immunomodulatory o ka naringin mai nā mea hoʻoikaika immune maʻalahi a i ʻole immunosuppressants.ʻO kona hiʻohiʻona hiki iā ia ke hoʻihoʻi i ke kūlana palekana ʻole (ka moku'āina pathological) i kahi kūlana kaulike kūlohelohe maʻamau (ka mokuʻāina physiological), Ma kahi o ka unilaterally hoʻonui a i ʻole ke kāohi ʻana i ka pane kūlohelohe.

Hoʻoponopono hoʻoponopono wahine
Ua like ka hana o Naringin me nā lāʻau anti-inflammatory non steroidal.Hiki iā ia ke hōʻemi i ka synthesis o prostaglandin PGE2 ma ke kāohi ʻana i ka cyclooxygenase Cox, a pāʻani i ka hana o ka antipyretic, analgesic a me ka hoʻohaʻahaʻa ʻana i ka mumū.
Ma muli o ka estrogen e like me ka hopena o ka naringin, hiki ke hoʻohana ʻia ka naringin no ka lāʻau hoʻololi estrogen i nā wahine postmenopausal e pale aku i nā hopena koʻikoʻi ma muli o ka hoʻohana ʻana i ka estrogen lōʻihi.

Nā hopena i ka momona
Loaʻa ka hopena therapeutic o Naringin i ka hyperlipidemia a me ka momona.
Hiki i ka Naringin ke hoʻomaikaʻi maikaʻi i ke kiʻekiʻe o ka cholesterol plasma kiʻekiʻe, ka TG (triglyceride) a me ka momona momona manuahi i nā ʻiole momona.Ua ʻike ʻia ua hiki i ka naringin ke hoʻoponopono i ka monocyte peroxisome proliferator i hoʻāla ʻia i ka ʻiole kiʻekiʻe momona kiʻekiʻe δ, Hoʻemi i ka pae koko lipid.
Ma o nā hoʻokolohua lapaʻau, ua ʻike ʻia ua lawe nā mea maʻi me ka hypercholesterolemia i hoʻokahi capsule i loaʻa ka 400mg naringin i kēlā me kēia lā no 8 pule.Ua emi iho ka nui o ka TC a me ka LDL cholesterol i loko o ka plasma, akā, ʻaʻole i loli nui ka nui o ka cholesterol TG a me HDL.
I ka hopena, hiki i ka naringin ke hoʻomaikaʻi i ka hyperlipidemia, i hōʻoia maikaʻi ʻia i nā hoʻokolohua holoholona a me nā hoʻokolohua lapaʻau.

Hoʻopau i nā radical manuahi a me ka antioxidant
ʻO ka DPPH (dibenzo bitter acyl radical) he mea paʻa kūʻokoʻa.Hiki ke loiloi ʻia kona hiki ke ʻoki i nā radical manuahi e kāna 517 nm absorbance attenuation.[6] Ua aʻo ʻo Kroyer i ka hopena antioxidant o ka naringin ma o nā hoʻokolohua a hōʻoia ʻia he hopena antioxidant ka naringin.[7] ʻO Zhang Haide et al.Ua ho'āʻo i ke kaʻina hana o ka lipid peroxidation o LDL e ka colorimetry a me ka hiki ke pale i ka hoʻololi oxidative o LDL.ʻO Naringin ka nui o ka chelates Cu2 + ma o kāna mau hui 3-hydroxyl a me 4-carbonyl, a i ʻole e hāʻawi i ka proton a me ka hoʻokaʻawale radical manuahi, a i ʻole pale i ka LDL mai ka lipid peroxidation ma o ka hoʻonā ʻana iho.Ua ʻike ʻo Zhang Haide a me nā poʻe ʻē aʻe he hopena maikaʻi ka naringin ma ke ʻano DPPH.Hiki ke ʻike ʻia ka hopena o ka hoʻoheheʻe ʻana o ka radical manuahi e ka hydrogen oxidation o ka naringin ponoʻī.[8] Peng Shuhui et al.Ua ho'ohana 'ia ke kŘkohu ho'okolohua o ka riboflavin māmā (IR) - nitrotetrazolium chloride (NBT) - spectrophotometry e hō'oia i ka naringin i ka hopena scavenging ma luna o reactive oxygen ano O2 -, i oi aku ka ikaika ma mua o ka ascorbic acid i ka mana maikai.Ua hōʻike ʻia nā hopena o nā hoʻokolohua holoholona i ka naringin i ka hopena inhibitory ikaika i ka lipid peroxidation i ka lolo ʻiole, ka puʻuwai a me ka ate, a hiki ke hoʻonui nui i ka hana o ka superoxide dismutase (SOD) i ke koko holoʻokoʻa o ka ʻiole.

Palekana naʻau
Hiki i ka Naringin a me ka naringin ke hoʻonui i nā hana o ka acetaldehyde reductase (ADH) a me ka acetaldehyde dehydrogenase (ALDH), e hōʻemi i nā ʻike o nā triglycerides i loko o ka ate a me ka nui o ka cholesterol i loko o ke koko a me ka ate, hoʻonui i ka ʻike o ka lipoprotein cholesterol kiʻekiʻe (HDLC), hoʻonui i ka ratio. o HDLC i ka nui o ka cholesterol, a e hoemi i ka atherogenic index i ka manawa like, Naringin hiki ke paipai i ka lawe ana o ka cholesterol mai ka plasma i ka ate, bile huna a me ka excretion, a keakea i ka hoololi ana o HDL i VLDL a LDL.No laila, hiki i ka naringin ke hoʻemi i ka hopena o ka arteriosclerosis a me ka maʻi naʻau coronary.Hiki i ka Naringin ke ho'ēmi i ka nui o ka cholesterol i loko o ka plasma a hoʻoikaika i kona metabolism.

Ka hopena hypolipidemic
ʻO Zhang Haide et al.Ua ho'āʻo ʻia ka serum cholesterol (TC), low density lipoprotein cholesterol (LDL-C), plasma high density lipoprotein cholesterol (HDL-C), triglyceride (TG) a me nā mea ʻiole ʻē aʻe ma hope o ka hoʻokele intravenous ma o nā hoʻokolohua holoholona. serum TC, TG a me LDL-C a hoʻonui i ka serum HDL-C i kekahi maʻi, e hōʻike ana i ka hopena o ka naringin i ka hoʻemi ʻana i ka lipid koko i nā ʻiole.[

Hana Antitumor
Hiki i ka Naringin ke hoʻoponopono i ka hana immune a keʻakeʻa i ka ulu ʻana o ka tumor.He hana ko Naringin ma ka leukemia iole L1210 a me ka sarcoma.Ua hōʻike ʻia nā hopena ua hoʻonui ʻia ka nui o nā ʻiole thymus / kino kaumaha ma hope o ka lawelawe waha o ka naringin, e hōʻike ana e hiki i ka naringin ke hoʻonui i ka hana pale o ke kino.Hiki iā Naringin ke hoʻoponopono i ke kiʻekiʻe o nā lymphocytes T, hoʻoponopono i ka hemahema o ka pale ʻana ma muli o ka maʻi a i ʻole radiotherapy a me ka chemotherapy, a hoʻomaikaʻi i ka hopena pepehi ʻana o nā maʻi kanesa.Ua hōʻike ʻia e hiki i ka naringin ke hoʻonui i ke kaumaha o thymus i ka ascites cancer bearing mice, e manaʻo ana e hiki ke hoʻonui i ka hana immune a hoʻoneʻe i kona hiki ke kū'ē i ka maʻi kanesa.Ua ʻike ʻia ua loaʻa ka hopena o ka ʻili pomelo i ka sarcoma S180, a ʻo 29.7%.

ʻO ka antispasmodic a me ka cholagogic
He hopena koʻikoʻi ia i nā flavonoids.He hopena ikaika nō hoʻi ʻo Naringin i ka hoʻonui ʻana i ka huna bile o nā holoholona hoʻokolohua.

ʻO ka hopena antitussive a me ka expectorant
Ke hoʻohana nei i ka phenol ʻulaʻula ma ke ʻano he hōʻailona o ka hopena hoʻopau ʻana i ka maʻi, hōʻike ka hoʻokolohua ʻo ka naringin he ikaika ikaika a me ka hopena expectorant.

Hoʻohana lāʻau lapaʻau
Hoʻohana ʻia ia e mālama i ka maʻi bacterial, sedative a me nā lāʻau anticancer.
ʻO ke ʻano o ka hoʻohana ʻana: suppository, lotion, injection, tablet, capsule, etc.


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