Neohesperidin
Hoʻohana i ka Synephrine Hydrochloride
ʻO Neohesperidin kahi ʻano o ka pūhui flavonoid e kū nui ana i nā mea kanu Cucurbitaceae a loaʻa nā hopena antioxidant a me nā anti-inflammatory./h2>
Ka inoa o Neohesperidin
Ka inoa Pelekane: neohesperidin
Pākē Alias: neohesperidin |neohesperidin
Bioactivity o Neohesperidin
ʻO ka wehewehe: ʻo ka neohesperidin kahi pūhui flavonoid i loaʻa i Cucurbitaceae, nona nā hopena antioxidant a me nā anti-inflammatory.
Nā ʻāpana pili: ala hōʻailona > > ʻē aʻe > > ʻē aʻe
kahua noiʻi > > ʻeha / immunity
Nā huahana kūlohelohe > > flavonoids
Haʻawina In Vitro:
Hoʻokomo ka hesperidin hou i ka apoptosis i ka maʻi maʻi umauma kanaka MDA-MB-231.ʻO nā waiwai IC50 o neohesperidin ma 24 a me 48 hola he 47.4 ± 2.6, kēlā me kēia μ M a me 32.5 ± 1.8 μ M. Ua hoʻonui nuiʻia ka'ōlelo o ka p53 a me Bax i nā pūnaewele mālamaʻia neohesperidin, aʻo ka'ōlelo o Bcl-2 i lalo. hooponopono [1].Ua hōʻike ʻo Neohesperidin i ka hana antioxidant ma ka DPPH radical scavenging test (IC50 = 22.31 μg/mL) [2].
In Vivo Study: neohesperidin (50mg / kg) nui inhibited 55.0% HCl / ethanol induce gastric hōʻeha.I ka pylorus ligated iole, neohesperidin (50 mg / kg) hoemi loa 'ā'ī huna huna a me gastric acid puka a hoʻonui pH [1].ʻO ka mālama ʻana iā Neohesperidin i hoʻemi nui i ka hoʻokē ʻai koko glucose, koko glucose a me ka glycosylated serum protein (GSP) i nā ʻiole.Ua hoʻonui nui ia i ka hoʻomanawanui glucose waha a me ka naʻau o ka insulin, a hoʻemi i ka pale ʻana o ka insulin i nā ʻiole maʻi maʻi.ʻO Neohesperidin ka mea i hoʻemi nui i ka triglycerides serum, ka nui o ka cholesterol, ka pae leptin a me ka helu ate ma nā ʻiole [3].
Hoʻāʻo holoholona: nā ʻiole: Hoʻokē ʻai nā ʻiole āpau i 6 mau hola ma mua o ka hoʻāʻo ʻana, a laila hānai ʻia me ka wai a i ʻole neohesperidin e ka hānai koi.No ka OGTT a me ITT, ua hoʻokomo ʻia nā ʻiole intraperitoneally me 2G / kg BW glucose a i ʻole 1iu / kg BW insulin, kēlā me kēia.Ua hōʻiliʻili ʻia nā laʻana koko mai ka caudal vein e ana i ke kiʻekiʻe o ka glucose koko basal (0 mau minuke) ma mua o ka hoʻokomo ʻana i ka glucose a i ʻole ka insulin.Ua ana ʻia nā pae glucose koko hou ma 30, 60, 90 a me 120 mau minuke [3].
Kuhikuhi:[1].Lee JH, et al.ʻO nā hopena pale o ka neohesperidin a me ka poncirin i hoʻokaʻawale ʻia mai nā hua o Poncirus trifoliata i ka maʻi ʻōpū.ʻO Phytother Res.2009 Dek;23(12):1748-53.
[2].Xu F, et al.Hoʻokomo ʻo Neohesperidin i ka apoptosis cellular i loko o ka umauma adenocarcinoma MDA-MB-231 mau mea ma o ka hoʻoulu ʻana i ke ala hōʻailona Bcl-2 / Bax.Nat Prod Commun.2012 Nov;7(11):1475-8.
[3].Jia S, et al.Nā hopena hypoglycemic a me hypolipidemic o neohesperidin i loaʻa mai ka Citrus aurantium L. i ka maʻi maʻi KK-A (y) mice.Hana Meaʻai.2015 Mar;6(3):878-86.
Na Pono Kinohi O Neohesperidin
Māmā: 1.7 ± 0.1 g / cm3
Puni paila: 933.7 ± 65.0 ° C ma 760 mmHg
Lae hehee: 239-243 º C
Ke Kumu Molekala: C28H34O15
Kaumaha Molekala: 610.561
Kaila Uila: 306.7 ± 27.8 ° C
Nuipa pololei: 610.189758
PSA:234.29000
LogP:2.44
Nānā: 0.0 ± 0.3 mmHg ma 25 ° C
Pumi mahu: 0.0 ± 0.3 mmHg ma 25 ° C
Hōʻike Hōʻikeʻike: 1.695
Kūlana mālama: 2-8 ° C
ʻIke Hou Hesperidin Palekana
Nā lako pale pilikino: nā pale maka;Nā mīkina lima;ʻano N95 (US);ʻano P1 (EN143) kānana respirator
ʻŌlelo Palekana (Europa): s22-s24 / 25
Ke code transport o nā waiwai pōʻino: nonh no nā ʻano o ka halihali
Wgk Kelemānia: 3
RTECS Helu: dj2981400
Palapala Neohesperidin
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BMC Plant Biol.15 , 89, (2015)
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Chin.ʻO Med.10, 14, (2015)
Ua hōʻike ʻia ʻo Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) i nā hopena anti-tumor me nā ʻano kumu kumu ʻike ʻole.Ke manaʻo nei kēia noiʻi e loiloi i ka hiki ke hana anti-metastatic ...
ʻO Hesperidin, nobiletin, a me tangeretin ke kuleana no ka hiki ke anti-neuroinflammatory o ka ʻili tangerine (Citri reticulatae pericarpium).
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ʻO ka pale ʻana i ka microglial activation-mediated neuroinflammation ua lilo ia i mea hoʻoholo no ka hoʻomohala ʻana i nā meaʻai hana e mālama ai i nā maʻi neurodegenerative.ʻO ka ʻili Tangerine (Citri reticulata...
English Alias Of Neohesperidin
HESPRETIN-7-NEOHESPERIDOSIDE
Hesperetin7-neohesperidoside
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L- mannopyranosyl)-β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
MFCD00017357
Hesperetin-7-O-neohesperidoside
EINECS 236-216-9
(S)-4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)-
Hesperetin 7-O-neohesperidoside
