Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Name
inoa Pelekania:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Bioactivity o Ophiopogon Japonicus Saponin D
wehewehe:ʻO Ophiopogon D he mea laha ʻole C29 steroidal glycoside i hoʻokaʻawale ʻia mai ka ʻuala o Ophiopogon japonicus.Ophiopogonin D he CYP2J3 inducer e hoʻonui ana i ka CYP2J2 / eets a me ka PPAR i loko o ke kanaka umbilical vein endothelial cell (HUVECs) α ʻO ka'ōlelo o Ang II i kāohi nui i ka Ang II i hoʻokomo i ka NF- κ B nuclear translocation, I κ B α Down regulation, intracellular Ca2 + ka nui a me ka hoʻoulu ʻana o nā cytokines proinflammatory.Ua hoʻohana ʻia ʻo Ophiopogonin D e mālama i ka mumū a me nā maʻi cardiovascular no nā kaukani mau makahiki.
Māhele Pili
Alanui hōʻailona > > ka lawe transmembrane > > kaila calcium
Kahua noiʻi > > maʻi naʻau
Alanui hōʻailona > > pōʻaiapuni pūnaewele / pōʻino DNA > > PPAR
Kahua noiʻi > > ʻeha / ʻaʻa
Kuhikuhi
PPARα
NF-κB
Ca2+
Nā palapala kuhikuhi:[1].Wang L , et al.Homo-aro-cholestane, furostane a me spirostane saponins mai nā ʻōpala o Ophiopogonjaponicus.Phytochemistry.2017 Apr;136:125-132.
[2].Huang X, et al.ʻO ka Ophiopogonin D a me nā EET e hoʻomaikaʻi i nā pane inflammatory Ang II ma o ka hoʻouluʻana i ka PPARα ma HUVECs.Biochem Biophys Res Commun.2017 Aug 19;490(2):123-133.
ʻO ka inoa Pelekane o Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-5-hydroxy-2-(((4R,5'R,6R,6aR,6bS,8aS) ,8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-(((2S,3R,4S,5R) -3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
ʻO Ophiopogonin D
ʻO Deacetylophiopogonin C
