ʻO ka waika Salvianolic C
Ke kumu
ʻO ka Salvianolic acid C he mea hoʻokūkū hoʻokūkū ʻole o ka cytochrome p4502c8 (cyp2c8) a me kahi mea hoʻopaneʻe hui pū ʻia o ka cytochrome P4502J2 (CYP2J2) me ka ikaika waena.ʻO kona mau helu Ki no cyp2c8 a me CYP2J2 he 4.82 μ M a me 5.75 μ M.
Inoa Pelekania
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)- 7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy)ʻakika propanoic
ʻŌlelo Pelekane
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy)ʻakika propanoic
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy)ʻakika propanoic
Benzenepropanoic acid, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3, 4-dihydroxy-, (αR)-
ʻO ka waika Salvianolic C
Nā waiwai kino o ka ʻakika Salvianolic C
Māmā: 1.6 ± 0.1 g / knm3
Puni paila: 844.2 ± 65.0 ° C ma 760 mmHg
Ke Kumu Molekala: C26H20O10
Kaumaha Molekala: 492.431
Kaila uila: 464.4 ± 34.3 ° C
Nuipa pololei: 492.105652
PSA:177.89000
LogP: 3.12
Pumi mahu: 0.0 ± 3.3 mmHg ma 25 ° C
Hōʻike hoʻohālikelike: 1.752
Bioactivity o Salvianolic Acid C
wehewehe:
ʻO ka Salvianolic acid C he mea hoʻokūkū hoʻokūkū ʻole o ka cytochrome p4502c8 (cyp2c8) a me kahi mea hoʻopaneʻe hui pū ʻia o ka cytochrome P4502J2 (CYP2J2) me ka ikaika waena.ʻO kāna mau helu Ki no cyp2c8 a me CYP2J2 he 4.82 μM a me 5.75 μM.
Nā waeʻano pili:
Alanui hōʻailona > > metabolic enzyme / protease > > cytochrome P450
Kahua noiʻi > > maʻi 'aʻai
Nā Huahana Kūlohelohe > > nā mea ʻē aʻe
Pahuhopu:
CYP2C8:4.82 μM (Ki)
CYP2J2:5.75 μM (Ki)
Haʻawina In Vitro:
ʻO ka Salvianolic acid C he mea hoʻopaneʻe hui pū ʻia o ka mea hoʻokūkū ʻole cyp2c8 a me CYP2J2.ʻO ka KIS o cyp2c8 a me CYP2J2 he 4.82 a me 5.75 pakahi μ M[1] 。 1 a me 5 μ M salvianolic acid C (SALC) hiki ke kaohi nui i ka LPS i hoʻokomo ʻole ʻia.Ua hoʻemi nui ka Salvianolic acid C i ka hōʻike o iNOS.ʻO ka Salvianolic acid C ke kāohi i ka LPS i hoʻokomo ʻia i ka TNF-α, IL-1 β, IL-6 a me IL-10 i hana nui ʻia.ʻO ka Salvianolic acid C ke kāohi i ka LPS i hoʻoulu ʻia i ka NF-κ B.Ua hoʻonui pū ka Salvianolic acid C i ka hōʻike o Nrf2 a me HO-1 ma BV2 microglia [2].
Ma nā haʻawina Vivo:
ʻO ka lāʻau Salvianolic acid C (20mg / kg) i hōʻemi nui i ka latency pakele.Eia kekahi, ua hoʻonui nui ka mālama SALC (10 a me 20 mg / kg) i ka nui o nā crossings platform i hoʻohālikelike ʻia me ka hui hoʻohālike LPS.Hoʻohālikelike ʻia me ka pūʻulu hoʻohālike, hoʻokele ʻōnaehana o ka salvianolic acid C i lalo i hoʻoponopono ʻia ka lolo TNF-α， IL-1 β A me IL-6 pae.ʻOi aku ka kiʻekiʻe o nā kiʻekiʻe o iNOS a me COX-2 i loko o ka cerebral cortex a me ka hippocampus o nā ʻiole ma mua o ka poʻe i loko o ka pūʻulu hoʻomalu, ʻoiai ka mālama ʻana i ka salvianolic acid C i hoʻoponopono nui i ka cortex a me ka hippocampus.Ua hoʻonui ka lāʻau Salvianolic acid C (5, 10 a me 20 mg / kg) i nā pae p-ampk, Nrf2, HO-1 a me NQO1 i nā kiʻekiʻe o ka cerebral cortex a me ka hippocampus ma ke ʻano o ka hopena.
Kuhikuhi:
[1].Xu MJ, et al.Nā hopena pale o nā mea Danshen ma CYP2C8 a me CYP2J2.Pāʻani ʻo Chem Biol.2018 Iune 1;289:15-22.
[2].Mele J, et al.ʻO ka hoʻouluʻana o ka Nrf2 hōʻailona e ka salvianolic acid C attenuates NF κ B i hoʻopiliʻia i ka pane inflammatory ma vivo a me in vitro.Int Immunopharmacol.2018 ʻOkakopa;63:299-310.
