Hesperidin;Cirantin；Hesperidin；Hesperidoside
Product Specification
Common Name: hesperidin
CAS No.: 520-26-3
Density: 1.7 ± 0.1 g / cm3
Molecular Formula: C28H34O15
English Name: hesperidin
Molecular Weight: 610.561
Boiling Point: 930.1 ± 65.0 ° C at 760 mmHg
Melting Point: 250-255 ° C (Dec.) (lit.)
MSDS: Chinese version, American version, flash point: 305.5 ± 27.8 ° C
Bioactivity of hesperidin
Description:
Hesperidin (HP) is a biological flavonoid with biological and pharmacological properties. It is an effective antioxidant, anti-inflammatory, anticancer, lipid-lowering and antihypertensive agent。
Relevant categories:
Signaling pathway > > autophagy > > autophagy
Natural Products > > flavonoids
Research field > > cancer
Reference：
1]. Asli Cetin, Ali Otlu et al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3): 486-493.
[2]. Gesivaldo Santos, Bruno Andrade et al. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci, 2016, 8: 97.
[3]. Jin Zhang, Jing Gao et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer, 2015, 15: 682.
[4]. Cetin A, Otlu A, ea al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachlorideadministration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3):486-93.
Physicochemical Properties Of Hesperidin
Density: 1.7 ± 0.1 g / cm3
Boiling Point: 930.1 ± 65.0 ° C at 760 mmHg
Molecular Formula: c28h34o15
Molecular Weight: 610.561
Flash Point: 305.5 ± 27.8 ° C
Exact Mass: 610.189758
PSA:234.29000
LogP:1.78
Appearance: light brown powder
Steam Pressure: 0.0 ± 0.3 mmHg at 25 ° C
Refractive Index: 1.695
Storage Conditions: glass bottles are sealed and packed, or plastic bags are covered with kraft paper bags. Store in a cool and dry place
Stability: light yellow crystalline powder. Melting point: 258-262 ℃ (softened at 252 ℃). Easily soluble in pyridine and sodium hydroxide solution, soluble in dimethylformamide, slightly soluble in methanol and hot glacial acetic acid, very slightly soluble in ether, acetone, chloroform and benzene. 1g of this product is dissolved in 50L water. Odorless and tasteless.
Toxicity and ecology of hesperidin
Toxicological data of hesperidin:
Acute toxicity: mouse intraperitoneal LC50: 1gm / kg, no detailed description except lethal dose.
Ecological data of hesperidin:
This substance may be harmful to the environment, so special attention should be paid to the water body.
Hesperidin Safety Information
Personal Protective equipment: eyeshields; Gloves; type N95 (US); type P1 (EN143) respirator filter.
Hazard Code (Europe): Xi: iritant;
Safety Statement (Europe): s22-s24 / 25
Risk Statement (Europe): R22
Transport Code Of Dangerous Goods: nonh for all modes of transport
Wgk Germany: 3
RTECS No.: mk6650000
Literature: Yamada, Mika; Tanabe, Fujimi; Arai, Norie; Mitsuzumi, Hitoshi; Miwa, Yoshikatsu; Kubota, Michio; Chaen, Hiroto; Kibata, Masayoshi Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 6 p. 1386 - 1394
Hesperidin literature
Bio-refinery of orange peels waste: a new concept based on integrated green and solvent free extraction processes using ultrasound and microwave techniques to obtain essential oil, polyphenols and pectin.
Ultrason. Sonochem. 24 , 72-9, (2015)
In this study, extraction of essential oil, polyphenols and pectin from orange peel has been optimized using microwave and ultrasound technology without adding any solvent but only "in situ" water whi...
Effects of pectinase clarification treatment on phenolic compounds of pummelo (Citrus grandis l. Osbeck) fruit juice.
J.Food Sci. Technol. 52 , 5057-65, (2015) k.
The purpose of this study is to investigate the changes occured on phenolic compounds between two Malaysian varieties of pummelo fruit juice: Ledang (PO55) and Tambun (PO52) post-enzymatic clarificati...
Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain.
Food Chem. Toxicol. 74 , 51-9, (2014)
D-galactose, a reducing sugar, induces oxidative stress resulting in alteration in mitochondrial dynamics and apoptosis of neurons. Curcumin and hesperidin are antioxidants possessing multimodal funct...
Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by D-galactose in rat brain.
Food Chem. Toxicol. 74 , 51-9, (2014)
D-galactose, a reducing sugar, induces oxidative stress resulting in alteration in mitochondrial dynamics and apoptosis of neurons. Curcumin and hesperidin are antioxidants possessing multimodal funct...
English Alias of Hesperidin
usafcf-3
Hesperetin 7-rhamnoglucoside,Hesperitin-7-rutinoside
VITAMIN P
Hespeidin
Cirantin
MFCD00075663
Hesperetin7-rutinoside
Cirontin
Hesperidoside
Hesperetin7-rhamnoglucoside
Hesperidin
EINECS 208-288-1
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