3-Hydroxy-9,10-dimethoxyptercarpan, Methylnissolin
Kev siv Methylnissolin
Methylnisolin (astrapterocarpan) yog cais los ntawm Astragalus membranaceus thiab tuaj yeem cuam tshuam cov cell proliferation vim platelet-derived growth factor (PDGF) - BB, nrog IC50 ntawm 10 μ M. Methylnisolin inhibits phosphorylation ntawm extracellular teeb liab tswj 2 / 1 kinase (1 2) mitogen activated protein (daim ntawv qhia) kinase induced los ntawm PDGF-BB.Methylnisolin inhibits PDGF-BB induced proliferation ntawm vascular du leeg hlwb los ntawm inhibiting ERK1 / 2 MAP kinase cascade.
Lub npe Methylnissolin
Lub npe Askiv:
(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Suav Alias: 3-hydroxy-9,10-dimethoxy liab sandalwood |Astragalus liab
sandalwood |(6aR, 11ar) - 3-hydroxy-9,10-dimethoxy liab sandalwood
Biological Activity ntawm Methylnissolin
Nqe lus piav qhia: methylnisolin (astrapterocarpan) yog cais los ntawm Astragalus membranaceus
thiab tuaj yeem cuam tshuam cov cell proliferation induced los ntawm platelet-derived growth factor (PDGF) - BB.
IC50 yog 10 μ M. Methylnisolin inhibits phosphorylation ntawm cov teeb liab extracellular
tswj kinase 1/2 (eric1 / 2) mitogen activated protein (daim ntawv qhia) kinase induced los ntawm
PIB-BB.Methylnisolin inhibits PDGF-BB induced proliferation ntawm vascular du
cov leeg hlwb los ntawm inhibiting ERK1 / 2 MAP kinase cascade.
Related Categories: kev tshawb fawb teb > > kab mob plawv
teeb liab txoj kev > > protein tyrosine kinase > > PDGFR
teeb liab txoj kev > > MAPK / ERK teeb liab txoj kev > > ERK
kev taw qhia txoj kev > > qia hlwb thiab Wnt txoj kev > > ERK
Yam khoom: PDGFR: 10 μM (IC50)
ERK 1
ERK 2
Cov ntaub ntawv: [1].Ohkawara S, et al.Astrapterocarpan cais los ntawm Astragalus membranaceus inhibits kev loj hlob ntawm vascular du leeg hlwb.Eur J Pharmacol.2005 Nov 21;525(1-3):41-7.
Physicochemical zog ntawm Methylnissolin
Qhov ceev: 1.3 ± 0.1 g / cm3
Boiling Point: 428.9 ± 45.0 ° C ntawm 760 mmHg
Cov mis mos molecular: c17h16o5
Molecular Luj: 300.306
Flash Point: 213.2 ± 28.7 ° C
Qhov tseeb Mass: 300.099762
PSA: 57.15000
PEB: 2.45
Chav Siab: 0.0 ± 1.1 mmHg ntawm 25 ° C
Refractive Index: 1.612
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd.
Jiangsu Yongjian Pharmaceutical Technology Co., Ltd., tsim nyob rau hauv Lub peb hlis ntuj 2012, yog ib tug high-tech enterprise integrating R & D, ntau lawm thiab muag khoom.Nws yog feem ntau koom nrog hauv kev tsim khoom, kev tsim kho thiab kev tsim cov txheej txheem tsim khoom ntawm cov khoom siv ntuj tsim, tshuaj suav tshuaj siv cov ntaub ntawv thiab tshuaj impurities.Lub tuam txhab nyob rau hauv Tuam Tshoj Pharmaceutical City, Taizhou City, Jiangsu Province, nrog rau 5000 square meter ntau lawm puag thiab 2000 square meter R & D puag.Nws tsuas yog ua haujlwm rau cov koom haum tshawb fawb loj, cov tsev kawm qib siab thiab cov khoom lag luam decoction ntau lawm thoob plaws lub tebchaws.
Txog tam sim no, peb tau tsim ntau tshaj 1500 hom natural compound reagents, thiab muab piv thiab ntsuas ntau tshaj 300 hom ntaub ntawv siv, uas tuaj yeem ua tau raws li kev soj ntsuam txhua hnub ntawm cov chaw tshawb fawb loj, cov chaw soj ntsuam hauv tsev kawm ntawv thiab cov khoom siv decoction.
Raws li lub hauv paus ntsiab lus ntawm kev ntseeg zoo, lub tuam txhab vam tias yuav koom tes nrog peb cov neeg siv khoom.Peb lub hom phiaj yog ua haujlwm rau kev kho tshiab ntawm cov tshuaj suav tshuaj.
Advantageous Business Scope Ntawm Lub tuam txhab
1. R & D, ntau lawm thiab muag khoom siv tshuaj siv tshuaj ntawm cov tshuaj suav tshuaj;
2. Customized tshuaj suav tshuaj monomer tebchaw raws li tus neeg siv khoom tus yam ntxwv
3. Kev tshawb fawb txog cov txheej txheem zoo thiab cov txheej txheem kev txhim kho ntawm cov tshuaj suav tshuaj (cog) extract
4. Kev koom tes thev naus laus zis, hloov pauv thiab tshawb nrhiav tshuaj tshiab thiab txhim kho.
