Danshensu
Khoom Specification
Hom npe:Danshensu
CAS Nr:.76822-21-4
Ceev:1.5 ± 0.1 g / cm3
Molecular Formula:C9H10O5
MSDS:n / a flash point: 259.1 ± 23.8 ° C
Lub npe Askiv:Danshensu
Molecular Luj:198.17 Nws
Boiling Point:198.17 Nws
Melting Point:N/A
Lub npe Danshensu
Suav lub npe:Danshensu
Lub npe Askiv:(2R) - 3 - (3,4-dihydroxyphenyl) - 2-hydroxypropanoic acid
Suav Alias:B - (3,4-dihydroxyphenyl) lactic acid |cryptotanshinone |B - (3.4-dihydroxyphenyl) lactic acid
Danshensu bioactivity
Nqe lus piav qhia:Danshensu yog ib qho tseem ceeb ntawm Salvia miltiorrhiza, uas tuaj yeem qhib Nrf2 txoj kev taw qhia thiab tiv thaiv kab mob plawv.
Related Pawg: kev taw qhia txoj hauv kev > > autophagy > > autophagy
Teeb liab txoj kev > > NF- κ B teeb liab txoj kev > > keap1-nrf2
Kev tshawb fawb teb > > kab mob plawv
Cov khoom ntuj >> benzoic acids
Kev tshawb fawb hauv Vitro:Danshensu (DSS) txo qis cov qib ntawm cov cim enzymes (creatine kinase thiab lactate dehydrogenase) ntawm coronary outflow thiab myocardial infarction loj.Qhov no tuaj yeem txhawb nqa kev rov ua haujlwm ntawm lub plawv tom qab I / R raug mob.DSS kuj muaj ROS scavenging kev ua si thiab txhawb cov kev ua ntawm endogenous antioxidants xws li SOD, miv, MDA, GSH-Px thiab HO-1 los ntawm activating lub nuclear erythrocyte-2 ntsig txog yam 2 (Nrf2) taw qhia txoj kev kho los ntawm Akt thiab ERK1.2 hauv Western blot tsom xam [2].
Hauv Vivo Study:Kev kho mob hnyav nrog ib koob tshuaj Danshensu tsis hloov ntshav thcy nyob rau hauv nas nrog tHcy li qub.Nyob rau hauv sib piv, Danshensu ho txo tHcy nyob rau hauv nas nrog nce tHcy.Cov qib siab ntawm cysteine thiab glutathione tom qab kev kho mob nrog Danshensu qhia tau hais tias nws cov txiaj ntsig ntawm kev txo tHcy yog los ntawm kev nce kev ua haujlwm ntawm trans vulcanization txoj hauv kev [1].
Kev sim tsiaj:tag nrho cov tshuaj tau yaj nyob rau hauv saline tsuas yog tolcapone yaj nyob rau hauv saline uas muaj 20% (V / V) peg 200. Thaum lub sij hawm kev sim, nas tau yoo mov ib hmos thiab random muab rau ntau pawg.Tom qab ether tshuaj loog, kwv yees li 200 tau raug tshem tawm los ntawm cov kab mob orbital sinus μ L ntshav, ces sai sai tua kab mob nrog cawv thiab nias nrog paj rwb.Cov ntshav kuaj tam sim ntawd tau sau rau hauv cov hlab polypropylene uas muaj heparin sodium thiab centrifuged ntawm 5000 g ntawm 5 ° C rau 3 feeb.Cov qauv plasma npaj tau khaws cia ntawm -20 ℃ thiab tshuaj xyuas hauv 48 teev.
Cov ntaub ntawv:[1] YG Cao, et al.Cov txiaj ntsig zoo ntawm danshensu, ib qho tseem ceeb ntawm Salvia miltiorrhiza, ntawm homocysteine metabolism ntawm txoj kev trans-sulphuration hauv nas.Br J Pharmacol.Lub Rau Hli 2009;157(3): 482–490 : kuv.
[2].Yu J, et al.Danshensu tiv thaiv lub plawv cais tawm tsam ischemia reperfusion raug mob los ntawm kev ua kom muaj kev cuam tshuam ntawm Akt/ERK1/2/Nrf2 signaling.Int J Clin Exp Med.2015 Sep 15;8(9):14793-804.
Physicochemical zog ntawm Danshensu
Ceev:1.5 ± 0.1 g / cm3
Molecular Formula:C9H10O5
Flash Point:259.1 ± 23.8 ° C
LogP:-0.29 Nws
Refractive Index:1.659 ib
Boiling Point:481.5 ± 40.0 ° C ntawm 760 mmHg
Molecular Luj:198.17 Nws
PSA:97.990 0
Chav Siab:0.0 ± 1.3 mmHg ntawm 25 ° C
Danshensu Cov Ntaub Ntawv Kev Nyab Xeeb
PIB: 294200000
Lus Askiv lub npe ntawm Danshensu
Danshensu
Sodium (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate
(2R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid
Benzenepropanoic acid, α, 3,4-trihydroxy-, (αR)-
Benzenepropanoic acid, α, 3,4-trihydroxy-, sodium ntsev, (αR) - (1: 1)
Salvianic
