Dimethylfraxetin 6,7,8-Trimethoxycoumarin
Khoom Specification
Hom Lub Npe:ntoo tshauv element
CAS Nr:.6035-49-0
Ceev:1.2 ± 0.1 g / cm3
Molecular Formula:C12H12O5
MSDS:N / A
Lub npe Askiv:Dimethylfraxetin
Molecular Luj:236.221 ib
Boiling Point:408.0 ± 45.0 ° C ntawm 760 mmHg
Melting Point:104-105 º C
Flash Point:184.3 ± 28.8 ° C
Biological kev ua ntawm dimethylfraxetin
Nqe lus piav qhia:Dimethylfraxetin yog carbonic anhydrase inhibitor nrog Ki tus nqi ntawm 0.0097 μ M.
Pawg muaj feem:
teeb liab txoj kev > > metabolic enzyme / protease >> carbonic anhydrase
Kev tshawb fawb teb > > mob cancer
Cov khoom ntuj >> benzoic acids
Hom phiaj:ki: 0.0097 μ M (Carbonic anhydrase)[1]
Kev tshawb nrhiav hauv vitro:Hauv CA I, ib qho tseem ceeb yog dimethylfluoxetine (compound 17), nanomolar CA I inhibitor.Qhov trimethoxycoumarin no yog qhov ua tau zoo tshaj plaws ntawm NP coumarin ntawm rau CA isozymes hauv txoj kev tshawb no [1].
Kinase:Ua ntej kev txiav txim siab, tus inhibitor (xws li dimethylerythromycin) thiab cov tshuaj enzyme tau ua ntej incubated ntawm chav tsev kub rau 6 teev kom tso cai tsim cov enzyme inhibitor complex [1]
Cov ntaub ntawv:[1] Davis RA, et al.Ntuj cov khoom coumarins uas inhibit tib neeg carbonic anhydrases.Bioorg Med Chem.2013 Mar 15;21(6):1539-43.
Dimethylfraxetin
Ceev:1.2 ± 0.1 g / cm3
Boiling Point:408.0 ± 45.0 ° C ntawm 760 mmHg
Melting Point:104-105 º C
Molecular Formula:c12h 5
Molecular Luj:236.221 ib
Flash Point:184.3 ± 28.8 ° C
Qhov tseeb Mass:236.068466 ib
PSA:57.90 000 Nws
LogP:1.75 ib
Chav Siab:0.0 ± 1.0 mmHg ntawm 25 ° C
Refractive Index:1.545 Nws
Dimethylfraxetin Cov Ntaub Ntawv Kev Nyab Xeeb
Risk Statement (Tebchaws Europe): 22
Daim ntawv qhia kev nyab xeeb (Tebchaws Europe):22-45 : kuv
Kev lis kev cai Code:293220990 ib
Dimethylfraxetin Upstream Thiab Downstream Khoom
Ddimethylfraxetin Upstream Khoom
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Dimethylfraxetin Kev lis kev cai
Kev lis kev cai Code:293220990 ib
Suav txheej txheem cej luam:293220990 Lwm cov lactones VAT tus nqi: 17.0% Tax rebate tus nqi: 13.0% Regulatory conditions: tsis muaj MFN tariff: 6.5% General tariff: 20.0%
Cov ntsiab lus tshaj tawm:cov khoom npe, muaj pes tsawg leeg, cov ntsiab lus thiab lub hom phiaj
Cov ntsiab lus:2932209090. lwm lactones.VAT: 17.0%.Tus nqi se rov qab: 13.0%..MFN tariff: 6.5%.Tus nqi se: 20.0%
English Alias Of Dimethylfraxetin
6,7,8-trimethoxychromen-2-ib
6,7,8-Trimethoxy-2H-chromen-2-ib
2H-1-Benzopyran-2-ib, 6,7,8-trimethoxy-
