Fraxin;Paviin;Fraxoside;Fraxetol-8-glucoside CAS No.524-30-1
Cov ntaub ntawv tseem ceeb
CAS Nr:.524-30-1 [1] ib.
EINECS No.:208-355-5 ib
Molecular Formula:c16h18o 10
Molecular Luj:370.3081 ib
Molecular Structure:(Daim duab 1)
Khoom:Lub teeb daj acicular siv lead ua los yog flake siv lead ua.
Ceev:1.634g / cm3
Boiling Point:722.2 ° C ntawm 760 mmHg
Flash Point:267 ° C
Chav Siab:6.87e-22mmhg ntawm 25 ° C
Bioactivity ntawm Fraxin
Nqe lus piav qhia:Fraxin tuaj yeem raug cais tawm ntawm Acer tegmentosum, F. ornus thiab a.hippocastanum.Nws yog glycoside ntawm fraxine [1] thiab muaj cov tshuaj tua kab mob antioxidant, tiv thaiv kab mob thiab tiv thaiv kab mob metastasis.Fraxin nthuav tawm cov haujlwm antioxidant los ntawm inhibiting cyclic adenylate phosphodiesterase [2].
Hom phiaj:Cyclo AMP phosphodiesterase enzyme [2]
Kev tshawb fawb hauv Vitro:Fraxin (100 μ M) Nws tsis muaj cytotoxicity rau Hep G2 hlwb.Fraxin ntawm non cytotoxic concentrations txo qis t-BHP induced ROS ntau lawm nyob rau hauv ib koob tshuaj raws li [1].Fraxin (0.5 hli) tuaj yeem tshem tawm cov dawb radicals ntawm siab concentration thiab muaj cytoprotective nyhuv ntawm H2O2 kho oxidative kev nyuaj siab [2].
Hauv kev tshawb nrhiav vivo:Fraxin (50 mg / kg, PO) cuam tshuam CCl4 induced elevation ntawm ALT thiab AST.Fraxin (10 thiab 50 mg / kg, PO) txo qis GSSG qib (1.7 ± 0.3 thiab 1.5 ± 0.2 nm / g siab, feem) piv nrog GSSG qib hauv pawg CCl4 kho.
Siv:.Fraxin (50 mg / kg, po) cuam tshuam CCl4-induced elevation ntawm ALT thiab AST.Fraxin (10 thiab 50 mg / kg, po) txo qis GSSG qib (1.7 ± 0.3 thiab 1.5 ± 0.2 nM / g siab, feem) piv nrog GSSG qib ntawm pawg CCl4-kho[1].
[2].Whang WK, et al.Natural compounds, fraxin thiab chemicals structurally related fraxin tiv thaiv hlwb los ntawm oxidative kev nyuaj siab.Exp Mol Med.2005 Peb Hlis 31; 37(5): 436-46.
