Galangin CAS No.: 548-83-4
Lub cev thiab tshuaj muaj zog
Alias:Gaoliang Curcumin;3,5,7-trihydroxyflavone,
Lub npe Askiv:galangin,
English npe:3,5,7-trihydroxyflavone;3,5,7-trihydroxy-2-phenylchromen-4-ib
Molecular Structure
1. Molar refractive index: 69.55
2. Molar ntim (m3 / mol): 171.1
3. Isotonic tshwj xeeb ntim (90.2k): 519.4
4. Nto nro (dyne / cm): 84.9
5. Polarizability (10-24cm3): 27.57
Computational Chemistry
1. Tus nqi siv rau hydrophobic parameter suav (xlogp): Tsis muaj
2. Tus naj npawb ntawm cov nyiaj pub dawb hydrogen: 3
3. Tus naj npawb ntawm hydrogen bond receptors: 5
4. Number of rotatable chemical bonds: 1
5. Tus naj npawb ntawm tautomers: 24
6. Topological molecular polarity nto thaj tsam 87
7. Tus naj npawb ntawm cov atom hnyav: 20
8. Nto nqi: 0
9. Kev nyuaj siab: 424
10. Tus naj npawb ntawm isotopic atoms: 0
11. Txiav txim seb tus naj npawb ntawm atomic stereocenters: 0
12. Tus naj npawb ntawm cov tsis paub meej atomic stereocenters: 0
13. Txiav txim seb tus naj npawb ntawm cov tshuaj stereocenters: 0
14. Number of indeterminate chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Pharmacological Action
Galangin tuaj yeem hloov pauv Salmonella typhimurium TA98 thiab TA100 thiab muaj cov tshuaj tiv thaiv kab mob.
Hauv Vitro Study
Galangin inhibited catabolism ntawm DMBA nyob rau hauv ib koob tshuaj.Galangin kuj inhibited tsim DMBA-DNA adducts thiab tiv thaiv DMBA induced cell loj hlob inhibition.Hauv cov hlwb tsis zoo thiab microsomes cais tawm los ntawm DMBA kho cov hlwb, galangin tsim cov tshuaj tiv thaiv zoo ntawm CYP1A1 kev ua haujlwm ntsuas los ntawm ethoxypurine-o-deacetylase kev ua haujlwm.Kev tshuaj xyuas ntawm inhibition kinetics los ntawm ob daim duab sib txuas tau pom tias galangin inhibited CYP1A1 kev ua haujlwm hauv qhov tsis sib tw.Galangin ua rau kom nce qib CYP1A1 mRNA, qhia tias nws yuav yog ib qho agonist ntawm aromatic hydrocarbon receptor, tab sis nws inhibits CYP1A1 mRNA (TCDD) induced los ntawm DMBA los yog 2,3,5,7-tetrachlorodibenzo-p-dioxin.Galangin tseem inhibits DMBA lossis TCDD induced transcription ntawm reporter vectors uas muaj CYP1A1 txhawb nqa [1].Galangin kev kho mob inhibited cell proliferation thiab induced autophagy (130) μ M) Thiab apoptosis (370 μ M). Tshwj xeeb, kev kho galangin hauv HepG2 hlwb ua rau (1) tsub zuj zuj ntawm autophagosomes, (2) nce qib ntawm microtubule txuam nrog protein teeb saw. 3, thiab (3) nce feem pua ntawm cov cell nrog vacuoles. P53 qhia kuj nce ntxiv. Galangin induced autophagy tau attenuated los ntawm inhibiting p53 hauv HepG2 hlwb, thiab overexpression ntawm p53 nyob rau hauv Hep3B hlwb rov qab ib tug ntau dua feem pua ntawm cell vacuoles induced los ntawm galangin mus rau ib txwm theem. [2].
Kev sim ntawm tes
Cells (5.0 × 103) inoculated thiab kho nrog sib txawv concentrations ntawm galangin nyob rau hauv 96 zoo daim hlau rau txawv sij hawm.Los ntawm kev ntxiv 10 μ L ntawm 5 mg / ml MTT tov los txiav txim seb muaj pes tsawg lub hlwb nyob hauv txhua qhov dej.Tom qab incubation ntawm 37 ℃ rau 4 teev, lub hlwb tau yaj nyob rau hauv 100% tov uas muaj 20% SDS thiab 50% dimethylformamide μ L tov.Qhov ntsuas qhov muag pom tau suav nrog siv lub varioskan flash nyeem ntawv spectrophotometer ntawm qhov ntsuas wavelength ntawm 570 nm thiab siv wavelength ntawm 630 nm.
