Hyperoside; Hypercin Cas No. 482-36-0
Cov Ntaub Ntawv Tshuaj
[cov khoom npe] hypericin
[English lub npe] Hyperoside
[alias] hyperin, quercetin 3-galactoside, quercetin-3-o-galactoside
[molecular formula] c21h20o12
[molecular hnyav] 464.3763
[C as No.] 482-36-0
[Kev faib tawm tshuaj lom neeg] flavonoids
[qhov chaw] Hypericum perforatum L
[Specification]> 98%
[Safety Terminology] 1. Tsis txhob nqus plua plav.2.Thaum muaj xwm txheej lossis tsis xis nyob, nrhiav kev kho mob tam sim ntawd (qhia nws daim ntawv lo yog ua tau).
[Pharmacological efficiency] Hypericin yog dav faib.Nws yog ib qho tseem ceeb ntawm cov khoom ntuj tsim nrog ntau yam kev ua haujlwm ntawm lub cev, xws li tshuaj tiv thaiv, antispasmodic, diuretic, hnoos, txo cov ntshav siab, txo cov roj cholesterol, protein assimilation, hauv zos thiab hauv nruab nrab analgesia, thiab tiv thaiv cov hlab plawv thiab paj hlwb.
[Lub cev thiab tshuaj muaj zog] Lub teeb daj acicular siv lead ua.Lub melting point yog 227 ~ 229 ℃, thiab kho qhov muag rotation yog - 83 ° (C = 0.2, pyridine).Nws yooj yim soluble hauv ethanol, methanol, acetone thiab pyridine thiab ruaj khov nyob rau hauv ib txwm muaj.Nws reacts nrog hydrochloric acid magnesium hmoov los tsim cherry liab, thiab ferric chloride reacts ntsuab, α- Naphthol cov tshuaj tiv thaiv zoo.
[Risk Terminology] Ua phem yog nqos.
Pharmacological Action
1. Hypericin muaj cov nyhuv analgesic hauv zos, uas tsis muaj zog dua li morphine, muaj zog dua li tshuaj aspirin, thiab tsis muaj kev vam khom.Hypericin yog ib yam tshiab ntawm cov tshuaj analgesic hauv zos Tib lub sijhawm,
2. Hypericin muaj kev tiv thaiv zoo ntawm myocardial ischemia-reperfusion, cerebral ischemia-reperfusion thiab cerebral infarction.
3. Hypericin muaj cov nyhuv anti-inflammatory pom tseeb: tom qab implantation ntawm wool pob, nas tau intraperitoneally txhaj nrog 20mg / kg txhua hnub rau 7 hnub, uas cuam tshuam cov txheej txheem inflammatory.
4. Nws muaj zog antitussive nyhuv.
5. Assimilation.
6. Muaj zog inhibition ntawm aldose reductase tej zaum yuav muaj txiaj ntsig los tiv thaiv kab mob ntshav qab zib.
Kev tiv thaiv ntawm myocardial ischemia
Hypericin tuaj yeem txo qhov apoptosis ntawm cardiomyocytes tshwm sim los ntawm hypoxia reoxygenation, inhibit qhov tso tawm ntawm lactate dehydrogenase, txhim kho kev ua haujlwm ntawm myocardial superoxide dismutase (SOD) hauv cov nas nrog myocardial ischemia-reperfusion raug mob, txo qis ntawm malondialdehyde (MDA), inhibit qhov nce ntawm myocardial phosphokinase (CPK) nyob rau hauv cov ntshav, thiab txo qhov tsim ntawm oxygen dawb radical thiab nitric oxide dawb radical, thiaj li los tiv thaiv myocardium thiab txo cardiomyocyte raug mob thiab cardiomyocyte apoptosis tshwm sim los ntawm ischemia-reperfusion.
Tiv thaiv cov nyhuv ntawm cerebral ischemia
Hypericin tuaj yeem cuam tshuam qhov txo qis ntawm cov ntsiab lus formazan nyob rau hauv cov hlab ntsha ntawm lub paj hlwb tom qab hypoxia qabzib deprivation reperfusion raug mob, nce tus naj npawb ntawm cov neeg muaj sia nyob hauv cortex thiab striatum ntawm cerebral slices hauv cheeb tsam ischemic, thiab ua rau cov morphology ntawm neurons tiav thiab zoo faib.inhibit qhov txo qis ntawm kev ua haujlwm neuronal tshwm sim los ntawm hypoxia qabzib deprivation reperfusion raug mob.inhibit qhov txo qis ntawm SOD, LDH thiab glutathione peroxidase (GSHPx).Nws cov txheej txheem yuav cuam tshuam rau kev tshem tawm dawb radicals, inhibition ntawm Ca2 influx thiab tiv thaiv lipid peroxide tsim.
Kev tiv thaiv zoo ntawm daim siab thiab lub plab mucosa
Hypericin muaj peev xwm tiv thaiv kab mob ntawm daim siab thiab lub plab mucosa.Nws cov txheej txheem muaj feem xyuam rau cov nyhuv antioxidant, txhawb kev rov qab los ntawm qib N0 mus rau qhov qub thiab nce SOD kev ua haujlwm.
Antispasmodic analgesic nyhuv
Txoj kev tshawb nrhiav pom tias cov nyhuv analgesic ntawm hypericin yog tsim los ntawm kev txo Ca 2 hauv cov paj hlwb mob.Nyob rau tib lub sijhawm, hypericin tuaj yeem cuam tshuam Ca 2 influx induced los ntawm siab poov tshuaj, qhia tias hypericin kuj thaiv Ca channel hauv paj hlwb.Nws tau hais ntxiv tias hypericin tuaj yeem yog tus blocker ntawm Ca 2 channel.Kev soj ntsuam kev soj ntsuam qhia tau hais tias kev txhaj tshuaj hypericin zoo ib yam li atropine hauv kev kho mob ntawm thawj dysmenorrhea.Tsuas yog qee qhov kev mob tshwm sim tsaug zog, nws tsis muaj qhov tshwm sim tsis zoo xws li tachycardia, mydriasis thiab kub hnyiab.Nws yog ib qho zoo tagnrho antispasmodic thiab analgesic.
Cov nyhuv hypolipidemic
Hypericin tuaj yeem txo cov ntshav TC thiab nce HDL / TC piv rau cov nas rog rog, qhia tias hypericin tuaj yeem txo cov roj cholesterol, tswj cov ntshav lipid, thiab txhim kho kev ua haujlwm ntawm HDL thiab ntshav SOD hauv cov nas.Cov nyhuv no tuaj yeem txo qhov kev puas tsuaj ntawm superoxide dawb radical rau vascular endothelium hauv hyperlipidemia, thiab yog qhov tsim nyog rau kev puas tsuaj thiab metabolism ntawm lipid peroxide los tiv thaiv vascular endothelium.
Txhim khu kev tiv thaiv kab mob
Hypericin ntawm koob tshuaj 300 mg / kg thiab 150 mg / kg hauv vivo tuaj yeem cuam tshuam qhov thymus Performance index, kev loj hlob ntawm spleen T thiab B lymphocytes thiab phagocytosis ntawm peritoneal macrophages;Ntawm 59 mg / kg, nws tau txhim kho qhov loj ntawm spleen T thiab B lymphocytes thiab phagocytosis ntawm peritoneal macrophages.Hypericin ntawm koob tshuaj 50 ~ 6.25 ml hauv vitro tuaj yeem txhawb kev loj hlob ntawm spleen T thiab B lymphocytes thiab txhim kho lub peev xwm ntawm T lymphocytes los tsim IL-2;Hypericin ntawm 6.25 g / ml ua rau muaj peev xwm ntawm nas peritoneal macrophages kom phagocytize neutrophils, xws li 12.5 mus rau 3.12 μ G / ml ua rau muaj peev xwm ntawm nas peritoneal macrophages kom tso tawm No.
Antidepressant nyhuv
Hypothalamic pituitary adrenal (HPA) activation yog ib qho kev hloov pauv lom neeg hauv cov neeg mob uas muaj kev nyuaj siab loj, uas yog tus cwj pwm los ntawm kev tso tawm ntau dhau ntawm adrenocorticotropic hormone (ACTH) thiab cortisol.Hypericin tuaj yeem tswj hwm txoj haujlwm ntawm HPA axis thiab txo cov qib ACTH thiab corticosterone, thiaj li ua lub luag haujlwm tiv thaiv kev ntxhov siab.
Tshuaj tiav lawm
Ciwujia capsule
Acanthopanax senticosus capsule yog ib qho kev npaj nrog Acanthopanax senticosus qia thiab nplooj extract ua raw khoom.Lub ntsiab tivthaiv yog flavonoids, nyob rau hauv uas hypericin yog lub ntsiab active tivthaiv ntawm Acanthopanax senticosus nplooj.
Cov ntsiab lus tseem ceeb: txhawb cov ntshav ncig thiab tshem tawm cov ntshav stasis.Nws yog siv rau hauv siab arthralgia thiab kab mob plawv los ntawm cov ntshav stasis.Cov tsos mob muaj xws li mob hauv siab, lub hauv siab nruj, palpitations, kub siab, thiab lwm yam. nws belongs rau deficiency ntawm spleen thiab raum thiab ntshav stasis thiab Yin.
Xinan ntsiav tshuaj
Nws yog ib qho kev npaj ua los ntawm hawthorn nplooj extract, uas yog nplua nuj nyob rau hauv flavonoids, nyob rau hauv uas hypericin yog ib tug ntawm cov tseem ceeb Cheebtsam.
Cov ntsiab lus tseem ceeb: nthuav cov kab mob plawv, txhim kho cov ntshav myocardial thiab txo cov ntshav lipid.Nws yog siv los kho cov kab mob plawv, angina pectoris, hauv siab nruj, palpitation, kub siab, thiab lwm yam.
Qiyue Jiangzhi ntsiav tshuaj
Qiyue Jiangzhi ntsiav tshuaj yog cov tshuaj suav tshuaj suav tshuaj ntshiab lipid-txo cov tshuaj npaj los ntawm kev rho tawm cov txiaj ntsig zoo ntawm cov tshuaj suav tshuaj xws li hawthorn (enucleated) thiab Astragalus membranaceus.Ib qho ntawm cov khoom tseem ceeb ntawm hawthorn yog flavonoids, uas muaj cov ntsiab lus hypericin siab.
Cov ntsiab lus tseem ceeb: txo cov ntshav lipid thiab ua kom cov hlab ntsha mos.Nws yog siv los txhim kho cov hlab ntshav ncig thiab tiv thaiv arrhythmia thiab hyperlipidemia.
Xinxuening ntsiav tshuaj
Xinxuening ntsiav tshuaj yog ib qho kev npaj ua los ntawm cov tshuaj suav tshuaj xws li hawthorn thiab pueraria.Hawthorn yog cov tshuaj ntawm peb tog.Nws muaj ursolic acid, Vitexin rhamnoside, hypericin, citric acid, thiab lwm yam, uas hypericin yog cov khoom tseem ceeb.
Cov ntsiab lus tseem ceeb: txhawb cov ntshav ncig thiab tshem tawm cov ntshav stasis, dredging collaterals thiab relieving mob.Nws yog siv rau hauv siab arthralgia thiab vertigo tshwm sim los ntawm lub plawv ntshav stasis thiab lub hlwb collaterals, nrog rau cov kab mob plawv, kub siab, angina pectoris thiab hyperlipidemia.
Yukexin ntsiav tshuaj
Yukexin capsule yog ib hom tshuaj suav tshuaj npaj tsim los ntawm cov tshuaj thaum ub, uas yog tsim los ntawm Hypericum perforatum, qus jujube kernel, Albizzia bark, Gladiolus thiab lwm yam tshuaj suav tshuaj.Nws tsuas yog muaj hypericin, quercetin, quercetin, chlorogenic acid, caffeic acid, yimaning, hypericin thiab lwm yam.
Cov ntsiab lus tseem ceeb: kev puas siab puas ntsws tshwm sim los ntawm kev so ntawm daim siab qi thiab lub siab tsis zoo.
