Cov khoom

Naringin yog aglycone ntawm naringin thiab belongs rau dihydroflavonoids.Nws muaj cov haujlwm ntawm cov kab mob tua kab mob, tiv thaiv kab mob, dawb radical scavenging, antioxidant, hnoos thiab expectorant, ntshav lipid txo, tiv thaiv qog noj ntshav, antispasmodic thiab cholagogic, tiv thaiv thiab kho kab mob siab, inhibition ntawm platelet coagulation, tiv thaiv atherosclerosis thiab lwm yam.Nws tuaj yeem siv dav hauv tshuaj, zaub mov thiab lwm yam haujlwm.

Tshuaj tua kab mob
Nws muaj cov tshuaj tua kab mob muaj zog ntawm Staphylococcus aureus, Escherichia coli, dysentery thiab typhoid bacillus.Naringin kuj muaj qhov cuam tshuam rau fungi.Txau 1000ppm ntawm mov tuaj yeem txo tus kab mob Magnaporthe grisea los ntawm 40-90%, thiab tsis muaj tshuaj lom rau tib neeg thiab tsiaj txhu.

Antiinflammatory
Cov nas tsuag tau txhaj tshuaj intraperitoneally nrog 20mg / kg txhua hnub, uas cuam tshuam cov txheej txheem inflammatory tshwm sim los ntawm wool pob implantation.Galati et al.Pom tau tias txhua pawg koob tshuaj naringin muaj cov tshuaj tiv thaiv kab mob los ntawm kev sim nas pob ntseg ntsiav tshuaj, thiab cov tshuaj tiv thaiv kab mob tau nce ntxiv nrog kev nce koob tshuaj.Qhov inhibition tus nqi ntawm pab pawg neeg siab yog 30.67% nrog thickness sib txawv thiab 38% nrog hnyav sib txawv.[4] Feng Baomin et al.Induced theem 3 dermatitis nyob rau hauv nas los ntawm DNFB txoj kev, thiab ces muab naringin qhov ncauj rau 2 ~ 8 hnub los soj ntsuam cov inhibition nqi ntawm tam sim no theem (IPR), lig theem (LPR) thiab ultra lig theem (VLPR).Naringin tuaj yeem cuam tshuam pob ntseg edema ntawm IPR thiab VLPR, thiab muaj qee yam kev txhim kho tus nqi hauv kev tiv thaiv.

Kev tiv thaiv kab mob
Naringin tswj qhov tsim nyog sib npaug ntawm oxidative siab hauv lub sijhawm tshwj xeeb thiab cov cheeb tsam tshwj xeeb los ntawm kev tswj cov dej ntws ntawm electrons hauv mitochondria.Yog li ntawd, kev ua haujlwm immunomodulatory ntawm naringin yog qhov sib txawv ntawm cov tshuaj tiv thaiv kab mob yooj yim lossis tshuaj tiv thaiv kab mob.Nws tus yam ntxwv yog tias nws tuaj yeem rov ua kom lub cev tsis muaj zog (pathological xeev) mus rau qhov ze ntawm lub cev tiv thaiv kab mob (lub cev lub cev), Tsis yog kev txhawb nqa los yog inhibiting lub cev tiv thaiv kab mob.

Poj niam kev cai coj khaub ncaws
Naringin muaj cov haujlwm zoo ib yam li cov tshuaj uas tsis yog steroidal anti-inflammatory.Nws tuaj yeem txo cov synthesis ntawm prostaglandin PGE2 los ntawm inhibiting cyclooxygenase Cox, thiab ua lub luag haujlwm ntawm antipyretic, analgesic thiab alleviating o.
Raws li cov tshuaj estrogen zoo li cov nyhuv ntawm naringin, naringin tuaj yeem siv rau kev hloov tshuaj estrogen hauv cov poj niam postmenopausal kom tsis txhob muaj qhov tsis zoo tshwm sim los ntawm kev siv tshuaj estrogen mus ntev.

Cov teebmeem rau kev rog
Naringin muaj cov txiaj ntsig kho mob pom tseeb ntawm hyperlipidemia thiab rog rog.
Naringin tuaj yeem txhim kho cov ntshav plasma siab concentration, TG (triglyceride) concentration thiab dawb fatty acid concentration hauv cov nas rog rog.Nws tau pom tias naringin tuaj yeem tswj hwm monocyte peroxisome proliferator activated receptor hauv cov qauv rog rog δ, Txo cov ntshav lipid.
Los ntawm kev sim tshuaj, nws tau pom tias cov neeg mob hypercholesterolemia tau noj ib ntsiav tshuaj uas muaj 400mg naringin txhua hnub rau 8 lub lis piam.Cov concentrations ntawm TC thiab LDL cov roj cholesterol hauv plasma txo qis, tab sis qhov ntau ntawm TG thiab HDL cov cholesterol tsis hloov pauv ntau.
Hauv kev xaus, naringin tuaj yeem txhim kho hyperlipidemia, uas tau lees paub zoo hauv kev sim tsiaj thiab kev sim tshuaj.

Tshem tawm cov dawb radicals thiab antioxidation
DPPH (dibenzo iab acyl radical) yog ib qho dawb radical ruaj khov.Nws lub peev xwm los tshem tawm cov dawb radicals tuaj yeem ntsuas los ntawm nws 517 nm absorbance attenuation.[6] Kroyer kawm txog cov nyhuv antioxidant ntawm naringin los ntawm kev sim thiab paub tseeb tias naringin muaj cov nyhuv antioxidant.[7] Zhang HJ et al.Kev sim cov txheej txheem ntawm lipid peroxidation ntawm LDL los ntawm colorimetry thiab lub peev xwm los inhibit oxidative hloov ntawm LDL.Naringin feem ntau chelates Cu2 + los ntawm nws cov 3-hydroxyl thiab 4-carbonyl pawg, los yog muab cov proton thiab dawb radical neutralization, los yog tiv thaiv LDL los ntawm lipid peroxidation los ntawm nws tus kheej oxidation.Zhang Haide thiab lwm tus pom tias naringin muaj cov txiaj ntsig zoo dawb radical scavenging los ntawm DPPH txoj kev.Cov nyhuv dawb radical scavenging tuaj yeem pom tau los ntawm hydrogen oxidation ntawm naringin nws tus kheej.[8] Peng Shuhui et al.Siv cov qauv kev sim ntawm lub teeb riboflavin (IR) - nitrotetrazolium chloride (NBT) - spectrophotometric los ua pov thawj tias naringin muaj qhov pom tseeb scavenging nyhuv ntawm reactive oxygen hom O2 -, uas muaj zog tshaj li ascorbic acid nyob rau hauv kev tswj zoo.Cov txiaj ntsig ntawm kev sim tsiaj tau pom tias naringin muaj cov nyhuv inhibitory ntawm lipid peroxidation hauv nas hlwb, lub plawv thiab daim siab, thiab tuaj yeem txhim kho kev ua haujlwm ntawm superoxide dismutase (SOD) hauv nas tag nrho cov ntshav.

Kev Tiv Thaiv Kab Mob
Naringin thiab naringin tuaj yeem ua rau cov haujlwm ntawm acetaldehyde reductase (ADH) thiab acetaldehyde dehydrogenase (ALDH), txo cov ntsiab lus ntawm triglycerides hauv daim siab thiab tag nrho cov roj (cholesterol) hauv cov ntshav thiab daim siab, nce cov ntsiab lus ntawm cov roj lipoprotein ntau ntom ntom (HDLC), nce qhov sib piv. ntawm HDLC rau tag nrho cov roj cholesterol, thiab txo cov atherogenic Performance index tib lub sijhawm, Naringin tuaj yeem txhawb nqa kev thauj cov roj cholesterol los ntawm plasma mus rau daim siab, cov kua tsib tso tawm thiab tso tawm, thiab inhibit qhov hloov pauv ntawm HDL rau VLDL lossis LDL.Yog li, naringin tuaj yeem txo qhov kev pheej hmoo ntawm arteriosclerosis thiab kab mob plawv.Naringin tuaj yeem txo cov ntsiab lus ntawm tag nrho cov roj cholesterol hauv ntshav thiab ntxiv dag zog rau nws cov metabolism.

Cov nyhuv Hypolipidemic
Zhang Hai et al.Kev ntsuas cov roj (cholesterol) hauv cov ntshav (TC), qis lipoprotein cholesterol tsawg (LDL-C), ntshav siab lipoprotein cholesterol (HDL-C), triglyceride (TG) thiab lwm yam khoom ntawm cov nas tom qab txhaj tshuaj los ntawm kev sim tsiaj cov txiaj ntsig tau pom tias naringin tuaj yeem txo qis. ntshav TC, TG thiab LDL-C thiab kuj nce cov ntshav HDL-C ntawm ib qho koob tshuaj, qhia tias naringin muaj cov txiaj ntsig ntawm kev txo cov ntshav lipid hauv cov nas.[

Antitumor Activity
Naringin tuaj yeem tswj hwm kev tiv thaiv kab mob thiab inhibit qog kev loj hlob.Naringin muaj kev ua haujlwm ntawm nas leukemia L1210 thiab sarcoma.Cov txiaj ntsig tau pom tias thymus / lub cev hnyav piv ntawm cov nas tau nce ntxiv tom qab kev tswj hwm qhov ncauj ntawm naringin, qhia tias naringin tuaj yeem txhim kho lub cev tiv thaiv kab mob.Naringin tuaj yeem tswj hwm qib ntawm T lymphocytes, kho cov kab mob hauv nruab nrab ntawm lub cev tsis muaj zog uas tshwm sim los ntawm qog los yog xov tooj cua thiab kws khomob, thiab txhim kho kev tua cov qog nqaij hlav cancer.Nws tau tshaj tawm tias naringin tuaj yeem nce qhov hnyav ntawm thymus hauv ascites mob qog noj ntshav hauv nas, qhia tias nws tuaj yeem txhim kho lub cev tsis muaj zog thiab txhawb nqa nws lub peev xwm los tiv thaiv qog noj ntshav.Nws tau pom tias pomelo tev extract muaj inhibitory nyhuv ntawm S180 sarcoma, thiab qog inhibition tus nqi yog 29.7%.

Antispasmodic thiab cholagogic
Nws muaj cov txiaj ntsig zoo hauv flavonoids.Naringin kuj tseem muaj txiaj ntsig zoo rau kev ua kom cov kua tsib tso tawm ntawm cov tsiaj sim.

Antitussive Thiab Expectorant nyhuv
Siv phenol liab ua ib qho qhia txog kev tshem tawm cov kab mob, qhov kev sim qhia tau hais tias naringin muaj zog hnoos thiab expectorant nyhuv.

Daim ntawv thov kev kho mob
Nws yog siv los kho cov kab mob kab mob, sedative thiab anticancer tshuaj.
Daim ntawv thov ntau npaum li cas: suppository, lotion, txhaj tshuaj, ntsiav tshuaj, tshuaj ntsiav, thiab lwm yam.