Neohesperidin
Kev siv ntawm Synephrine Hydrochloride
Neohesperidin yog ib hom flavonoid compound uas muaj dav hauv Cucurbitaceae cov nroj tsuag thiab muaj cov tshuaj tua kab mob antioxidant thiab tiv thaiv kab mob./h2>
Lub npe Neohesperidin
Lub npe Askiv: neohesperidin
Suav Alias: neohesperidin |tshuaj neohesperidin
Bioactivity ntawm Neohesperidin
Nqe lus piav qhia: neohesperidin yog ib qho flavonoid compound pom nyob rau hauv Cucurbitaceae, uas muaj cov tshuaj tiv thaiv antioxidant thiab tiv thaiv kab mob.
Related qeb: teeb liab txoj kev > > lwm yam > > lwm yam
kev tshawb fawb teb >> mob / tiv thaiv kab mob
Khoom noj khoom haus > > flavonoids
Kev tshawb fawb hauv Vitro:
Tshiab hesperidin induces apoptosis nyob rau hauv tib neeg lub mis mob cancer MDA-MB-231 hlwb.IC50 qhov tseem ceeb ntawm neohesperidin ntawm 24 thiab 48 teev yog 47.4 ± 2.6, raws li μ M thiab 32.5 ± 1.8 μ M. Qhov kev qhia ntawm p53 thiab Bax tau nce siab- tswj hauv neohesperidin kho cov hlwb, thaum qhov kev qhia ntawm Bcl-2 poob qis. tswj [1].Neohesperidin pom muaj kev ua haujlwm antioxidant hauv DPPH radical scavenging test (IC50 = 22.31 μ g / mL) [2].
Hauv Vivo Txoj Kev Kawm: neohesperidin (50mg / kg) cuam tshuam 55.0% HCl / ethanol ua rau mob plab.Hauv pylorus ligated nas, neohesperidin (50 mg / kg) txo qis hauv plab hnyuv thiab cov kua qaub tso zis thiab nce pH [1].Kev kho Neohesperidin txo qis ntshav qabzib sai, ntshav qabzib thiab glycosylated serum protein (GSP) hauv cov nas.Nws ua rau muaj qhov ua rau qhov ncauj qabzib thiab ua rau cov tshuaj insulin rhiab heev, thiab txo qis cov tshuaj insulin hauv cov nas ntshav qab zib.Neohesperidin txo qis cov ntshav triglycerides, tag nrho cov roj cholesterol, qib leptin thiab daim siab Performance index hauv nas [3].
Kev sim tsiaj: nas: Txhua tus nas yoo mov 6 teev ua ntej qhov kev sim, thiab tom qab ntawd tau noj nrog dej lossis neohesperidin los ntawm kev pub mis.Rau OGTT thiab ITT, nas tau txhaj tshuaj intraperitoneally nrog 2G / kg BW qabzib lossis 1iu / kg BW insulin, feem.Cov ntshav kuaj tau raug sau los ntawm cov hlab ntsha caudal los ntsuas cov ntshav qabzib hauv cov ntshav (0 feeb) ua ntej txhaj cov piam thaj lossis insulin.Cov ntshav qabzib ntxiv tau ntsuas ntawm 30, 60, 90 thiab 120 feeb [3].
Cov ntaub ntawv: [1].Li JH, et al.Kev tiv thaiv cov teebmeem ntawm neohesperidin thiab poncirin cais los ntawm cov txiv hmab txiv ntoo ntawm Poncirus trifoliata ntawm cov kab mob plab.Phytother Res.2009 Dec; 23(12): 1748-53.
[2].Xu F, et al.Neohesperidin induces cellular apoptosis nyob rau hauv tib neeg lub mis adenocarcinoma MDA-MB-231 hlwb ntawm activating Bcl-2 / Bax-mediated signaling txoj kev.Nat Prod Commun.2012 Nov; 7(11):1475-8.
[3].Jia S, et al.Hypoglycemic thiab hypolipidemic cuam tshuam ntawm neohesperidin muab los ntawm Citrus aurantium L. hauv cov kab mob ntshav qab zib KK-A(y) nas.Food Funct.Peb Hlis 2015; 6(3): 878-86.
Physicochemical Properties ntawm Neohesperidin
Qhov ceev: 1.7 ± 0.1 g / cm3
Boiling Point: 933.7 ± 65.0 ° C ntawm 760 mmHg
Melting Point: 239-243 ºC
Cov roj formula: C28H34O15
Molecular Luj: 610.561
Flash Point: 306.7 ± 27.8 ° C
PIB: 610.189758
PSA: 234.29000
PEB: 2.44
Cov tsos mob: 0.0 ± 0.3 mmHg ntawm 25 ° C
Chav Siab: 0.0 ± 0.3 mmHg ntawm 25 ° C
Refractive Index: 1.695
Cia txias: 2-8 ° C
Tshiab Hesperidin Cov Ntaub Ntawv Kev Nyab Xeeb
Cov khoom siv tiv thaiv tus kheej: cov ntaub thaiv qhov muag;hnab looj tes;hom N95 (US);Hom P1 (EN143) lub tshuab ua pa lim
Daim Ntawv Qhia Txog Kev Nyab Xeeb (Tebchaws Europe): s22-s24 / 25
Kev thauj mus los ntawm cov khoom txaus ntshai: nonh rau txhua hom kev thauj
Wg Germany: 3
RTECS No.: dj2981400
Cov ntawv nyeem Neohesperidin
Kev sib piv metabolic thiab transcriptional tsom xam ntawm ib tug doubled diploid thiab nws cov diploid citrus rootstock (C. junos cv. Ziyang xiangcheng) qhia nws muaj peev xwm tus nqi rau kev nyuaj siab kuj txhim kho.
BMC cog Biol.15, 89, (2015)
Polyploidy feem ntau tau txiav txim siab los muab cov nroj tsuag kom hloov tau zoo dua rau ib puag ncig kev ntxhov siab.Tetraploid citrus rootstocks yuav tsum muaj zog tiv thaiv kev nyuaj siab dua li diploid.Muaj ntau...
Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses mob qog noj ntshav los ntawm kev cuam tshuam nrog epithelial-rau-mesenchymal hloov hauv SKOV3 hlwb.
Chin.Med.10, 14, (2015)
Ougan (Citrus reticulata cv. Suavissima) flavedo extract (OFE) muaj peev xwm los tiv thaiv qog nqaij hlav nrog cov txheej txheem tsis meej.Txoj kev tshawb no yog tsom los ntsuas qhov muaj peev xwm tiv thaiv metastatic acti ...
Hesperidin, nobiletin, thiab tangeretin yog koom ua ke rau lub luag haujlwm rau kev tiv thaiv neuroinflammatory muaj peev xwm ntawm tangerine tev (Citri reticulatae pericarpium).
Khoom noj khoom haus Chem.Toxicol.71, 176-82, (2014)
Inhibiting microglial activation-mediated neuroinflamation tau dhau los ua lub hom phiaj rau kev txhim kho cov khoom noj khoom haus los kho cov kab mob neurodegenerative.Tangerine tev (Citri reticulata ...
English Alias Of Neohesperidin
HESPERETIN-7-NEOHESPERIDOSIDE
Hesperetin 7-neohesperidoside
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (2S)-
(2S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-α-L-) mannopyranosyl)-β-D-glucopyranoside
hesperetin 7-O-neohesperoside
Neohesperdin
Neohesperdin
TIAB SA 00017357
Hesperetin-7-O-neohesperidoside
IB 236-216-9
(S)-4'-Methoxy-3',5,7-trihydroxyflavanone-7-[2-O-(α-L-rhamnopyranosyl)-β-D-glucopyranoside]
4H-1-Benzopyran-4-one, 2,3-dihydro-7-((2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-5-hydroxy-2 -(3-hydroxy-4-methoxyphenyl)-, (S)-
Tom ntej: Hesperetin 7-O-neohesperidoside
