Ophiopogonin D Cas No.945619-74-9
Ophiopogon Saponin D Lub Npe
Lub npe Askiv:(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside
Bioactivity ntawm Ophiopogon Japonicus Saponin D
Nqe lus piav qhia:Ophiopogon D yog ib qho tsis tshua muaj ntuj C29 steroidal glycoside cais tawm ntawm tuber ntawm Ophiopogon japonicus.Ophiopogonin D yog CYP2J3 inducer uas nce CYP2J2 / eets thiab PPAR nyob rau hauv tib neeg umbilical leeg endothelial cells (HUVECs) α Kev qhia ntawm Ang II cuam tshuam Ang II induced NF- κ B nuclear translocation, I κ B α Down regulation, Ca2 + intracellular overload thiab ua kom cov proinflammatory cytokines.Ophiopogonin D tau siv los kho mob thiab kab mob plawv rau ntau txhiab xyoo.
Pawg muaj feem
Kev taw qhia txoj kev > > transmembrane thauj > > calcium channel
Kev tshawb fawb teb > > kab mob plawv
Kev taw qhia txoj hauv kev > > cell voj voog / DNA puas > > PPAR
Kev tshawb fawb teb >> mob / tiv thaiv kab mob
Hom phiaj
PIB α
NF- IB
Ca2+
Cov ntaub ntawv siv:[1].Wang L, et al.Homo-aro-cholestane, furostane thiab spirostane saponins los ntawm tubers ntawm Ophiopogonjaponicus.Phytochemistry.Peb Hlis 2017; 136:125-132.
[2].Huang X, et al.Ophiopogonin D thiab EETs ameliorate Ang II-induced inflammatory teb ntawm activating PPARα hauv HUVECs.Biochem Biophys Res Commun.2017 Aug 19;490(2):123-133.
English Alias ntawm Ophiopogon saponin D
(1β,3β,25R)-3-Hydroxyspirost-5-en-1-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)] -6-deoxy-β-D-galactopyranoside β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[β-D-xylopyranosyl-(1->3)]-6-deoxy-
(2S,3R,4R,5R,6S)-2-((((2R,3R,4S,5S,6R)-5-hydroxy-2-((((4R,5'R,6R,6aR,6bS,8aS) 8bR,9S,10R,11aS,12aS,12bS)-4-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a, 6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2 '-pyran]-6-yl)oxy)-6-methyl-4-((((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro- 2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol
Ophiopogonin D
Deacetylophiopogonin C
