Salvianolic acid C
Lub hom phiaj
Salvianolic acid C yog ib qho tsis sib tw inhibitor ntawm cytochrome p4502c8 (cyp2c8) thiab sib xyaw inhibitor ntawm cytochrome P4502J2 (CYP2J2) nrog nruab nrab siv.Nws cov txiaj ntsig Ki rau cyp2c8 thiab CYP2J2 yog 4.82 raws li μ M thiab 5.75 μ M
Lub npe Askiv
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
English Alias
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]prop-2 -enoyl}oxy) propanoic acid
(2R)-3-(3,4-Dihydroxyphenyl)-2-({(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-1-benzofuran-4-yl]-2- propenoyl}oxy) propanoic acid
Benzenepropanoic acid, α-[[(2E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-benzofuranyl]-1-oxo-2-propen-1-yl]oxy]-3, 4-dihydroxy-, (αR)-
Salvianolic acid C
Physicochemical Properties Ntawm Salvianolic Acid C
Qhov ceev: 1.6 ± 0.1 g / cm3
Boiling Point: 844.2 ± 65.0 ° C ntawm 760 mmHg
Cov roj formula: C26H20O10
Molecular Luj: 492.431
Flash point: 464.4 ± 34.3 ° C
PIB: 492.105652
PSA: 177.89000
PIB: 3.12
Chav Siab: 0.0 ± 3.3 mmHg ntawm 25 ° C
Refractive Index: 1.752
Bioactivity Ntawm Salvianolic Acid C
Nqe lus piav qhia:
Salvianolic acid C yog ib qho tsis sib tw inhibitor ntawm cytochrome p4502c8 (cyp2c8) thiab sib xyaw inhibitor ntawm cytochrome P4502J2 (CYP2J2) nrog nruab nrab siv.Nws cov txiaj ntsig Ki rau cyp2c8 thiab CYP2J2 yog 4.82 raws li μ M thiab 5.75 μ M.
Pawg muaj feem:
Kev taw qhia txoj hauv kev>> metabolic enzyme / protease>> cytochrome P450
Kev tshawb fawb teb > > mob cancer
Natural Products > > lwm yam
Hom phiaj:
CYP2C8: 4.82 μM (Ki)
CYP2J2: 5.75 μM (Ki)
Kev tshawb fawb hauv Vitro:
Salvianolic acid C yog ib qho tshuaj sib xyaw ua ke ntawm cov tsis sib tw cyp2c8 inhibitor thiab CYP2J2.KIS ntawm cyp2c8 thiab CYP2J2 yog 4.82 thiab 5.75 raws li μ M[1].Salvianolic acid C txo qis kev qhia ntawm iNOS.Salvianolic acid C inhibits LPS induced TNF- α, IL-1 β, IL-6 thiab IL-10 yog overproduced.Salvianolic acid C inhibits LPS induced NF- κ B activation.Salvianolic acid C kuj nce qhov kev qhia ntawm Nrf2 thiab HO-1 hauv BV2 microglia [2].
Hauv Vivo Studies:
Salvianolic acid C (20mg / kg) kev kho mob txo qis kev khiav tawm latency.Tsis tas li ntawd, SALC (10 thiab 20 mg / kg) kev kho mob tau nce ntau ntawm cov platform hla piv nrog LPS qauv pawg.Piv nrog rau pawg qauv, kev tswj hwm kev tswj hwm ntawm salvianolic acid C hauv lub hlwb tswj hwm TNF- α, IL-1 β Thiab IL-6 qib.Cov theem ntawm iNOS thiab COX-2 nyob rau hauv cerebral cortex thiab hippocampus ntawm nas yog siab dua cov nyob rau hauv pawg tswj, thaum salvianolic acid C kev kho mob txo qis tswj lub cortex thiab hippocampus.Salvianolic acid C (5, 10 thiab 20 mg / kg) kev kho mob nce p-ampk, Nrf2, HO-1 thiab NQO1 qib hauv cov nas cerebral cortex thiab hippocampus nyob rau hauv ib koob tshuaj [2].
Siv:
[1].Xu MJ, et al.Inhibitory Effects ntawm Danshen Cheebtsam ntawm CYP2C8 thiab CYP2J2.Chem Biol Interact.2018 Lub Rau Hli 1;289:15-22.
[2].Song J, et al.Ua kom Nrf2 signaling los ntawm salvianolic acid C attenuates NF κ B mediated inflammatory teb ob leeg hauv vivo thiab hauv vitro.Int Immunopharmacol.2018 Peb Hlis;63:299-310.
