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Synephrine Use

Synephrine (oxedrine) is derived from citrus plants α- Adrenergic and β- Adrenergic agonists have sympathomic and structural similarities with ephedra and ephedrine alkaloids.

Name Of Synephrine

English Name: synephrine
Chinese alias: deoxyepinephrine | simforine | DL deoxyepinephrine | 1-p-hydroxyphenyl-2-methylaminoethanol | cinephrine | 1 – (4-hydroxyphenyl) – 2 – (methylamino) ethanol

Bioactivity Of Synephrine

Description: synephrine (oxedrine) is derived from citrus plants α- Adrenergic and β- Adrenergic agonists have sympathomic and structural similarities with ephedra and ephedrine alkaloids.

Relevant Categories: α- adrenergic and β- adrenergic[1]

In Vivo Study: adrenaline (1mg / kg; oral gavage; lasting for 8 days; PVL and BDL rats) significantly improved the hyperkinetic state of PVL and BDL rats. PVL and BDL rats significantly decreased portal vein pressure, portal vein branch bleeding flow and cardiac index, while adrenaline treatment increased mean arterial pressure and systemic and portal vein vascular resistance [2]. Animal model: Rats with portal vein ligation (PVL) or bile duct ligation (BDL) [2] dose: 1 mg / kg every 12 hours: oral gavage; Results on day 8: PVL and BDL rats had significantly decreased portal vein pressure, portal branch blood flow and cardiac index, and increased mean arterial pressure and systemic and portal vein resistance

References: 1]  Thomas JE, et al. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009; 36(6):586-90.

[2].  Huang YT, et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb; 85(2):183-8.

Physicochemical Properties Of  Simephrine

Density: 1.2 ± 0.1 g / cm3

Boiling Point: 341.1 ± 27.0 ° C at 760 mmHg

Melting point: 187 ° C (Dec.) (lit.)

Molecular Formula: C9H13NO2

Molecular Weight: 167.205

Flash point: 163.4 ± 14.3 ° C

Exact mass: 167.094635

PSA:52.49000

LogP:-0.03
Appearance: off white to beige powder

Steam Pressure: 0.0 ± 0.8 mmHg at 25 ° C

Refractive Index: 1.572

Storage Conditions: This product should be sealed and stored.

Safety Information Of Synflynn

Symbol: ghs07

Signal word: warning

Hazard statement: h315-h319-h335

Warning statement: p261-p305 + P351 + P338

Personal protective equipment: dust mask type N95 (US); Eyeshields; Gloves

Hazard code (Europe): Xi: iritant;

Risk statement (Europe): R36 / 37 / 38

Safety statement (Europe): s26-s36

Transport code of dangerous goods: nonh for all modes of transport

RTECS No.: do7350000
Customs Code: 2922199090

Synephrine Preparation
Results of citrus aurantium L.
 Synephrine Customs
Customs Code: 29225090

Chinese overview: 29225090 Other amino alcohol phenols, amino acid phenols and other oxygenated amino compounds VAT rate: 17.0% Tax rebate rate: 13.0% Regulatory conditions: ab. MFN tariff: 6.5% General tariff: 30.0%

Declaration Elements: product name, composition, content, purpose, chroma of ethanolamine and its salt shall be reported, and packaging of ethanolamine and its salt shall be reported

Supervision conditions: A. customs clearance form for Inbound Goods B. customs clearance form for outbound goods

Inspection And Quarantine: R. sanitary supervision and inspection of imported food S. sanitary supervision and inspection of exported food
Summary:2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synephrine Literature

Phytochemical profile and antioxidant activity of physiological drop of citrus fruits.
J. Food Sci. 78(1) , C37-42, (2013)
The phytochemical content and the antioxidant activity (AA) of physiological drop of the main citrus species grown in China were investigated. Among the flavonoids, hesperidin was found mostly in mand…

Simultaneous analysis of amphetamine-type stimulants in plasma by solid-phase microextraction and gas chromatography-mass spectrometry.
J. Anal. Toxicol. 38(7) , 432-7, (2014)
Brazil is considered one of the countries with the highest number of amphetamine-type stimulant (ATS) users worldwide, mainly diethylpropion (DIE) and fenproporex (FEN). The use of ATS is mostly linke..

In situ synthesis of homochiral metal-organic framework in capillary column for capillary electrochromatography enantioseparation.
J. Chromatogr. A. 1388 , 207-16, (2015)
Homochiral metal-organic frameworks (MOFs) are promising as porous stationary phase for open-tubular capillary electrochromatography (OT-CEC) enantioseparation owing to their fine-tuned pore sizes and…

English Alias Of Synephrine

Synefrin

Simpatol

EINECS 202-300-9

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol

(-)-Oxedrine

Oxedrine

(-)-Sympatol

(R)-4-(1-hydroxy-2-(methylamino)ethyl)phenol

1-(4-Hydroxyphenyl)-2-methylaminoethanol

Synephrin

Ethaphene

Analeptin

Simpalon

(-)-Synephrine

Benzenemethanol, 4-hydroxy-α-[(methylamino)methyl]-, (αR)-

Synephrine

MFCD00002370

D-Synephrine

(-)-4-hydroxy-α-[(methylamino)methyl]benzenemethanol

Sympathol

Pentedrin

(-)-p-hydroxy-α-[(methylamino)methyl]benzyl alcohol