Jujuboside A CAS No 55466-04-1
Enfòmasyon esansyèl
alyas Chinwa:jujube kernel saponin A, jujube kernel saponin A;Jujube nwayo saponin A (estanda)
Non angle:Jujuboside A
Sous plant:li soti nan grenn jujube sovaj, ke yo rele tou nwayo jujube ak nwayo jujube sovaj.
Fòmil molekilè:C58H94O26
Pwa molekilè:1207.35
Nimewo CAS55466-04-1
Byoaktivite Jujuboside A
Sib:GABA reseptè, mTOR, PI3K, Akt [1] [2]
Etid in vitro:dòz ki ba 41 μ Jujuboside A nan M (apeprè 0.05 g / L) pwovoke GABA (a) reseptè pandan 24 ak 72 h tretman α 1， α 5， β 2 subunit mRNA ogmante anpil.Dòz segondè 82 μ M (apeprè 0.1 g / L) Jujuboside A siyifikativman ogmante reseptè GABA (a) nan 24 èdtan α 1， α 5 nivo mRNA sou-inite ak diminye nivo β 2 sou-inite mRNA ak diminye GABA (a) reseptè α 1， Ekspresyon β 2 mRNA te trete nan 72 èdtan [1].Jujuboside Yon pretreatman ka ranvèse diminisyon nan viabilite selil ak pi byen pwovoke ISO pwovoke blesi selil H9c2.Jujuboside A ka akselere fosforilasyon PI3K, Akt ak mTOR.Jujuboside A ka siyifikativman redwi pwopòsyon pwoteyin ki asosye ak mikrotubul LC3-II / I nan selil H9c2 [2]
Etid an vivo:pandan jounen an (9:00-15:00), jujubosides siyifikativman ogmante total dòmi ak mouvman rapid je (REM) dòmi, men pa te gen okenn efè enpòtan sou dòmi ki pa REM (NREM).Nan mitan lannwit (21:00-3:00), jujubosides siyifikativman ogmante total dòmi ak NREM dòmi, espesyalman modere dòmi, men pa te gen okenn efè enpòtan sou dòmi REM ak dòmi dousman vag (SWS) [3].Tretman entraventricular ak jjuboside a te siyifikativman soulaje pa yon nan Y-labirent, evite aktif ak Morris dlo labirent mezi β 1-42 pwovoke aprantisaj ak memwa andikap nan sourit.Entracerebroventricular piki nan Jujuboside A diminye ipokanp a β 1-42 nivo siyifikativman inibit aktivite yo nan acetylcholinesterase (AChE) ak non, ak diminye kontni an ogmante nan malondialdehyde (MDA) nan ipokanp ak cortical serebral nan sourit enjekte nan vantrikul lateral β 1-42. [4]。
Eksperyans selilè:apre 7 jou nan kilti in vitro, selil yo te kontinyèlman ekspoze pou 24 èdtan oswa 72 èdtan, epi yo pa te ekspoze a mwayen ki gen Jujuboside A oswa dyazepam oswa toude.Vektè te ajoute nan gwoup kontwòl la;Gwoup dyazepam te ajoute 10 μ M dyazepam;Jujuboside A82 μ M (apeprè 0.1g / L) ak 41 μ M (apeprè 0.05 g / L) te ajoute nan gwoup jua-h (gwo dòz Jujuboside A) ak jua-l (dòz ki ba Jujuboside A), respektivman.Yo te izole RNA total nan selil yo pou plis analiz [1].
Eksperyans bèt:sourit: yo te enjekte yon nan ICV β 1-42 pwovoke defisyans mantal nan sourit.Lè sa a, sourit yo te sou fòm piki ak Jujuboside A (0.02 ak 0.2 mg / kg) entraventricular (ICV) pou 5 jou.Y labirent, evite aktif ak tès labirent dlo Morris yo te fèt sou sourit [1].
Alyas angle nan Jujuboside A
α-L-arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3 )]-
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α -L-arabinopyranoside
jujuboside C
α-L-Arabinopyranoside, (3β,16β,23R)-16,23:16,30-diepoxy-20-hydroxydammar-24-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1- >2)-O-[O-β-D-glucopyranosyl-(1->6)-O-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3 )]-
JujubosideA
(3β,16β,23R)-20-Hydroxy-16,23:16,30-diepoxydammar-24-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D -glucopyranosyl-(1->6)-[β-D-xylopyranosyl-(1->2)]-β-D-glucopyranosyl-(1->3)]-α-L-arabinopyranoside
