Ngwaahịa

Nkọwa:monoammonium glycyrrhizinate hydrate nwere ihe omume ọgwụ dị ka mgbochi mkpali, mgbochi nfụkasị, mgbochi ọnya afọ na mgbochi ịba ọcha n'anya.

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Na Ọmụmụ Vivo:Mmụba nke ngụgụ w / D ịdị arọ belatara nke ukwuu site na nchịkwa nke nnukwu na ọkara doses nke mag (10 na 30 mg / kg).Pretreatment na mag (10 na 30 mg / kg) n'ụzọ dị irè belatara TNF- α Na IL-1 β Generation nke.Mag (10,30 mg / kg) belatara NF nke ukwuu ma e jiri ya tụnyere okwu protein LPS-κ Bp65.N'ụzọ dị iche, LPS belatara m nke ukwuu ma e jiri ya tụnyere ndị njikwa κ B-a Protein okwu, ebe mag (10 na 30 mg / kg) mụbara nke ukwuu I κ B- α Expression [1].E jiri ya tụnyere RIF na INH dị iche iche, ọgwụgwọ MAG dị ala na nke dị elu belatara nke ọma ast, alt, TBIL na TBA na 14 na 21 ụbọchị, na-egosi mmetụta nchebe nke MAG na RIF - na INH -.Mee mmerụ ahụ imeju.Otu ọgwụgwọ MAG mụbara ọkwa GSH imeju na ụbọchị 7, 14 na 21, ma belata ọkwa MDA nke ukwuu na ụbọchị 14 na 21 na RIF na INH na-agwọ oke, na-egosi mmetụta nchebe nke MAG na RIF - na.INH butere mmerụ ahụ imeju [2].

Nnwale anụmanụ:oke [1] n'ime ọmụmụ ihe a, eji BALB / c ụmụ oke (nwoke, 6-8 izu, 20-25g).E kewara oke oke na otu ise: otu njikwa, otu LPS na LPS + monoammonium glycyrrhizinate (Mag: 3,10 na 30mg / kg).Otu ọ bụla nwere oke 8.Ejiri ogwu ogwu intraperitoneal nke pentobarbital sodium (50 mg / n'arọ) were gbasie ụmụ oke ume.Ejiri mag (3, 10 na 30 mg / n'arọ) gbanye ụmụ oke tupu ha enwee mmerụ ahụ dị ukwuu.Mgbe elekere 1 gachara, a gbanyere LPS (5 mg / n'arọ) intracheal iji kpata mmerụ ahụ dị ukwuu.E nyere ụmụ oke nkịtị PBS [1].Oke [2] ji oke Wistar nwoke (180-220g).E kewara oke ndị ahụ na-enweghị usoro n'ime otu anọ: otu njikwa, RIF na INH otu, MAG obere dose otu na MAG dị elu, yana oke iri na ise n'ime otu ọ bụla.Enyere oke dị na RIF na otu INH RIF (60mg / kg) na INH (60mg / kg) site na ngwa ngwa otu ugboro n'ụbọchị;A na-eji MAG agwọ oke oke dị na MAG na dose nke 45 ma ọ bụ 90 mg / kg, yana RIF (60 mg / kg) na INH (60 mg / kg) ka enyere awa 3 mgbe nchịkwa MAG gasịrị;A na-eji saline nkịtị gwọọ oke ndị nọ n'òtù njikwa ahụ.Iji nyochaa mmetụta siri ike nke ọgwụ ahụ, egburu oke na otu ọ bụla 7, 14 na 21 ụbọchị mgbe nchịkwa gasịrị [2].

Ntụaka:1].Huang X, et al.Mmetụta Mgbochi Mgbochi nke Monoammonium Glycyrrhizinate na Ọrịa Lipopolysaccharide na-ebute nnukwu mmerụ ahụ nku ume na oke site na ịhazi ihe kpatara Nuclear-Kappa B Ụzọ nrịbama.Evid Based Complement Alternat Med.2015;2015:272474 .
[2].Zhou L, et al.Monoammonium glycyrrhizinate na-echebe rifampicin na hepatotoxicity nke isoniazid na-ebute site na ịhazi okwu nke onye na-ebugharị Mrp2, Ntcp, na Oatp1a4 na imeju.Pharm Biol.2016;54 (6): 931-7 .