Astragaloside IV CAS Nọmba 84687-43-4
Okwu mmalite
Utu aha Bekee:Astragaloside IV;beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R) -20,24-epoxy-16,25-dihydroxy-3- (beta-D-xylopyranosyloxy) -9,19-cyclolanostan-6-yl;(3beta,6alpha,9beta,16beta,20R,24S) -16,25-dihydroxy-3- (beta-D-xylopyranosyloxy) -20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-threo - hexopyranoside
Ụdị molekụla:C41H68O14
Aha kemịkalụ:17-[5- (1-Hydroxyl-1-methyl-ethyl)- 2methyl-tetrahydro- furan-2-yl] -4,4,13,14-tetramethyl-tetradecahydro-cyclopropa[9,10]cyclopenta[a] phenanthren-16-ol-3-β-D-aracopyranosyl-6-β-D- glucoside.
Mp:200-204 ℃
[α]D:-56.6 (c,0.13 na DMF)
UV:Oke 203 nm
ịdị ọcha:98%
Isi mmalite:legume Astragalus membranaceus, Astragalus pubescens.
Usoro nhazi usoro nke astragaloside IV
Njirimara physicochemical
[ọdịdị]:ọcha crystalline ntụ ntụ
[ịdị ọcha]:n'elu 98%, usoro nchọpụta: HPLC
[ihe ọkụkụ]:mgbọrọgwụ nke Astragalus Alexandrinus Boiss, Astragalus dissectus, Astragalus membranaceus (Fisch.) mgbọrọgwụ Bungede, Astragalus sieversianus Pall Root nke Astragalus spinosus Vahl, akụkụ ikuku nke Astragalus spinosus Vahl.
[ihe ngwaahịa]:Astragalus membranaceus wepụ bụ ntụ ntụ na-acha aja aja.
[Mkpebi ọdịnaya]:chọpụta site na HPLC (Ihe Okike VI D, Mpịakọta I, Chinese Pharmacopoeia, 2010 Edition).
A na-eji ọnọdụ Chromatographic na nyocha ngwa ngwa sistemụ} octadecyl silane bonded silica gel dị ka ihe ndochi, mmiri acetonitrile (32:68) ka a na-eji dị ka akụkụ mkpanaka, a na-eji ihe nchọpụta ọkụ na-ekpo ọkụ na-ekpo ọkụ na-achọpụta.Ọnụ ọgụgụ nke efere usoro ihe ọmụma agaghị abụ ihe na-erughị 4000 dịka ọnụ ọgụgụ kasị elu nke astragaloside IV si dị.
Nkwadebe nke ngwọta ntụaka, were ego kwesịrị ekwesị nke ntụaka astragaloside IV, tụọ ya nke ọma, ma tinye methanol iji dozie ngwọta nwere 0.5mg kwa 1ml.
Nkwadebe ngwọta nnwale:were ihe dị ka 4G ntụ ntụ site na ngwaahịa a, tụọ ya nke ọma, tinye ya na Soxhlet extractor, tinye 40ml nke methanol, gbanye ya n'abali, gbakwunye methanol kwesịrị ekwesị, okpomọkụ na reflux maka awa 4, nwetaghachi ihe mgbaze site na wepụ ma tinye uche. ọ ga-akọrọ, tinye 10ml mmiri ka igbari nke fọdụrụnụ, maa jijiji ma wepụ ya na saturated n-butanol ugboro 4, 40ml oge ọ bụla, jikọta n-butanol ngwọta, na-asa ya nke ọma na amonia test solution maka ugboro 2, 40ml nke ọ bụla. oge, tụfuo ihe ngwọta amonia, wepụ ihe ngwọta n-butanol, gbakwunye mmiri 5ml ka ọ gbazee ihe fọdụrụnụ, ma mee ka ọ dị jụụ, Site na D101 macroporous adsorption resin kọlụm (obosara dị n'ime: 37.5px, elu kọlụm: 300px), elute na 50ml mmiri. , tụfuo ihe ngwọta mmiri, elute na 30ml nke 40% ethanol, tụfuo eluent, elute na 80ml nke 70% ethanol, kpokọta eluent, kpochapu ya na nkụ, gbazee ihe fọdụrụ na methanol, bufee ya na flask volumetric 5ml, tinye ya. methanol na ọnụ ọgụgụ, maa jijiji nke ọma, nawee nweta ya.
Usoro mkpebi:banye n'ụzọ ziri ezi 10% nke ngwọta ntụaka n'otu n'otu μl, 20 μl.Nnwale ngwọta 20 ọ bụla μl.Tinye ya n'ime chromatograph mmiri mmiri, chọpụta ya, wee gbakọọ ya na nha nhata logarithm nke ụkpụrụ mpụga ụzọ isi ihe abụọ.
Gbakọọ dị ka ngwaahịa akọrọ, ọdịnaya nke astragaloside IV (c41h68o14) agaghị abụ ihe na-erughị 0.040%
Ihe omume ọgwụ
Akụkụ bụ isi dị irè nke Astragalus bụ polysaccharides na astragaloside.A na-ekewa Astragaloside n'ime astragaloside I, astragaloside II na astragaloside IV.N'ime ha, astragaloside IV, astragaloside IV, nwere ọrụ ndụ kacha mma.Astragaloside IV abụghị naanị mmetụta nke Astragalus polysaccharides, kamakwa ụfọdụ mmetụta na-enweghị atụ nke Astragalus polysaccharides.Ike ya dị ike karịrị okpukpu abụọ karịa nke astragalus polysaccharides, yana mmetụta mgbochi ya bụ ugboro 30 karịa nke Astragalus polysaccharides.N'ihi ọdịnaya dị ala na mmetụta dị mma, a na-akpọkwa ya "super astragalus polysaccharide".
1.Enhance mgbochi na ọrịa iguzogide.
Ọ nwere ike wepụ kpọmkwem ndị mba ọzọ na-awakpo ahụ, na-akwalite mgbochi, mgbochi na enweghị nke a kapịrị ọnụ, ma melite nguzogide ọrịa nke ahụ.Ọ nwere ike ịkwalite mmepụta nke antibody, ma mee ka ọnụ ọgụgụ nke antibody na-akpụ sel na uru ule hemolysis.Astragaloside IV nwere ike imeziwanye ọkwa mgbanwe nke lymphocyte na ọnụego nhazi E-rosette nke ọkụkọ gbachiri ọgwụ mgbochi ọrịa.Ọ bụ ihe dị irè activator nke monocyte macrophage usoro.Astragaloside IV nwekwara ike imeziwanye oxidation, GSH-Px na SOD na-eme n'ime akụkụ ahụ na-alụso ọrịa ọgụ, ma melite nchebe nchebe na ọrụ nlekota oru.
2.Antiviral mmetụta.
Ụkpụrụ mgbochi ya: na-akpali ọrụ nke macrophages na mkpụrụ ndụ T, na-amụba ọnụ ọgụgụ nke E-ring na-akpụ sel, na-akpali cytokines, na-akwalite mmepụta nke interleukin, na-eme ka anụ ahụ na-emepụta interferon endogenous, iji nweta nzube nke antiviral.Nsonaazụ gosiri na mkpokọta nchebe nke astragaloside IV na IBD bụ 98.33%, nke nwere ike igbochi ma gwọọ IBD nke ọma, ọ dịghịkwa ọdịiche dị ịrịba ama ma e jiri ya tụnyere ngwọta nkochi ime akwa dị elu.Astragaloside nwere ike ịkwalite ọrụ nke enzymes antioxidant n'ime ahụ, belata ọdịnaya nke LP0, belata mmebi nke ụdị ikuku oxygen na-emeghachi omume, wee si otú a belata ọnụọgụ na ọnwụ nke MD.Ọ nwere ike imeziwanye ọrụ nchebe dị ala nke ụbụrụ na-akpata, kwalite ọrụ nke mkpụrụ ndụ na-alụso ọrịa ọgụ, na-ahapụ ihe ndị na-akpata endogenous, ma gbochie igbu egbu na mgbochi nke mkpụrụ ndụ tumo nke peroxidation kpatara;Astragaloside a nwere ike igbochi uto nke nje influenza na ọrụ sialidase.Ọ nwere mmetụta dị ukwuu na ọrụ nke akpụkpọ ahụ nje virus influenza na mgbasa ozi na ntinye nke nje na sel nwere mmetụta.A na-ebelata ọnụ ọgụgụ ndị na-anwụ anwụ na akwa akwa nke anụ ọkụkọ, na ntinye akwa na akwa akwa akwa na mgbake dị mma karịa nke amantadine naanị otu njikwa, na mmetụta nke Astragalus polysaccharide abụghị ihe doro anya;Astragaloside IV nwere mmetụta igbu ọchụ na mgbochi mgbochi na nje.Ebumnuche bụ na iji astragaloside IV tupu achọpụta ọrịa na nje Nd, ya mere ọ kacha mma iji astragaloside IV ruo ogologo oge, Avian myeloblastic leukemia (AMB) 3 ụbọchị AA broilers nri astragaloside IV na ọrịa ahụ. nke nje AMB, nwere ike ibelata ọnụọgụ na ọnwụ nke AMB, mee ka ọdịnaya LPO dị na akụkụ ahụ ndị na-alụso ọrịa ọgụ dị ka splin na thymus, na-eme ka mmetụta splin na thymus na akụkụ ahụ ndị ọzọ na-alụso ọrịa ọgụ dị na mkpụrụ ndụ tumor myeloid.Nke abuo, astragaloside IV nwere ihe mgbochi doro anya na ọgwụgwọ ọgwụgwọ na ọrịa iku ume dị ka laryngotracheitis na-efe efe.Jiri.
3. Mmetụta nrụgide mgbochi.
Astragaloside IV nwere ike igbochi hyperplasia adrenal na thymus atrophy na oge ịdọ aka ná ntị nke nzaghachi nrụgide, ma gbochie mgbanwe ndị na-adịghị mma na oge nguzogide na oge ọdịda nke nzaghachi nrụgide, ka ọ wee rụọ ọrụ mgbochi nrụgide, karịsịa nwere ụkpụrụ abụọ dị ịrịba ama. mmetụta na enzymes na usoro nke nri metabolism, na-ebelata ma na-ewepụ mmetụta nke okpomọkụ nrụgide na physiological ọrụ nke ahụ ruo n'ókè ụfọdụ.
4. Dị ka onye na-akwalite uto.
Ọ nwere ike ịkwalite metabolism physiological nke mkpụrụ ndụ, kwalite mgbasa ọbara, kwalite metabolism nke ahụ anụmanụ, ma rụọ ọrụ nke nri na nlekọta ahụike.Nnyocha na-egosi na ọ nwere ike ịkwalite uto nke bifidobacteria na nje bacteria lactic acid ma nwee mmetụta nke probiotics.
5. Astragaloside IV nwere ike imeziwanye ọrụ cardiopulmonary.
Mee ka nkwekọrịta obi sie ike, chebe myocardium ma guzogide nkụda obi.Ọ nwekwara mmetụta nke ichebe imeju, mgbochi mkpali na analgesic.Enwere ike iji ya dị ka ọgwụgwọ adjuvant maka ọrịa nje na nje dị iche iche.
