Fraxin;Paviin;Fraxoside;Fraxetol- 8-glucoside CAS No.524-30-1
Ozi dị mkpa
Nọmba CAS:524-30-1 [1]
EINECS Mba:208-355-5
Ụdị molekụla:c16h18o10
Ibu Molecular:370.3081
Ọdịdị Molecular:(Foto nke 1)
Njirimara:Crystal acicular na-acha odo odo ma ọ bụ kristal flake.
Njupụta:1.634g/cm3
Ebe esi mmiri:722.2 Celsius C na 760 mmHg
Ebe mgbari:267 Celsius C
Nrụgide Steam:6.87e-22mmhg na 25 Celsius
Bioactivity nke Fraxin
Nkọwa:Enwere ike kewapụ Fraxin na Acer tegmentosum, F. ornus na a.hippocastanum.Ọ bụ glycoside nke fraxine [1] ma nwee antioxidant, mgbochi mkpali na mgbochi metastasis.Fraxin na-egosipụta ọrụ antioxidant site na igbochi cyclic adenylate phosphodiesterase [2].
Ebumnuche:cyclo AMP phosphodiesterase enzyme [2]
N'ime Vitro Ọmụmụ:Fraxin (100 μM) Ọ nweghị cytotoxicity na mkpụrụ ndụ Hep G2.Fraxin na mkpokọta cytotoxic nke na-abụghị nke cytotoxic belatara nke ukwuu mmepụta ROS nke t-BHP na-adabere na dose [1].Fraxin (0.5 mm) nwere ike ịbọ ọbọ free radicals na elu itinye uche ma nwee cytoprotective mmetụta na H2O2 mediated oxidative stress [2].
Ọmụmụ ihe na vivo:Fraxin (50 mg / n'arọ, PO) gbochiri CCl4 na-ebuli elu nke ALT na AST.Fraxin (10 na 50 mg / kg, PO) belatara ọkwa GSSG nke ukwuu (1.7 ± 0.3 na 1.5 ± 0.2 nm / g imeju, n'otu n'otu) ma e jiri ya tụnyere ọkwa GSSG na otu CCl4 a na-emeso ya.
Ntụaka:.Fraxin (50 mg/kg, po) na-egbochi mbuli elu CCl4 kpatara nke ALT na AST.Fraxin (10 na 50 mg / kg, po) na-ebelata ọkwa GSSG nke ukwuu (1.7 ± 0.3 na 1.5 ± 0.2 nM / g imeju, n'otu n'otu) ma e jiri ya tụnyere ọkwa GSSG nke otu CCl4-emeso[1].
[2].Whang WK, et al.Ogige eke, fraxin na kemịkalụ structurally metụtara fraxin na-echebe mkpụrụ ndụ pụọ na nrụgide oxidative.Exp Mol Med.2005 Ọkt 31;37 (5):436-46 .
